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Sustained release of alpha ‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and contro...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 1, 2022 Category: Materials Science Authors: Toyin Aina,
Ali A. Salifu,
Sonu Kizhakkepura,
Yiporo Danyuo,
John D. Obayemi,
Josephine C. Oparah,
Theresa C. Ezenwafor,
Killian C. Onwudiwe,
Chukwuemeka J. Ani,
Suchi S. Biswas,
Chinyerem Onyekanne,
Olushola S. Odusanya,
Jonathan Madukwe,
Wi Tags: RESEARCH ARTICLE Source Type: research
Sialic Acid-Targeted Cyclodextrin-Based Nanoparticles Deliver CSF-1R siRNA and Reprogram Tumour-Associated Macrophages for Immunotherapy of Prostate Cancer
Eur J Pharm Sci. 2023 Mar 20:106427. doi: 10.1016/j.ejps.2023.106427. Online ahead of print.ABSTRACTProstate cancer remains a serious condition threatening the health of men. Due to the complicated nature of the tumour microenvironment (TME), conventional treatments face challenges including poor prognosis and tumour resistance, therefore new therapeutic strategies are urgently needed. Small interfering RNA (siRNA), a double-stranded non-coding RNA, regulates specific gene expression through RNA interference. Tumour-associated macrophages (TAMs) are a potential therapeutic target in cancer immunotherapy. Colony stimulating...
Source: European Journal of Pharmaceutical Sciences - March 22, 2023 Category: Drugs & Pharmacology Authors: Yao Sun Michael F Cronin Monique C P Mendon ça Jianfeng Guo Caitriona M O'Driscoll Source Type: research
Sialic acid-targeted cyclodextrin-based nanoparticles deliver CSF-1R siRNA and reprogram tumour-associated macrophages for immunotherapy of prostate cancer
Eur J Pharm Sci. 2023 Mar 21;185:106427. doi: 10.1016/j.ejps.2023.106427. Online ahead of print.ABSTRACTProstate cancer remains a serious condition threatening the health of men. Due to the complicated nature of the tumour microenvironment (TME), conventional treatments face challenges including poor prognosis and tumour resistance, therefore new therapeutic strategies are urgently needed. Small interfering RNA (siRNA), a double-stranded non-coding RNA, regulates specific gene expression through RNA interference. Tumour-associated macrophages (TAMs) are a potential therapeutic target in cancer immunotherapy. Colony stimula...
Source: European Journal of Pharmaceutical Sciences - March 22, 2023 Category: Drugs & Pharmacology Authors: Yao Sun Michael F Cronin Monique C P Mendon ça Jianfeng Guo Caitriona M O'Driscoll Source Type: research
Sustainable Nanoparticles from Stephania glabra and Analysis of Their Anticancer Potential on 2D and 3D Models of Prostate Cancer
Appl Biochem Biotechnol. 2023 Sep 8. doi: 10.1007/s12010-023-04700-w. Online ahead of print.ABSTRACTIn pursuit of a novel effective treatment for prostate cancer, methanolic extract of Stephania glabra tubers (Sg-ME) was utilized to fabricate silver (Sg-AgNP), copper oxide (Sg-CuONP), and silver-copper bimetallic nanoparticles (Sg-BNP). The characterization of the nanoparticles confirmed spherical shape with average diameters of 30.72, 32.19, and 25.59 nm of Sg-AgNP, Sg-CuONP, and Sg-BNP, respectively. Interestingly, these nanoparticles exhibited significant cytotoxicity toward the prostate cancer (PC3) cell line while bei...
Source: Applied Biochemistry and Biotechnology - September 8, 2023 Category: Biochemistry Authors: Prachi Vaid Adesh K Saini Raju Kumar Gupta Eshu Singhal Sinha Deepak Sharma Walaa F Alsanie Vijay Kumar Thakur Reena V Saini Source Type: research
Super Para-Magnetic Iron Oxide Nanoparticles (SPIONs) in the Treatment of Cancer: Challenges, Approaches and its Pivotal Role in Pancreatic, Colon and Prostate Cancer
Curr Drug Deliv. 2022 May 9. doi: 10.2174/1567201819666220509164611. Online ahead of print.ABSTRACTSuper Para- magnetic Iron Oxide Nanoparticles (SPIONs) have been manifested for their broad spectrum of applications ranging from biomedical imaging to the treatment of many diseases. Many experiments are being conducted across the globe to especially investigate their potential in the field of targeted treatment for malignant tissues. However, challenges pertaining to the desired delivery of anticancer drugs in the body remain unresolved or unattended. The bare iron oxide nanoparticles are liable to form agglomerates or get ...
Source: Current Drug Delivery - May 17, 2022 Category: Drugs & Pharmacology Authors: Sameea Ahmed Khan Rajesh Sharma Source Type: research
Functionalized nanoparticles targeting biomarkers for prostate cancer imaging and therapy
Am J Clin Exp Urol. 2022 Jun 15;10(3):142-153. eCollection 2022.ABSTRACTNanomedicine is an evolving field of scientific research with unique advantages and challenges for the detection and treatment of medical diseases. Since 1995, the FDA has approved the administration of nanoparticle-based therapies. The initial generation of nanoparticles relied on an enhanced permeability and retention effect, associated with an increased penetrability of tumor related blood vessels. With increasing knowledge of biomarkers and molecular targets, active targeting of circulating tumor cells by nanoparticles provides an exciting area for...
Source: Clinical Prostate Cancer - July 25, 2022 Category: Cancer & Oncology Authors: Ankur U Choksi Amir I Khan Soum D Lokeshwar Daniel Segal Robert M Weiss Darryl T Martin Source Type: research
Sustained release of alpha-methylacyl-CoA racemase (AMACR) antibody-conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and contro...
Source: Biomed Res - October 31, 2022 Category: Research Authors: Toyin Aina Ali A Salifu Sonu Kizhakkepura Yiporo Danyuo John D Obayemi Josephine C Oparah Theresa C Ezenwafor Killian C Onwudiwe Chukwuemeka J Ani Suchi S Biswas Chinyerem Onyekanne Olushola S Odusanya Jonathan Madukwe Winston O Soboyejo Source Type: research
