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Nanoparticles On My Mind
By KIM BELLARD
Nanoparticles are everywhere! By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare. But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger.
Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants. They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs
Signature of antiphase boundaries in iron oxide nanoparticles
Iron oxide nanoparticles find a wide variety of applications, including targeted drug delivery and hyperthermia in advanced cancer treatment methods. An important property of these particles is their maximum net magnetization, which has been repeatedly reported to be drastically lower than the bulk reference value. Previous studies have shown that planar lattice defects known as antiphase boundaries (APBs) have an important influence on the particle magnetization. The influence of APBs on the atomic spin structure of nanoparticles with the γ -Fe2O3 composition is examined via Monte Carlo simulations, explicitly considerin...
Source: Journal of Applied Crystallography - November 16, 2021 Category: Physics Authors: K ö hler, T. Feoktystov, A. Petracic, O. Nandakumaran, N. Cervellino, A. Br ü ckel, T. Tags: nanoparticles X-ray powder diffraction Monte Carlo simulations Debye scattering equation antiphase boundaries research papers Source Type: research
Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro
ang & Ya-ping Li
Source: Acta Pharmacologica Sinica - June 30, 2016 Category: Drugs & Pharmacology Authors: Hui-ping SunJing-han SuQing-shuo MengQi YinZhi-wen ZhangHai-jun YuPeng-cheng ZhangSi-ling WangYa-ping Li Tags: breast cancer 4T1 mammalian breast cancer cells metastasis nanoparticles silibinin photothermal therapy NIR laser irradiation Source Type: research
Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice
Xiao Yu Wu
Source: Acta Pharmacologica Sinica - June 1, 2017 Category: Drugs & Pharmacology Authors: Tian Zhang Preethy Prasad Ping Cai Chunsheng He Dan Shan Andrew Michael Rauth Xiao Yu Wu Tags: polymer-lipid hybrid nanoparticles triple negative breast cancer human MDA-MB-231 cells lung metastases doxorubicin mitomycin C synergistic action dual-targeted RGD Source Type: research
Woman diagnoses her own ovarian cancer with Google search
Sadie Rance turns to internet search engine for answers after being told stomach pains and constipation were due to Irritable Bowel Syndrome
Source: Telegraph Health - February 6, 2015 Category: Consumer Health News Tags: search ovarian Irritable Bowel Syndrome Sadie Rance diagnosed Cancer Google Source Type: news
Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland,
Brandee L. Branche,
Lauren E. Howard,
Robert J. Hamilton,
William J. Aronson,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
J Nanopart Res. 2023;25(3):43. doi: 10.1007/s11051-023-05690-w. Epub 2023 Feb 27.ABSTRACTRapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this ...
Source: Cell Research - March 6, 2023 Category: Cytology Authors: Reza Abbasi Ghazal Shineh Mohammadmahdi Mobaraki Sarah Doughty Lobat Tayebi Source Type: research
Sustained release of alpha ‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and contro...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 1, 2022 Category: Materials Science Authors: Toyin Aina,
Ali A. Salifu,
Sonu Kizhakkepura,
Yiporo Danyuo,
John D. Obayemi,
Josephine C. Oparah,
Theresa C. Ezenwafor,
Killian C. Onwudiwe,
Chukwuemeka J. Ani,
Suchi S. Biswas,
Chinyerem Onyekanne,
Olushola S. Odusanya,
Jonathan Madukwe,
Wi Tags: RESEARCH ARTICLE Source Type: research
Nanoparticles to Target Atherosclerotic Plaques
This popular science article takes a look at efforts to develop nanoparticles capable of reducing the size of plaques in blood vessels produced by the processes of atherosclerosis. These plaques narrow and deform blood vessels, ultimately breaking apart to cause blockages and ruptures of blood vessels that are often fatal. Atherosclerosis is caused at root by damaged lipids that enter the circulation and lodge in blood vessel tissue. This is followed by an unfortunate set of self-reinforcing signals sent by cells in the blood vessel wall and then by immune cells that turn up to try to deal with the problem. When immune cel...
Source: Fight Aging! - May 31, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Photoprotective activity of zirconia nanoparticles
Colloids Surf B Biointerfaces. 2021 Feb 18;202:111636. doi: 10.1016/j.colsurfb.2021.111636. Online ahead of print.ABSTRACTThe increasing incidence of diseases caused by the harmful effects of UV radiation in skin, predominantly skin cancer, induce the search for more efficient photoprotector agents. Nowadays, titanium dioxide (TiO2) and zinc oxide (ZnO) are the most widely used photoprotectors and therefore form the main components of commercially available sunscreens. Although the outstanding efficiency in absorbing and scattering UV radiation, mainly as nanoparticles, recent studies have raised concerns regarding the saf...
Source: Colloids and Surfaces - March 11, 2021 Category: Biotechnology Authors: Renata Guimar ães de Sá Tatiane Moraes Arantes Erenilda Ferreira de Macedo Lu ísa Molina Dona' Jeniffer C F Pereira Carolina Ramos Hurtado R Jose Varghese Oluwatobi Samuel Oluwafemi Dayane Batista Tada Source Type: research
Using Robots and Artificial Intelligence to Search for New Medicines
Courtesy of Dr. Adam Gormley.
Adam Gormley, Ph.D., describes himself as a creative and adventurous person—albeit, not creative in the traditional sense. “Science allows me to be creative; to me, it’s a form of art. I love being outdoors, going on sailing trips, and spending time adventuring with my family. Research is the same—it’s an adventure. My creative and adventurous sides have combined into a real love for science,” he says. Dr. Gormley currently channels his passion for science into his position as an assistant professor of biomedical engineering at Rutgers University in Piscataway, New Jersey.
Lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 24, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Medicines Profiles Source Type: blogs
Phytochemicals Formulated as Nanoparticles: Inventions,Recent Patents and Future Prospects.
CONCLUSION: If bioavailability constraint is overcome, diseases like cancer, alzheimer, diabetes, liver disorder etc. can be effectively targeted. By doing so, the largely affected society, will breathe the relief. The present article is an attempt to elaborate and conclude on how nanoparticles have been serving as a tool to enhance the effectiveness of phytochemicals, by solubilization, dissolution and consequent bioavailability enhancements, along with in vivo targeting. To further facilitate understanding, the review has been structured as disease/disorder and phytochemical wise with focus on their nanoparticles.
PM...
Source: Recent Patents on Drug Delivery and Formulation - November 24, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects.
Abstract
There are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attenti...
Source: Applied Microbiology and Biotechnology - January 10, 2014 Category: Microbiology Authors: Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M Tags: Appl Microbiol Biotechnol Source Type: research
Gold Nanoparticles: Promising Agent To Improve The Diagnosis And Therapy Of Cancer.
CONCLUSION: Gold nanoparticles have greatly improved the traditional treatment due to their unique properties. However, their size-dependent toxicity, distribution and clearance need further studies to make them a clinical reality.
PMID: 28952430 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - September 25, 2017 Category: Drugs & Pharmacology Authors: Ning L, Zhu B, Gao T Tags: Curr Drug Metab Source Type: research
