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Zinc oxide nanoparticles induce toxicity in diffuse large B-cell lymphoma cell line U2932 via activating PINK1/Parkin-mediated mitophagy
Biomed Pharmacother. 2023 Jun 10;164:114988. doi: 10.1016/j.biopha.2023.114988. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Zinc oxide (ZnO) nanoparticles have excellent anti-tumor properties in the biomedical field. The present study aimed to explore the underlying mechanism by which ZnO nanoparticles induce toxicity in DLBCL cells (U2932) via the PINK1/Parkin-mediated mitophagy pathway. After U2932 cells were exposed to various concentrations of ZnO nanoparticles, the cell survival rate, reactive oxygen species (ROS) generation, cell cycle arrest, and changes i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2023 Category: Drugs & Pharmacology Authors: Zonghong Li Xuewei Yin Chunyi Lyu Teng Wang Wenhao Wang Jiachen Zhang Jinxin Wang Zhenzhen Wang Chen Han Ruixue Zhang Dadong Guo Ruirong Xu Source Type: research
Antitumor activity of galactoxyloglucan-gold nanoparticles against murine ascites and solid carcinoma.
Abstract
Galactoxyloglucan polysaccharide (PST001), isolated from the seed kernels of Tamarindus indica (Ti), was used both as reducing and capping agent for the preparation of gold nanoparticles (PST-Gold) of 20nm size. The present study evaluated the anticancer effects of the PST-Gold nanoparticles both in vitro and in vivo. The cytotoxicity was evaluated in the murine cancer cell lines, Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC). Galactoxyloglucan-gold nanoparticles (PST-Gold) not only retained the anticancer effects of PST001, but also showed enhanced cytotoxicity via induction of ap...
Source: Colloids and Surfaces - January 9, 2014 Category: Biotechnology Authors: Joseph MM, Aravind SR, George SK, Pillai KR, Mini S, Sreelekha TT Tags: Colloids Surf B Biointerfaces Source Type: research
Co-encapsulation of Doxorubicin with galactoxyloglucan nanoparticles for intracellular tumor-targeted delivery in murine ascites and solid tumors.
Abstract
Doxorubicin (Dox) treatment is limited by severe toxicity and frequent episodes of treatment failure. To minimize adverse events and improve drug delivery efficiently and specifically in cancer cells, encapsulation of Dox with naturally obtained galactoxyloglucan polysaccharide (PST001), isolated from Tamarindus indica was attempted. Thus formed PST-Dox nanoparticles induced apoptosis and exhibited significant cytotoxicity in murine ascites cell lines, Dalton's lymphoma ascites and Ehrlich's ascites carcinoma. The mechanism contributing to the augmented cytotoxicity of nanoconjugates at lower doses was va...
Source: Translational Oncology - October 1, 2014 Category: Cancer & Oncology Authors: Joseph MM, Aravind SR, George SK, Pillai RK, Mini S, Sreelekha TT Tags: Transl Oncol Source Type: research
Toxicity of silver nanoparticles towards tumoral human cell lines U-937 and HL-60
Publication date: 1 August 2017 Source:Colloids and Surfaces B: Biointerfaces, Volume 156 Author(s): Anna Barbasz, Magdalena Oćwieja, Maciej Roman The toxicity of three types of silver nanoparticles towards histiocytic lymphoma (U-937) and human promyelocytic cells (HL-60) was studied. The nanoparticles were synthesized in a chemical reduction method using sodium borohydride. Trisodium citrate and cysteamine hydrochloride were used to generate a negative and positive nanoparticle surface charge. The evaluation of cell viability, membrane integrity, antioxidant activity and the induction of inflammation were used to evalu...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2017 Category: Biochemistry Source Type: research
Bortezomib-loaded solid lipid nanoparticles: preparation, characterization, and intestinal permeability investigation.
Authors: Mahmoudian M, Valizadeh H, Zakeri-Milani P
Abstract
Bortezomib (BTZ), a proteasome inhibitor, is clinically used for the treatment of multiple myeloma and mantle cell lymphoma via intravenous or subcutaneous administration. Since BTZ has limited intestinal permeability, in this study, solid lipid nanoparticles (SLNs) were selected as lipid carrier to improve the intestinal permeability of BTZ. The nanoparticles were prepared by hot oil-in-water emulsification method and characterized for physicochemical properties. Moreover, in situ single-pass intestinal perfusion technique was used for intestinal permeab...
Source: Drug Development and Industrial Pharmacy - June 9, 2018 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity
Mater Sci Eng C Mater Biol Appl. 2021 Aug;127:112214. doi: 10.1016/j.msec.2021.112214. Epub 2021 May 29.ABSTRACTIn recent times, the development of functionalized nanoparticle methodology for biomedical applications has become a major challenge. In the present study, we prepared a novel gold nanoparticle (AuNP), named Curto-Cumin AuNP (CC-AuNP), using the biosynthetic process involving Nigella sativa (black cumin) seed extract and membrane vesicles isolated from the novel probiotic strain, Curtobacterium proimmune K3. Various spectrometric and microscopic analyses were performed to characterize the physicochemical properti...
Source: Appl Human Sci - July 6, 2021 Category: Physiology Authors: Sanjeevram Dhandapani Xingyue Xu Rongbo Wang Aditi Mitra Puja Hoon Kim Haribalan Perumalsamy Sri Renukadevi Balusamy Yeon-Ju Kim Source Type: research
Anticancer Effects of Gold Nanoparticles by Inducing Apoptosis in Bladder Cancer 5637 Cells
Biol Trace Elem Res. 2021 Aug 28. doi: 10.1007/s12011-021-02895-9. Online ahead of print.ABSTRACTNanotechnology is a developing and revolutionary science that has been widely recommended for diagnosis and treatment of cancer. Among the various nanoparticles used in nanotechnology, gold nanoparticles (AuNPs) have attracted much attentions due to their promising anticancer properties. Despite the potential advantages of AuNPs, their apoptotic and anti-angiogenic effects have not yet been reported on human bladder cancer 5637 cells. This motivated us to evaluate (reactive oxygen species) ROS-mediated apoptosis in 5637 cells. ...
Source: Biological Trace Element Research - August 29, 2021 Category: Biology Authors: Sajedeh Daei Nasrin Ziamajidi Roghayeh Abbasalipourkabir Korosh Khanaki Fatemeh Bahreini Source Type: research
Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells
Biomacromolecules. 2022 Apr 1. doi: 10.1021/acs.biomac.1c01497. Online ahead of print.ABSTRACTTo date, the application of RNA therapeutics to hematologic malignancies has been challenging owing to the resistance of blood cancer cells against conventional transfection methods. Herein, triple-targeting moiety-functionalized polymeric small interfering RNA (siRNA) nanoparticles were systematically developed for efficient targeted delivery of RNA therapeutics to hematologic cancer cells. Polymeric siRNAs were synthesized using rolling circle transcription and were surface-functionalized with three types of targeting moietiesâ”...
Source: Biomacromolecules - April 1, 2022 Category: Biochemistry Authors: Eunji Kwak Taehyung Kim Kyungjik Yang Young Min Kim Hwa Seung Han Kyung Hoon Park Ki Young Choi Young Hoon Roh Source Type: research
The Alleviative Efficacy of Vitamins A, C, and E Against Zinc Oxide Nanoparticles-Induced Hepatic Damage by Reducing Apoptosis in Rats
Biol Trace Elem Res. 2022 Apr 1. doi: 10.1007/s12011-022-03218-2. Online ahead of print.ABSTRACTNanoparticles are vastly exploited in today's technology. However, it is realized that exposure to high concentrations of nanoparticles (NPs) may have adverse effects on human health. According to previous reports, zinc oxide (ZnO) NPs cause toxic effects in tissues via inducing apoptosis. The current work was designed to evaluate possible protective activities of vitamins (Vits) A, C, and E against ZnO NPs-induced apoptosis in the liver of rats. To this aim, fifty-four adult male Wistar rats were randomly distributed into nine ...
Source: Cell Research - April 2, 2022 Category: Cytology Authors: Sajedeh Daei Roghayeh Abbasalipourkabir Maryam Khajvand-Abedini Nasrin Ziamajidi Source Type: research
Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells
Biomacromolecules. 2022 Apr 1. doi: 10.1021/acs.biomac.1c01497. Online ahead of print.ABSTRACTTo date, the application of RNA therapeutics to hematologic malignancies has been challenging owing to the resistance of blood cancer cells against conventional transfection methods. Herein, triple-targeting moiety-functionalized polymeric small interfering RNA (siRNA) nanoparticles were systematically developed for efficient targeted delivery of RNA therapeutics to hematologic cancer cells. Polymeric siRNAs were synthesized using rolling circle transcription and were surface-functionalized with three types of targeting moietiesâ”...
Source: Biomacromolecules - April 1, 2022 Category: Biochemistry Authors: Eunji Kwak Taehyung Kim Kyungjik Yang Young Min Kim Hwa Seung Han Kyung Hoon Park Ki Young Choi Young Hoon Roh Source Type: research
The Alleviative Efficacy of Vitamins A, C, and E Against Zinc Oxide Nanoparticles-Induced Hepatic Damage by Reducing Apoptosis in Rats
Biol Trace Elem Res. 2022 Apr 1. doi: 10.1007/s12011-022-03218-2. Online ahead of print.ABSTRACTNanoparticles are vastly exploited in today's technology. However, it is realized that exposure to high concentrations of nanoparticles (NPs) may have adverse effects on human health. According to previous reports, zinc oxide (ZnO) NPs cause toxic effects in tissues via inducing apoptosis. The current work was designed to evaluate possible protective activities of vitamins (Vits) A, C, and E against ZnO NPs-induced apoptosis in the liver of rats. To this aim, fifty-four adult male Wistar rats were randomly distributed into nine ...
Source: Biological Trace Element Research - April 2, 2022 Category: Biology Authors: Sajedeh Daei Roghayeh Abbasalipourkabir Maryam Khajvand-Abedini Nasrin Ziamajidi Source Type: research
Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells
Biomacromolecules. 2022 Apr 1. doi: 10.1021/acs.biomac.1c01497. Online ahead of print.ABSTRACTTo date, the application of RNA therapeutics to hematologic malignancies has been challenging owing to the resistance of blood cancer cells against conventional transfection methods. Herein, triple-targeting moiety-functionalized polymeric small interfering RNA (siRNA) nanoparticles were systematically developed for efficient targeted delivery of RNA therapeutics to hematologic cancer cells. Polymeric siRNAs were synthesized using rolling circle transcription and were surface-functionalized with three types of targeting moietiesâ”...
Source: Biomacromolecules - April 1, 2022 Category: Biochemistry Authors: Eunji Kwak Taehyung Kim Kyungjik Yang Young Min Kim Hwa Seung Han Kyung Hoon Park Ki Young Choi Young Hoon Roh Source Type: research
