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Dynamically PEGylated and Borate ‐Coordination‐Polymer‐Coated Polydopamine Nanoparticles for Synergetic Tumor‐Targeted, Chemo‐Photothermal Combination Therapy
Abstract Multifunctional nanomaterials with efficient tumor‐targeting and high antitumor activity are highly anticipated in the field of cancer therapy. In this work, a synergetic tumor‐targeted, chemo‐photothermal combined therapeutic nanoplatform based on a dynamically PEGylated, borate‐coordination‐polymer‐coated polydopamine nanoparticle (PDA@CP‐PEG) is developed. PEGylation on the multifunctional nanoparticles is dynamically achieved via the reversible covalent interaction between the surface phenylboronic acid (PBA) group and a catechol‐containing poly(ethylene glycol) (PEG) molecule. Due to the acid...
Source: Small - February 12, 2018 Category: Nanotechnology Authors: Shucheng Liu, Jianming Pan, Jinxin Liu, Yue Ma, Fengxian Qiu, Lin Mei, Xiaowei Zeng, Guoqing Pan Tags: Full Paper Source Type: research

In vitro bactericidal and drug release properties of vancomycin-amino surface functionalized bioactive glass nanoparticles
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Vahid Zarghami, Mohammad Ghorbani, Kamran Pooshang Bagheri, Mohammad Ali ShokrgozarAbstractBioactive glass has been used clinically in bone repair applications for bone grafting because of its prominent physiochemical and osteogenic properties. Various attempts have been made to enhance bioactive glass efficiency in combination with other biomaterials such as antibiotics and growth factors. In present study, we developed a modification of bioactive glass nanoparticles that insured long term antibacterial effect. Bioactive glass n...
Source: Materials Chemistry and Physics - November 18, 2019 Category: Materials Science Source Type: research

Synergistic Effect of Reductase and Keratinase for Facile Synthesis of Protein Coated Gold Nanoparticles.
Abstract We have synthesized gold nanoparticles (GNPs) using chicken feather (poultry waste) and Bacillus subtilis RSE163. Disulphide reductase and keratinase produced by Bacillus subtilis during the degradation of chicken feather has been used to reduce Au(3+) form HAuCl4 precursor to produce gold nanoparticles. The synthesized biogenic GNPs were characterized by UV-Visible Spectroscopy, Transmission Electron Microscopy (TEM) and Zeta potential measurements. Fourier transform infrared (FTIR) spectroscopy indicates the presence of protein capping on as synthesized GNPs imparting multi-functionality to GNPs surface...
Source: Journal of Microbiology and Biotechnology - December 12, 2014 Category: Biotechnology Authors: Gupta S, Singh SP, Singh R Tags: J Microbiol Biotechnol Source Type: research

The Search for the Elusive Elixir of Life
By TOM EMERICK Here’s the executive summary: Most disease and health spending is age-related. As we age we get infirmities ranging from dementia to cancer to vascular disease. Nothing can prevent aging. Period. For millennia mankind has been been on a futile search to prevent aging. Search for the Elusive Elixir of Life For 3500 or more years mankind has been searching for the mythological Elixir of Life, the fountain of youth, the philosophers stone, pool of nectar, etc, that will defeat aging and extend life, if not achieve immortality. According to Wiki, “The elixir of life, also known as the elixir of immortality a...
Source: The Health Care Blog - February 4, 2016 Category: Consumer Health News Authors: Simon Nath Tags: THCB Tom Emerick Source Type: blogs

Internet search by the patients undergoing  hernia surgery about the disease and surgeon selection
ConclusionsLess than two-thirds of the hernia patients make Internet search about their disease. Higher education level, younger age, patient ’s preference for minimally invasive surgery and living in a city positively affect Internet search rates.
Source: Hernia - January 12, 2022 Category: Sports Medicine Source Type: research

Incidence of Online Health Information Search: A Useful Proxy for Public Health Risk Perception
Conclusions: Our study suggests a practical way to measure the public’s health risk perception for certain diseases using online information search volume by state. The social environment influences public risk perception regardless of disease incidence. Thus, monitoring the social variables can be very helpful in being ready to respond to the public’s behavior in dealing with public health threats.
Source: Journal of Medical Internet Research - June 17, 2013 Category: Journals (General) Authors: Bo LiangDebra L Scammon Source Type: research

Use of Internet Search Queries to Enhance Surveillance of Foodborne Illness.
Abstract As a supplement to or extension of methods used to determine trends in foodborne illness over time, we propose the use of Internet search metrics. We compared Internet query data for foodborne illness syndrome-related search terms from the most popular 5 Korean search engines using Health Insurance Review and Assessment Service inpatient stay data for 26 International Classification of Diseases, Tenth Revision, codes for foodborne illness in South Korea during 2010-2012. We used time-series analysis with Seasonal Autoregressive Integrated Moving Average (SARIMA) models. Internet search queries for "food p...
Source: Emerging Infectious Diseases - October 24, 2015 Category: Infectious Diseases Authors: Bahk GJ, Kim YS, Park MS Tags: Emerg Infect Dis Source Type: research

Linking Annual Prescription Volume of Antidepressants to Corresponding Web Search Query Data: A Possible Proxy for Medical Prescription Behavior?
Abstract: Persons using the Internet to retrieve medical information generate large amounts of health-related data, which are increasingly used in modern health sciences. We analyzed the relation between annual prescription volumes (APVs) of several antidepressants with marketing approval in Germany and corresponding web search query data generated in Google to test whether web search query volume may be a proxy for medical prescription practice. We obtained APVs of several antidepressants related to corresponding prescriptions at the expense of the statutory health insurance in Germany from 2004 to 2013. Web search query ...
Source: Journal of Clinical Psychopharmacology - November 3, 2015 Category: Psychiatry Tags: Original Contributions Source Type: research

Microscopic astronauts: BIOMEX and the search for life on Mars
This article originally appeared on ResearchGate News. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Science - The Huffington Post - June 21, 2016 Category: Science Source Type: news

Identification of Minimal Clinically Important Difference Scores of the Pediatric Quality of Life Inventory in Children, Adolescents, and Young Adults With Type 1 and Type 2 Diabetes.
CONCLUSIONSThese diabetes-specific reference points to interpret clinically meaningful change in PedsQL scores can be used in clinical care and research for youth with type 1 and type 2 diabetes. PMID: 23340884 [PubMed - as supplied by publisher]
Source: Diabetes Care - January 22, 2013 Category: Endocrinology Authors: Hilliard ME, Lawrence JM, Modi AC, Anderson A, Crume T, Dolan LM, Merchant AT, Yi-Frazier JP, Hood KK, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Why I Wouldn ’ t Take Google ’ s Depression Test
At the end of August, Google decided to make available directly on its site (through a “knowledge panel”) the ability to take a depression screening quiz. We know a thing or two about online depression screening quizzes, because I put one of the first interactive depression screening quizzes online back in 1996, long before Google even existed. Here’s the thing… Depression screening tests — like the PHQ-9 that Google is now offering on its website — are super helpful tools to give a person a little more insight into the possibility of having a serious mental illness. The problem with Goo...
Source: World of Psychology - September 1, 2017 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: Depression Disorders General Policy and Advocacy Technology depression quiz Depression Test Dr. Google google health search Source Type: blogs

Trends in the Prevalence of Ketoacidosis at Diabetes Diagnosis: The SEARCH for Diabetes in Youth Study
CONCLUSIONS: The frequency of DKA in youth with type 1 diabetes, although stable, remains high, indicating a persistent need for increased awareness of signs and symptoms of diabetes and better access to health care. In youth with type 2 diabetes, DKA at onset is less common and is decreasing over time.
Source: PEDIATRICS - April 1, 2014 Category: Pediatrics Authors: Dabelea, D., Rewers, A., Stafford, J. M., Standiford, D. A., Lawrence, J. M., Saydah, S., Imperatore, G., D'Agostino, R. B., Mayer-Davis, E. J., Pihoker, C., for the SEARCH for Diabetes in Youth Study Group Tags: Article Source Type: research

Administration Begins Search for New Contractors to Run Health Care Site
The Obama administration has begun a wide-ranging search for companies to run the online federal health insurance exchange to prevent a repeat of the site’s problems from last fall.
Source: NYT - April 29, 2014 Category: American Health Authors: By ROBERT PEAR Tags: Pfizer Inc PFE NYSE United States Politics and Government Patient Protection and Affordable Care Act (2010) CGI Group Inc GIB NYSE Health Insurance and Managed Care Accenture Ltd ACN NYSE Source Type: news

Prevalence of and Disparities in Barriers to Care Experienced by Youth with Type 1 Diabetes
Conclusions: This study indicates that a large proportion of youth with type 1 diabetes experience substantial barriers to care. Barriers to access and those associated with processes of quality care differed by sociodemographic characteristics. Future investigators should expand knowledge of the systemic processes that lead to disparate outcomes for some youth with diabetes and assess potential solutions.
Source: The Journal of Pediatrics - February 27, 2014 Category: Pediatrics Authors: Jessica M. Valenzuela, Michael Seid, Beth Waitzfelder, Andrea M. Anderson, Daniel P. Beavers, Dana M. Dabelea, Lawrence M. Dolan, Giuseppina Imperatore, Santica Marcovina, Kristi Reynolds, Joyce Yi-Frazier, Elizabeth J. Mayer-Davis, SEARCH for Diabetes in Tags: Original Articles Source Type: research