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Total 28367 results found since Jan 2013.

Antiproliferative activity of Camellia sinensis mediated silver nanoparticles on three different human cancer cell lines
Conclusion: The superior activity of the silver nanoparticles may be due to its spherical shape and smaller particle size 10–30 nm as confirmed from NTA and TEM analysis. The data obtained in the study reveal the potent therapeutic value of biogenic silver nanoparticles.
Source: Journal of Cancer Research and Therapeutics - November 28, 2018 Category: Cancer & Oncology Authors: Anu Yadav Vijay D Mendhulkar Source Type: research

Facile synthesis of Au/ZnO/Ag nanoparticles using Glechoma hederacea L. extract, and their activity against leukemia
Biomed Microdevices. 2021 Mar 8;23(1):14. doi: 10.1007/s10544-021-00557-0.ABSTRACTMetal combinations have been attracting the attention of scientists for some time. They usually exhibit new characteristics that are different from the ones possessed by their components. In this work, Au/ZnO/Ag nanoparticles were synthesized biologically using Glechoma hederacea L. extract. The synthesized Au/ZnO/Ag nanoparticles were characterized by UV-Vis, Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), and Atomic Force Microscopy (AFM). The microscopic methods co...
Source: Biomedical Microdevices - March 8, 2021 Category: Biomedical Engineering Authors: Renata Dobrucka Aleksandra Romaniuk-Drapa ła Mariusz Kaczmarek Source Type: research

Invivo and invitro evaluation of antitumor effects of iron oxide and folate core shell-iron oxide nanoparticles
This study was conducted to investigate the effect of magnetite nanoparticles (MNPs) and magnetite folate core shell (MFCS) on leukemic and hepatocarcinoma cell cultures as well as their effect on the animal model of acute myelocytic leukemia (AML). Through current study nanoparticles were synthesized, characterized by various techniques, and their properties were studied to confirm their nanostructure. Invivo study, nanoparticles were evaluated to inspect their cytotoxic activity against SNU-182 (human hepatocellular carcinoma), K562 (human leukemia), and THLE2 (human normal epithelial liver) cells via MTT test. Apoptotic...
Source: Braz J Biol - January 12, 2022 Category: Biology Authors: N N H Shosha S Elmasry M Moawad S H Ismail M Elsayed Source Type: research

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation
Conclusion It was showed that e-As4S4 could alleviate the metastatic features of aggressive breast cancers through correcting the tumor microenvironment, which prolonged the survival of tumor-bearing mice, showing its important therapeutic implications to the anti-metastasis therapy for breast cancer. Ethics Statement Six-week-old, female BALB/c mice were bred at the Experimental Animal Center at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (Beijing, China) under specific pathogen-free conditions. All the animal experiments reported herein were carried out in compliance with the regulatio...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

Chitosan-modified cobalt oxide nanoparticles stimulate TNF-α-mediated apoptosis in human leukemic cells.
The objective of this study was to develop chitosan-based delivery of cobalt oxide nanoparticles to human leukemic cells and investigate their specific induction of apoptosis. The physicochemical properties of the chitosan-coated cobalt oxide nanoparticles were characterized using transmission electron microscopy, dynamic light scattering, X-ray diffraction, and Fourier transform infrared spectroscopy. The solubility of chitosan-coated cobalt oxide nanoparticles was higher at acidic pH, which helps to release more cobalt ions into the medium. Chitosan-coated cobalt oxide nanoparticles showed good compatibility with normal ...
Source: Journal of Biological Inorganic Chemistry : JBIC - January 21, 2014 Category: Chemistry Authors: Chattopadhyay S, Dash SK, Kar Mahapatra S, Tripathy S, Ghosh T, Das B, Das D, Pramanik P, Roy S Tags: J Biol Inorg Chem Source Type: research

Butea monosperma bark extract mediated green synthesis of silver nanoparticles: characterization and biomedical applications
Publication date: Available online 11 December 2015 Source:Journal of Saudi Chemical Society Author(s): Sutanuka Pattanayak, Masud Rahaman Mollick, Dipanwita Maity, Sharmila Chakraborty, Sandeep Kumar Dash, Sourav Chattopadhyay, Somenath Roy, Dipankar Chattopadhyay, Mukut Chakraborty The work deals with an environmentally benign process for the synthesis of silver nanoparticle using Butea monosperma bark extract which is used both as a reducing as well as capping agent at room temperature. The reaction mixture turned brownish yellow after about 24 hrs. and an intense surface plasmon resonance (SPR) band at aroun...
Source: Journal of Saudi Chemical Society - December 12, 2015 Category: Chemistry Source Type: research

Assessing NLRP3 Inflammasome Activation by Nanoparticles.
Abstract NLRP3 inflammasome activation is one of the initial steps in an inflammatory cascade against pathogen/danger-associated molecular patterns (PAMPs/DAMPs), such as those arising from environmental toxins or nanoparticles, and is essential for innate immune response. NLRP3 inflammasome activation in cells can lead to the release of IL-1β cytokine via caspase-1, which is required for inflammatory-induced programmed cell death (pyroptosis). Nanoparticles are commonly used as vaccine adjuvants and drug delivery vehicles to improve the efficacy and reduce the toxicity of chemotherapeutic agents. Several studies...
Source: Mol Biol Cell - October 20, 2017 Category: Molecular Biology Authors: Sharma B, McLeland CB, Potter TM, Stern ST, Adiseshaiah PP Tags: Methods Mol Biol Source Type: research

Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia.
Abstract The main objective of this work was to assess the cytotoxic activity of Au/Pt/ZnO nanoparticles synthesized using Arctium lappa extract against leukemia. The Au/Pt/ZnO nanoparticles obtained as a result of biological synthesis were characterized by UV-Vis, Scanning (SEM) and Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Atomic Force Microscopy (AFM). The applied methods showed that the size of nanoparticles ranged from 10 to 40 nm. This work also assessed the cytotoxicity of Au/Pt/ZnO nanoparticles by means of MTT assay, and analyzed apoptosis as well as the ...
Source: Biomedical Microdevices - October 10, 2020 Category: Biomedical Engineering Authors: Dobrucka R, Romaniuk-Drapała A, Kaczmarek M Tags: Biomed Microdevices Source Type: research

Hydrothermal method-based synthesized tin oxide nanoparticles: Albumin binding and antiproliferative activity against K562 cells.
In conclusion, this data may indicate that SnO2 nanoparticles can be used as promising particles to be integrated into therapeutic platforms. PMID: 33321685 [PubMed - in process]
Source: Appl Human Sci - December 18, 2020 Category: Physiology Authors: Ahmadabad LE, Kalantari FS, Liu H, Hasan A, Gamasaee NA, Edis Z, Attar F, Ale-Ebrahim M, Rouhollah F, Babadaei MMN, Sharifi M, Shahpasand K, Akhtari K, Falahati M, Cai Y Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

Cerium Oxide Nanoparticles Modulate Cellular Health and Oxidative Stress in Breast Carcinoma Cells
Conclusions: Cerium oxide nanoparticles modulated apoptosis and reactive oxygen species in a dose dependent manner in breast carcinoma cells. Fig. 1. Reduced or absent Annexin V is demonstrated on the surface of MDA-MB231 cells treated with cerium oxide nanoparticles. Representative images of untreated cells (A) and Cisplatin treated cells (B) analyzed by confocal live imaging showed increased annexin V on the cell surfaces (bottom panel), while the cells treated with 25, 50, 100, and 200 μg/mL cerium oxide nanoparticles (C-F) showed reduced or absent Annexin V on the cell surface. Top panel shows representative images ...
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Bibb, E., Alajlan, N., Alsuwailem, S., George, R. Tags: Technologist Poster Session Source Type: research

Polyamidoamine Dendrimers Functionalized with ZnO-Chitosan Nanoparticles as an Efficient Surface for L-asparaginase Immobilization
In this study, the third-generation polyamidoamine dendrimer was functionalized with a 5-amino-1H-tetrazole heterocycle to load the synthesis enzyme and its surface groups. Then, chitosan was attached to the dendrimer by a suitable linker, and finally, zinc oxide nanoparticles were inserted into dendrimer cavities to increase loading. FTIR, FESEM, TEM, and DLS analysis showed that this new dendrimer has specific branches, and ZnO nanoparticles were spread between the branches and connected with the branches and chitosan biopolymer. Also proved the presence of stabilized L-asparaginase enzyme and ZnO nanoparticles in the de...
Source: Applied Biochemistry and Biotechnology - June 7, 2023 Category: Biochemistry Authors: Sudabeh Iraninasab Ahmad Homaei Elaheh Mosaddegh Masoud Torkzadeh-Mahani Source Type: research