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Nanoparticles On My Mind
By KIM BELLARD Nanoparticles are everywhere!  By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare.   But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger. Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants.  They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs

Phytofabrication of Selenium Nanoparticles From Emblica officinalis Fruit Extract and Exploring Its Biopotential Applications: Antioxidant, Antimicrobial, and Biocompatibility
Conclusion The present study shows phytofabrication of SeNPs from aqueous fruit extract of E. officinalis by facile, green, economic, and eco-friendly approach. The aqueous fruit extract of E. officinalis was rich with phenolics, flavonoids, and tannins, and was found appropriate for biosynthesis of nanoparticles. The synthesized PF-SeNPs exhibited highly stable, negative charge, amorphous nature, spherical shape and nano-size. The PF-SeNPs has presented efficient bio-potential applications, i.e., antioxidant, antimicrobial, and biocompatibility. The PF-SeNPs has shown potent free radical scavenging activity and it was fo...
Source: Frontiers in Microbiology - April 29, 2019 Category: Microbiology Source Type: research

Impact of nanoparticles on amyloid beta-induced Alzheimer's disease, tuberculosis, leprosy and cancer: A systematic review
Biosci Rep. 2023 Jan 11:BSR20220324. doi: 10.1042/BSR20220324. Online ahead of print.ABSTRACTNanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size of nanoparticles lies between 1-100 nm. Due to their small size and large surface area-to-volume ratio, nanoparticles exhibit high reactivity, greater stability and adsorption capacity. These important physicochemical properties attract scientific community to utilize them in biomedical field. Various types of nanoparticles (inorganic and organic) have broad applications in medical f...
Source: Bioscience Reports - January 11, 2023 Category: Biomedical Science Authors: Ayon Chakraborty Saswati Soumya Mohapatra Subhashree Barik Ipsita Roy Bhavika Gupta Ashis Biswas Source Type: research

Nanoparticle Biodistribution Coefficients: A Quantitative Approach for Understanding the Tissue Distribution of Nanoparticles
The objective of this manuscript is to provide quantitative insights into the tissue distribution of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 different tissues of mice were collected from literature. A total of 2018 datasets were analyzed and biodistribution of graphene oxide, lipid, polymeric, silica, iron oxide and gold nanoparticles in different tissues was quantitatively characterized using Nanoparticle Biodistribution Coefficients (NBC). It was observed that typically after intravenous administration most of the nanoparticles are accumulated in the liver (NBC=17.56 %ID/g) and ...
Source: Advanced Drug Delivery Reviews - January 22, 2023 Category: Drugs & Pharmacology Authors: Mokshada Kumar Priyanka Kulkarni Shufang Liu Nagendra Chemuturi Dhaval K Shah Source Type: research

Nanoparticles used to treat damaged arteries
Conclusion This exciting study in mice has shown that nanoparticles can be manufactured to target the plaques that form in atherosclerosis, and help stabilise them. It appears that the nanoparticles honed in on the plaques, rather than affecting other organs such as the spleen or liver, which gives an early indication that there may not be substantial side effects. However, it will be necessary to see if the same holds true for other organs. As with all mice studies, they give an indication of the likely biological effects of a new technique, but they do not provide the full picture of what may happen in humans, especially...
Source: NHS News Feed - February 19, 2015 Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Source Type: news

Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
Conclusions: In the present study, we used three different optical techniques to show that within a 24-hour period PBCA nanoparticles degraded significantly inside cells, releasing their payload into the cytosol, while POCA nanoparticles remained intact. This indicates that it is possible to tune the intracellular drug release rate by choosing appropriate monomers from the PACA family or by using hybrid PACA nanoparticles containing different monomers. In addition, we showed that the uptake of PACA nanoparticles depends not only on the monomer material, but also on the cell type, and that different cell lines can use diffe...
Source: Journal of Nanobiotechnology - January 8, 2016 Category: Nanotechnology Authors: Einar SulheimHabib BaghirovEva von HaartmanAndreas BøeAndreas ÅslundYrr MørchCatharina de Lange Davies Source Type: research

Chemical Engineers Help Nanoparticles Better Target Brain Tumors
Nanoparticles (in red) being taken up in the brain of a live rat model with glioblastoma (in green). Getting drugs into the brain by cloaking them within nanoparticles that can sneak through the blood-brain barrier has been the focus of a lot of nano...
Source: Medgadget - May 23, 2017 Category: Medical Devices Authors: Editors Tags: Nanomedicine Oncology Source Type: blogs

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation
Conclusion It was showed that e-As4S4 could alleviate the metastatic features of aggressive breast cancers through correcting the tumor microenvironment, which prolonged the survival of tumor-bearing mice, showing its important therapeutic implications to the anti-metastasis therapy for breast cancer. Ethics Statement Six-week-old, female BALB/c mice were bred at the Experimental Animal Center at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (Beijing, China) under specific pathogen-free conditions. All the animal experiments reported herein were carried out in compliance with the regulatio...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: Potential for targeting experimental brain tumors
This study demonstrates the use of magnetic resonance image-guided transcranial focused ultrasound to open the BBB and enable spectral mapping of nanoparticles with surface enhanced Raman scattering (SERS)-based molecular imaging for experimental tumor tracking.Graphical Abstract: Surface enhanced Raman scattering (SERS) nanoparticles have gained prominence in their potential diagnostic and therapeutic applications in cancer medicine. Focused ultrasound is a novel technique that can enhance the delivery of nanoparticles across the blood-brain barrier. In this study we demonstrate the feasibility of delivering SERS gold nan...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - December 30, 2013 Category: Nanotechnology Authors: Roberto Jose Diaz, Patrick Z. McVeigh, Meaghan A. O’Reilly, Kelly Burrell, Matthew Bebenek, Christian Smith, Arnold B. Etame, Gelareh Zadeh, Kullervo Hynynen, Brian C. Wilson, James T. Rutka Tags: Central Nervous System, Brain Neoplasms, Glioma, MRI-Guided Ultrasound, Crossing BBB, SERS-Tagged Au NPs Source Type: research

Abstract 4459: Characterization of a novel magnetic nanoparticles formulation for cancer therapeutic applications
We have successfully engineered a magnetic nanoparticles (MAG-NPs) formulation using a multi-layer approach which can be used for drug/gene/biomolecule delivery, hyperthermia, and magnetic resonance imaging (MRI) applications in cancer therapeutics. Overcoming nanoparticles clearance by the immune system remains a major challenge. This formulation is designed to provide an additional surface layer as molecular “authentication” that the body does not recognize as foreign material. The interaction between the surface of nanoparticles and plasma proteins leads to nanoparticle-protein complex which determines the rational ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yallapu, M. M., Chauhan, N., Othman, S. F., Khalilzad-Sharghi, V., Jaggi, M., Chauhan, S. C. Tags: Cancer Chemistry Source Type: research

Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells.
Abstract A major limitation in the treatment of glioblastoma (GBM), the most common and deadly primary brain cancer, is delivery of therapeutics to invading tumor cells outside of the area that is safe for surgical removal. A promising way to target invading GBM cells is via drug-loaded nanoparticles that bind to fibroblast growth factor-inducible 14 (Fn14), thereby potentially improving efficacy and reducing toxicity. However, achieving broad particle distribution and nanoparticle targeting within the brain remains a significant challenge due to the adhesive extracellular matrix (ECM) and clearance mechanisms in ...
Source: Biomaterials - January 3, 2015 Category: Materials Science Authors: Schneider CS, Perez JG, Cheng E, Zhang C, Mastorakos P, Hanes J, Winkles JA, Woodworth GF, Kim AJ Tags: Biomaterials Source Type: research

Sensitive imaging of magnetic nanoparticles for cancer detection by active feedback MR.
CONCLUSION: The spin dynamics originated from selective self-excitation and fixed-point dynamics under active feedback fields have been shown to be sensitive to dipolar fields generated by magnetic nanoparticles. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc. PMID: 25845581 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - April 4, 2015 Category: Radiology Authors: Li Z, Hsu CH, Dimitrov N, Hwang DW, Chang HW, Hwang LP, Lin YY Tags: Magn Reson Med Source Type: research

Abstract B46: Development of biodegradable Fn14-targeted nanoparticles for controlled drug delivery for invasive brain tumors
Conclusion: We have developed a nanoparticle platform that can diffuse and penetrate within brain tissue and selectively target remote experimental GBM tumors. Using this approach we can optimize therapeutics versions to improve drug efficacy while limiting many of the side effects and risks of free drug and non-targeted therapies.Citation Format: Jimena G. Perez, Craig S. Schneider, Nina Connolly, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim. Development of biodegradable Fn14-targeted nanoparticles for controlled drug delivery for invasive brain tumors. [abstract]. In: Proceedings of the AACR Special Conference...
Source: Cancer Research - December 9, 2015 Category: Cancer & Oncology Authors: Perez, J. G., Schneider, C. S., Connolly, N., Winkles, J. A., Woodworth, G. F., Kim, A. J. Tags: Other Topics Source Type: research