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Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-Up Cohort: A pilot study.
CONCLUSIONSDPN prevalence among youth with type 2 diabetes approached rates reported in adult populations with diabetes. Our findings suggest not only that youth with diabetes are at risk for DPN but also that many already show measurable signs of DPN. PMID: 24144652 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 21, 2013 Category: Endocrinology Authors: Jaiswal M, Lauer A, Martin CL, Bell RA, Divers J, Dabelea D, Pettitt DJ, Saydah S, Pihoker C, Standiford DA, Rodriguez BL, Pop-Busui R, Feldman EL, for The SEARCH For Diabetes In Youth Study Group Tags: Diabetes Care Source Type: research

Nanoparticles to Target Atherosclerotic Plaques
This popular science article takes a look at efforts to develop nanoparticles capable of reducing the size of plaques in blood vessels produced by the processes of atherosclerosis. These plaques narrow and deform blood vessels, ultimately breaking apart to cause blockages and ruptures of blood vessels that are often fatal. Atherosclerosis is caused at root by damaged lipids that enter the circulation and lodge in blood vessel tissue. This is followed by an unfortunate set of self-reinforcing signals sent by cells in the blood vessel wall and then by immune cells that turn up to try to deal with the problem. When immune cel...
Source: Fight Aging! - May 31, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Miltefosine-loaded lipid nanoparticles: Improving miltefosine stability and reducing its hemolytic potential toward erythtocytes and its cytotoxic effect on macrophages.
Abstract The toxic effects of miltefosine on the epithelial cells of the gastrointestinal tract and its hemolytic action on erythrocytes have limited its use as an antileishmanial agent. As part of our search for new strategies to overcome the side effects of miltefosine during the treatment of leishmaniasis, we have developed stable miltefosine-loaded lipid nanoparticles in an attempt to reduce the toxic effects of the drug. We have evaluated lipid nanoparticles containing varying amounts of miltefosine and cholesterol, prepared by sonication, in terms of their physicochemical properties, preliminary stability, h...
Source: Biophysical Chemistry - July 27, 2016 Category: Chemistry Authors: da Gama Bitencourt JJ, Pazin WM, Ito AS, Barioni MB, de Paula Pinto C, Santos MA, Guimarães TH, Santos MR, Valduga CJ Tags: Biophys Chem Source Type: research

Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo
Int J Mol Sci. 2022 Jul 26;23(15):8241. doi: 10.3390/ijms23158241.ABSTRACTThe high mortality rate caused by atherosclerosis makes it necessary to constantly search for new and better treatments. In previous reports, chemically modified carbon-coated iron nanoparticles (Fe@C NPs) have been demonstrated a high biocompatibility and promising anti-plaque properties. To further investigate these effects, the interaction of these nanoparticles with the adipose tissue of Wistar rats (in vivo) and human atherosclerotic plaques (ex vivo) was studied. For the in vivo study, cobalt-chromium (CoCr) alloy tubes, which are used for coro...
Source: Atherosclerosis - July 28, 2022 Category: Cardiology Authors: Shamil Akhmedov Sergey Afanasyev Natalia Beshchasna Marina Trusova Ivan Stepanov Mariya Rebenkova Ekaterina Poletykina Yuri Vecherskiy Sergei Tverdokhlebov Evgeny Bolbasov Sascha Balakin Joerg Opitz Anatoly Yermakov Boris Kozlov Source Type: research

Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets
CONCLUSION: In the present study, cRGD-platelet@MnO/MSN@PPARα/LXRα nanoparticles with high safety and the capacity to target vulnerable plaques of AS were successfully established. They showed better performance on MRI images and treatment effects on AS by promoting cholesterol efflux through the regulation of ABCA1. These findings might address the problems of off-target effects and side effects of nanoparticle-mediated drug delivery, which will enhance the efficiency of AS treatment and provide new ideas for the clinical treatment of AS.PMID:36211824 | PMC:PMC9537012 | DOI:10.1155/2022/6006601
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Wei Zhang Zheng Lv Yupeng Zhang Subash C B Gopinath Yi Yuan Deyou Huang Liu Miao Source Type: research

Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research

Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose/streptozotocin diabetic rat model
Environ Sci Pollut Res Int. 2021 Apr 28:1-18. doi: 10.1007/s11356-021-14089-w. Online ahead of print.ABSTRACTThis research was intended to evaluate the antidiabetic effect of single or combined administration of nanoparticles of zinc oxide nanoparticles (ZnONPs), chromium oxide nanoparticles (Cr2O3NPs), and selenium nanoparticles (SeNPs), on genetic and metabolic insult in fructose/streptozotocin diabetic rat model. Type 2 diabetes mellitus was induced by feeding sixty adult male albino rats with a high fructose diet accompanied by a single i.p. injection of streptozotocin (STZ). The rats were divided into 6 groups (10 rat...
Source: Environmental Science and Pollution Research International - April 28, 2021 Category: Environmental Health Authors: Rasha M Hassan Mai Elsayed Tahany E Kholief Naglaa H M Hassanen Jehan A Gafer Yasser A Attia Source Type: research

Entrapment of silver nanoparticles in L- α-phosphatidylcholine/cholesterol-based liposomes mitigates the oxidative stress in human keratinocyte (HaCaT) cells
Eur J Pharm Biopharm. 2021 Jun 22:S0939-6411(21)00173-9. doi: 10.1016/j.ejpb.2021.06.006. Online ahead of print.ABSTRACTEncapsulation procedures are used to decrease the contact of toxic nanoparticles with cells; however, this field is still not well explored. Therefore, the aim of this paper was to evaluate the effect of encapsulation of silver nanoparticles in L-α-phosphatidylcholine/cholesterol-based liposomes on a human keratinocyte cell line (HaCaT). The homogenous (PI=0.171) spherical (∼161 nm diameter) complexes were prepared by thin film hydration with the extrusion method. The UV-Vis scan and Dynamic Light Scat...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 25, 2021 Category: Drugs & Pharmacology Authors: Bartosz Sk óra Tomasz Piechowiak Konrad A Szychowski Jan Gmi ński Source Type: research

High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis
Biomed Pharmacother. 2021 Jul 13;141:111900. doi: 10.1016/j.biopha.2021.111900. Online ahead of print.ABSTRACTThe efficiency of cholesterol efflux from cells promoted by high-density lipoproteins (HDLs) depends on HDL concentration and functional properties. The term "dysfunctional HDL" describes HDLs with impaired protective properties. Cholesterol efflux capacity (CEC) of HDL is reduced in patients with atherosclerosis, but the exact mechanisms underlying this impairment are not well characterized. Enriching HDLs with phospholipids (PLs) improves CEC. Herein, we assessed the potential of PL nanoparticles in improving HDL...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Vasily A Kudinov Tatiana I Torkhovskaya Tamara S Zakharova Galina E Morozevich Rafael I Artyushev Marina Yu Zubareva Sergey S Markin Source Type: research

Chitosan Nanoparticles in Atherosclerosis-Development to Preclinical Testing
Pharmaceutics. 2022 Apr 25;14(5):935. doi: 10.3390/pharmaceutics14050935.ABSTRACTChitosan is a natural biopolymer that is present in an abundant supply in sources such as crustacean shells, mushrooms, and insect exoskeletons. It can be used to make a variety of types of drug formulations and is generally safe to use in vivo; plus, it has inherent cholesterol-reducing properties. While an abundance of papers has tested this biopolymer in nanoparticles in cancer and diabetes research, there is a lag of usage, and hence the paucity of information, in the area of cardiovascular research, specifically in atherosclerosis, the to...
Source: Atherosclerosis - May 28, 2022 Category: Cardiology Authors: Pornsak Sriamornsak Crispin R Dass Source Type: research

Enhancing the biopharmaceutical attributes of atorvastatin calcium using polymeric and lipid-polymer hybrid nanoparticles: An approach for atherosclerosis treatment
Biomed Pharmacother. 2023 Jan 21;159:114261. doi: 10.1016/j.biopha.2023.114261. Online ahead of print.ABSTRACTAtherosclerosis is associated with inflammation in the arteries, a significant cause of heart attacks and strokes. Although statin therapy can reduce the chances of atherosclerotic plaque formation, they need to be administered in high doses due to low systemic bioavailability and encountered with side effects. To overcome these challenges, we developed nanoparticles using biocompatible and biodegradable lipids and polymers for improving systemic drug absorption and therapeutic response. The polymeric nanoparticles...
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Miao Liu Tingchao Gao Lei Jiang Shunqi Li Bolun Shi Fangxu Li Source Type: research