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Mitochondrial Toxicity of Cadmium Telluride Quantum Dot Nanoparticles in Mammalian Hepatocytes
There are an increasing number of studies indicating that mitochondria are relevant targets in nanomaterial-induced toxicity. However, the underlying mechanisms by which nanoparticles (NPs) interact with these organelles and affect their functions are unknown. The aim of this study was to investigate the effects of cadmium telluride quantum dot (CdTe-QD) NPs on mitochondria in human hepatocellular carcinoma HepG2 cells. CdTe-QD treatment resulted in the enlargement of mitochondria as examined with transmission electron microscopy and confocal microscopy. CdTe-QDs appeared to associate with the isolated mitochondria as dete...
Source: Toxicological Sciences - June 22, 2015 Category: Toxicology Authors: Nguyen, K. C., Rippstein, P., Tayabali, A. F., Willmore, W. G. Tags: Quantum Dot Nanoparticles and Mitochondrial Function Source Type: research

Evaluation of biological synthesized platinum nanoparticles using Ononidis radix extract on the cell lung carcinoma A549.
Abstract Due to the search for new methods for synthesizing nanomaterials, this work proposes the biological synthesis of platinum nanoparticles using Ononidis radix extract. The synthesized platinum nanoparticles were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The examination conducted by means of Transmission Electron Microscopy showed the presence of spherical and hexagonal platinum nanoparticles. Atomic Force Microscopy indicated the presence of locally ag...
Source: Biomedical Microdevices - July 24, 2019 Category: Biomedical Engineering Authors: Dobrucka R, Romaniuk-Drapała A, Kaczmarek M Tags: Biomed Microdevices Source Type: research

In vitro antioxidant, anticancer, anti-inflammatory, anti-diabetic and anti-Alzheimer potentials of innovative macroalgae bio-capped silver nanoparticles
Environ Sci Pollut Res Int. 2022 Apr 9. doi: 10.1007/s11356-022-20039-x. Online ahead of print.ABSTRACTThe antagonistic side effects of chemical medications led to the search for safe strategies such as biogenic agents. Correspondingly, this study aims to create biogenic, appropriate, auspicious and innovative therapeutic agents like Galaxaura elongata {GE}, Turbinaria ornata {TO} and Enteromorpha flexuosa {EF} macroalgae-based silver nanoparticles (Ag-NPs). The Ag+ reduction and the creation of Ag[GE]-NPs, Ag[TO]-NPs and Ag[EF]-NPs have been validated using UV-visible spectroscopy, Fourier transform infrared spectroscopy ...
Source: Environmental Science and Pollution Research International - April 9, 2022 Category: Environmental Health Authors: Manal N Abdel Azeem Osama M Ahmed Mohamed Shaban Khaled N M Elsayed Source Type: research

Competitive amperometric immunosensor for determination of p53 protein in urine with carbon nanotubes/gold nanoparticles screen-printed electrodes: A potential rapid and noninvasive screening tool for early diagnosis of urinary tract carcinoma.
Abstract Since p53 protein has become recognized biomarker for both diagnostic and therapeutic purposes in oncological diseases with particular relevance for bladder cancer, it is highly desirable to search for a novel sensing tool for detecting the patient's p53 level at the early stage. Here we report the first study on the development and validation of a novel disposable competitive amperometric immunosensor for determination of p53 protein at subnanomolar levels, based on p53 immobilization on gold nanoparticles/carbon nanotubes modified screen-printed carbon electrodes. The assay protocol requires the use of ...
Source: Analytica Chimica Acta - October 18, 2017 Category: Chemistry Authors: Giannetto M, Bianchi MV, Mattarozzi M, Careri M Tags: Anal Chim Acta Source Type: research

Novel design of NIR-triggered plasmonic nanodots capped mesoporous silica nanoparticles loaded with natural capsaicin to inhibition of metastasis of human papillary thyroid carcinoma B-CPAP cells in thyroid cancer chemo-photothermal therapy
Publication date: Available online 15 June 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Tianyu Yu, Lingling Tong, Yu Ao, Genmao Zhang, Yunpeng Liu, Hejia ZhangAbstractIn the search for developing a biomedicine based nanomaterial for therapeutic applications, here we described a new benign development of Photo-triggered Gold nanodots capped mesoporous silica nanoparticles Au@MSNs loaded with capsaicin (Cap) for photothermal therapy of cancer cells. Electron microscopic techniques (SEM and TEM) studies depict the anisotropic shape of Cap-Au@MSNs with mean size ≈110 nm. The successful amine ...
Source: Journal of Photochemistry and Photobiology B: Biology - June 15, 2019 Category: Speech-Language Pathology Source Type: research

Coffee-Derived Exosome-Like Nanoparticles: Are They the Secret Heroes?
CONCLUSION: For the first time in the literature, coffee edible plant-derived exosome-like nanoparticles were identified. These nanoparticles may have therapeutic effects on chronic liver diseases. Experimental studies, therefore, should be performed on disease models to demonstrate their efficacy.PMID:36262101 | DOI:10.5152/tjg.2022.21895
Source: The Turkish Journal of Gastroenterology - October 20, 2022 Category: Gastroenterology Authors: Murat Kantarc ıoğlu G ülşen Yıldırım P ınar Akpınar Oktar Serpil Yanbakan Zeynep B üşra Özer Deniz Yurtsever Sar ıca Serpil Ta şdelen Emel Bayrak Dilara Fatma Ak ın Balı Se çkin Öztürk Kamil Can Ak çalı Üstün Ezer Ahmet Emin K ürek Source Type: research