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Rare-earth nanoparticles induce depression, anxiety-like behavior, and memory impairment in mice
Food Chem Toxicol. 2021 Jul 28:112442. doi: 10.1016/j.fct.2021.112442. Online ahead of print.ABSTRACTRare-earth nanoparticles have been widely studied for disease diagnosis, in vivo optical imaging, biosensing, and drug delivery. However, the effects of rare-earth nanoparticles on a central nervous system remain unclear. Here, we report that the continuous exposure to rare-earth nanoparticles in mice can cause behavioral alterations including cognitive deficits, anxiety, and depression-like behavior. Using an open-field test and a morris water maze, we showed that long-term exposure to rare-earth nanoparticles may lead to ...
Source: Food and Chemical Toxicology - July 31, 2021 Category: Food Science Authors: Caihou Lin Guifen Liu Yulong Huang Shunyi Liu Binghua Tang Source Type: research

Targeted Nursing Combined with Endoscopic Submucosal Injection of Carbon Nanoparticles in the Treatment of Colorectal Cancer
CONCLUSION: Targeted nursing alleviates the negative emotions of patients with colorectal cancer and improves their compliance, nursing satisfaction, daily living ability, and quality of life.PMID:35685723 | PMC:PMC9173991 | DOI:10.1155/2022/8663645
Source: Cancer Control - June 10, 2022 Category: Cancer & Oncology Authors: Libo Yin Source Type: research

Green synthesized Ag-nanoparticles using Scutellaria multicaulis stem extract and their selective cytotoxicity against breast cancer
Anal Biochem. 2022 Jun 14:114786. doi: 10.1016/j.ab.2022.114786. Online ahead of print.ABSTRACTScutellaria multicaulis is a medicinal herb which has been extensively prescribed in Iranian traditional medicine for treatment of infections, constipation, wounds, and also as medication for anxiety. To evaluate biological activities of biosynthesized silver nanoparticles, silver nanoparticles (Sm-AgNPs) were synthesized using S. multicaulis extract as capping and reducing agent. Characterization studies using UV-vis, XRD, DLS, Zeta potential, FESEM, EDX, TEM, FTIR, RAMAN and TGA assays indicated that Sm-AgNPs had optimal shape,...
Source: Analytical Biochemistry - June 17, 2022 Category: Biochemistry Authors: Zahra Gharari Parichehr Hanachi Tony R Walker Source Type: research

The relationship between emotion regulation strategies and job search behavior among fourth-year university students
This study investigated the effect of emotion regulation strategies on job search behavior in combination with anxiety and job search self-efficacy among Chinese university fourth-year students (N = 816, mean age = 21.98, 31.5% male, 34.9% majored in science, 18.0% from “211 Project” universities). Results showed that cognitive reappraisal was positively related to job search behavior, while expressive suppression was negatively related to job search behavior. Additionally, anxiety was negatively related to job search behavior, while job search self-efficacy was positively associated with job search behavior. Moreo...
Source: Journal of Adolescence - June 24, 2017 Category: Child Development Source Type: research

Neurobehavioral and biochemical modulation following administration of MgO and ZnO nanoparticles in the presence and absence of acute stress
Publication date: 15 June 2018 Source:Life Sciences, Volume 203 Author(s): Mozhgan Torabi, Mahnaz Kesmati, Nahid Pourreza, Hossein Najafzadeh Varzi, Hamid Galehdari In this work, the effects of MgO and ZnO nanoparticles were investigated on some behavioral, hormonal and biochemical changes following acute stress. Wistar male rats were divided into groups of control, different times of restraint stress (90, 180 and 360 min), nano-MgO or nano-ZnO alone and with acute restraint stress. Anxiety-like behaviors and pain perception were evaluated by elevated plus maze and hot plate apparatus respectively. Levels of corticoster...
Source: Life Sciences - May 18, 2018 Category: Biology Source Type: research

Pandemic Job Search Anxiety is Common; How You Channel It May Make the Difference
COVID-19-related anxiety can undermine or re-energize job seekers, depending on how they process it, according to new research out of the Eller College of Management. Andy Ober Today University CommunicationsJob-Interview-Masks.jpg Gabriel said it stands to reason that anyone entering the job market for the first time during a global pandemic would be feeling added anxiety.Business and LawHealthEller College of ManagementExpertsResearch Media contact(s)Sofia Sanchez Marketing and Communications Coordinator, Eller College of Managementsofiasanchez@email.arizona.edu520-621-3851 Researcher contact(s)Allison Gabriel ...
Source: The University of Arizona: Health - July 29, 2021 Category: Universities & Medical Training Authors: andyober Source Type: research

Monitoring the binding of serotonin to silver nanoparticles: A fluorescence spectroscopic investigation
Publication date: Available online 27 August 2018Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): Bikash Chandra Swain, Padmaja Prasad Mishra, Hirdyesh Mishra, Umakanta TripathyAbstractSerotonin (5-HT) is an important monoamine neurotransmitter that plays a vital role in the regulation of various cognitive and behavioural functions including sleep, mood, pain, depression, anxiety, aggression, learning etc. From the nanotoxicity and neurotoxicity point of view, interaction studies between serotonin and nanoparticles are highly essential to develop an indispensable understanding on the effect of nano...
Source: Journal of Photochemistry and Photobiology A: Chemistry - August 29, 2018 Category: Chemistry Source Type: research

Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles.
Abstract The advent of biotechnology provided the synthesis of nanoproducts with diverse applications in the field of medicine, agriculture, food, among others. However, the toxicity of many nanoparticles (NP) currently used, which can penetrate natural systems and impact organisms, is not known. Thus, in this study, we evaluated whether the short exposure (5 days) to low concentrations of chitosan-coated zein nanoparticles (ZNP-CS) (0.2 ng/kg, 40 ng/kg, and 400.00 ng/kg) was capable of causing behavioral alterations compatible with cognitive deficit, as well as anxiety and depression-like behavior in Swiss mi...
Source: Environmental Science and Pollution Research International - February 15, 2019 Category: Environmental Health Authors: Lima VS, Guimarães ATB, da Costa Araújo AP, Estrela FN, da Silva IC, de Melo NFS, Fraceto LF, Malafaia G Tags: Environ Sci Pollut Res Int Source Type: research

Toxicity and effects of copper oxide nanoparticles on cognitive performances in rats.
Abstract There is increasing scientific evidences that the physical and chemical properties of manufactured nanoparticles lead to an increase in their bioavailability and toxicity. Among them Copper oxide nanoparticles (CuO-NPs) are widely used in different fields. However their potential adverse effects namely on brain functions are still discussed. Thus, the present study aimed to investigate the subacute oral toxicity and effects of CuO-NPs on cognitive performances in rats. Rats were randomly divided into three groups of 8 animals each, a control group received a dose 9‰ sodium chloride and the other groups ...
Source: Archives of Environmental and Occupational Health - December 25, 2019 Category: Environmental Health Authors: Ouni S, Askri D, Jeljeli M, Abdelmalek H, Sakly M, Amara S Tags: Arch Environ Occup Health Source Type: research

Anxious? Just Google it: Social ecological factors of internet search records on anxiety.
Records of Internet search are increasingly used in social science research. Three studies reported here tested (a) whether population-level anxiety is reflected in Internet search data and (b) the socioecological and cultural factors of anxiety. Using data from Japan, we found that the Google search rates of anxiety are associated with self-reported anxiety (Study 1), and that the anxiety search rates increased following a major disaster (Study 2). These findings suggest that anxiety is searched more often on the Internet when and where people are feeling anxious. However, while search rates of anxiety increased since 201...
Source: Emotion - August 15, 2019 Category: Psychiatry & Psychology Source Type: research

The influence of COVID-induced job search anxiety and conspiracy beliefs on job search effort: A within-person investigation.
New labor market entrants face significant hurdles when searching for a job, with these stressors likely amplified during the COVID-19 pandemic. Here, we consider how COVID-induced job search anxiety—feeling anxious about one’s job search due to issues imposed by the pandemic—has the potential to affect adaptive, goal-directed efforts, and maladaptive, goal-avoidant reactions. We theorize that this anxiety can prompt job seekers to engage in problem-solving pondering and affect-focused rumination, with these experiences relating to whether job seekers engage in various forms of search-related efforts the following we...
Source: Journal of Applied Psychology - June 7, 2021 Category: Psychiatry & Psychology Source Type: research

Preparation, characterization, and in vivo evaluation of Rose damascene extract loaded solid lipid nanoparticles for targeted brain delivery
AbstractAccording to a variety of experiments,Rose damascene may lead to memory enhancement and acetylcholine esterase inhibition. However,Rose damascene cannot pass through the blood-brain barrier due to its hydrophilic contents. Solid lipid nanoparticles (SLNs) are suitable carriers for brain drug delivery. Herein, SLNs were made by micro-emulsion method. Then, lactoferrin was covalently attached to the surface of the nanoparticles by amide bond interaction for targeted delivery. The nanoparticle properties and the amount of attached lactoferrin were calculated. The effect of the selected compounds on scopolamine-induced...
Source: Journal of Environmental Health Science and Engineering - July 17, 2021 Category: Environmental Health Source Type: research