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Size and Shape Directed Novel Green Synthesis of Plasmonic Nanoparticles Using Bacterial Metabolites and Their Anticancer Effects
Front Microbiol. 2022 Apr 11;13:866849. doi: 10.3389/fmicb.2022.866849. eCollection 2022.ABSTRACTThe growing need for developing new synthesis methods of plasmonic nanoparticles (PNPs) stems from their various applications in nanotechnology. As a result, a variety of protocols have been developed for the synthesis of PNPs of different shapes, sizes, and compositions. Though widely practiced, the chemical synthesis of PNPs demands stringent control over the experimental conditions, often employs environmentally hazardous chemicals for surface stabilization, and is frequently energy-intensive. Additionally, chemically obtain...
Source: Cancer Control - May 2, 2022 Category: Cancer & Oncology Authors: Snehal Patil Murali Sastry Atul Bharde Source Type: research
Electrochemical molecularly bioimprinted siloxane biosensor on the basis of core/shell silver nanoparticles/EGFR exon 21 L858R point mutant gene/siloxane film for ultra-sensing of Gemcitabine as a lung cancer chemotherapy medication
Publication date: Available online 9 September 2019Source: Biosensors and BioelectronicsAuthor(s): Yalda Shoja, Ahmad Kermanpur, Fathallah Karimzadeh, Javad Ghodsi, Amir Abbas Rafati, Siavash AdhamiAbstractIn search for improvements in bioanalysis electrochemical sensors, for better assessment of anti-cancer drugs, it is necessary for their detection limits to be minimized and the sensitivity and selectivity to be surpassed simultaneously; whereas, resolving any probable interfering with other medical treatments are considered. In this work, a novel approach was adopted for detection and assessment of Gemcitabine (GEM) as ...
Source: Biosensors and Bioelectronics - September 10, 2019 Category: Biotechnology Source Type: research
Involvement of ABC transporters in the detoxification of non-substrate nanoparticles in lung and cervical cancer cells
Toxicology. 2021 Mar 22:152762. doi: 10.1016/j.tox.2021.152762. Online ahead of print.ABSTRACTThis paper aimed to systemically investigate the role of adenosine triphosphate-binding cassette (ABC transporters) in the detoxification of non-substrate nanoparticles including titanium dioxide (n-TiO2, 5-10 nm) and gold (AuNPs, 3 nm, 15 nm, and 80 nm, named as Au-3, Au-15 and Au-80) in human lung cancer (A549) and human cervical cancer (HeLa) cells. All these nanoparticles were of larger hydrophilic diameters than the channel sizes of ABC transporters, thus should not be the substrates of membrane proteins. After 24-h treatment...
Source: Toxicology - March 26, 2021 Category: Toxicology Authors: Tongkuo Yuan Jiaojiao Sun Jingjing Tian Jia Hu Huancai Yin Jian Yin Source Type: research
Development of paclitaxel loaded pegylated gelatin targeted nanoparticles for improved treatment efficacy in non-small cell lung cancer (NSCLC): an in vitro and in vivo evaluation study
CONCLUSION: This study confirms the potential use of paclitaxel loaded PEGylated gelatin targeted nanoparticles for improved efficacy in non-small cell lung cancer (NSCLC) treatment.PMID:34355554 | DOI:10.18388/abp.2020_5431
Source: Acta Biochim Pol - August 6, 2021 Category: Biochemistry Authors: Minwei Gu Jun Luan Kun Song Cao Qiu XiaoLi Zhang Mingyong Zhang Source Type: research
Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth
Biomaterials. 2022 Apr 23;285:121539. doi: 10.1016/j.biomaterials.2022.121539. Online ahead of print.ABSTRACTLung cancer is a major contributor to cancer-related death worldwide. siRNA nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to overcome to increase siRNA delivery to solid tumors, including penetration of nanoparticles into a complex microenvironment following systemic delivery while avoiding rapid clearance by the reticuloendothelial system, and limited siRNA release from endosomes once inside the cell. Here we characterized cell uptake, intracellular trafficking, and gene si...
Source: Biomaterials - May 2, 2022 Category: Materials Science Authors: Z Ma S W Wong H Forgham L Esser M Lai M N Leiske K Kempe G Sharbeen J Youkhana F Mansfeld J F Quinn P A Phillips T P Davis M Kavallaris J A McCarroll Source Type: research
Chitosan-alginate nanoparticles of cabazitaxel: Design, dual-receptor targeting and efficacy in lung cancer model
Int J Biol Macromol. 2022 Sep 8:S0141-8130(22)01976-6. doi: 10.1016/j.ijbiomac.2022.09.053. Online ahead of print.ABSTRACTCabazitaxel (CZT) loaded chitosan-alginate based (CSA) nanoparticles were developed with dual targeting functions of both folate receptor and epidermal growth factor receptor (EGFR) using ionic gelation technique. The chitosan-folate conjugate was synthesized, and characterized by using FTIR, NMR and Mass spectroscopy. The physicochemical parameters and morphology of all CSA nanoparticles were examined. The degree of conjugation of folic acid and cetuximab (CTXmab) was determined by UV-Visible spectrosc...
Source: International Journal of Biological Macromolecules - September 11, 2022 Category: Biochemistry Authors: None Vikas Abhishesh Kumar Mehata M Nikitha Lakshmi Suseela Chittaranjan Behera Pooja Kumari Sanjeev Kumar Mahto Madaswamy S Muthu Source Type: research
Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells
CONCLUSIONS: Our study revealed that the simultaneous use of ART and MET in the optimized PEGylated niosomal nanoparticles delivery system could be an appropriate approach to improve the effectiveness of lung cancer treatment.PMID:36859742 | DOI:10.1007/s43440-023-00462-8
Source: Pharmacological Reports - March 2, 2023 Category: Drugs & Pharmacology Authors: Rasoul Shahbazi Davoud Jafari-Gharabaghlou Zohreh Mirjafary Hamid Saeidian Nosratollah Zarghami Source Type: research
