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Total 151079 results found since Jan 2013.

Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia
This study is the first to describe nanoparticles that enable systemically delivered magnetic hyperthermia for endometriosis treatment. When subjected to an alternating magnetic field (AMF), these hexagonal iron-oxide nanoparticles exhibit extraordina ry heating efficiency that is 6.4× greater than their spherical counterparts. Modifying nanoparticles with a peptide targeted to vascular endothelial growth factor receptor 2 (VEGFR-2) enhances their endometriosis specificity. Studies in mice bearing transplants of macaque endometriotic tissue reve al that, following intravenous injection at a low dose (3 mg per kg), these ...
Source: Small - April 18, 2022 Category: Nanotechnology Authors: Youngrong Park, Ananiya A. Demessie, Addie Luo, Olena R. Taratula, Abraham S. Moses, Peter Do, Leonardo Campos, Younes Jahangiri, Cory R. Wyatt, Hassan A. Albarqi, Khashayar Farsad, Ov D. Slayden, Oleh Taratula Tags: Research Article Source Type: research

Using Chitosan-Coated Polymeric Nanoparticles-Thermosensitive Hydrogels in association with Limonene as Skin Drug Delivery Strategy
This study reports the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan for the sustained release and topicality of benzocaine (BZC) and topical delivery. BZC PLGA nanoparticles or nonencapsulated drugs were further incorporated into Poloxamer hydrogels (Pluronic™ F-127). The nanoparticles showed a mean diameter of 380 ± 4 nm, positive zeta potential after coating with chitosan (23.3 ± 1.7 mV), and high encapsulation efficiency (96.7 ± 0.02%). Cellular viability greater than 70% for both fibroblasts and keratinocytes was observed after treatment with nanoparticles, which is in ac...
Source: Biomed Res - April 18, 2022 Category: Research Authors: Estef ânia V R Campos Patr ícia L F Proença Tais G da Costa Renata de Lima Leonardo F Fraceto Daniele R de Araujo Source Type: research

Glucose sensitive konjac glucomannan/concanavalin A nanoparticles as oral insulin delivery system
Int J Biol Macromol. 2022 Jan 13:S0141-8130(22)00057-5. doi: 10.1016/j.ijbiomac.2022.01.048. Online ahead of print.ABSTRACTCompared with injection, oral drug delivery is a better mode of administration because of its security, low pain and simplicity. Insulin is the first choice for clinical treatment of type 1 diabetes, but, because insulin inability to resist gastrointestinal (GI) digestion results in poor oral bioavailability of insulin. Herein, we developed a targeted oral delivery system for diabetes. ConA-INS-KGM nanoparticles were prepared, loaded with insulin, fabricated from konjac glucomannan (KGM) and concanaval...
Source: International Journal of Biological Macromolecules - January 17, 2022 Category: Biochemistry Authors: Mingze Xu Jinpeng Huang Siyuan Jiang Jiecheng He Zhen Wang Han Qin Yan-Qing Guan Source Type: research

On RSS Readers, Divorce and Marriage
In just a few days, Google Reader will be history.  I've used it to create over 18,000 Tweets, so yes, I will miss Google Reader.  The end has pushed me into a divorce (or maybe it's just a separation?!) — from Google.  I describe my Google divorce as kind of like when a married couple with children decide to separate … they still have to see their exes for the sake of the kids (and I still have my blogs with Google's Blogger, for now anyway), and it may be a cordial, but not quite blissful separation, but is still necessary.A number of my fellow diabetes blogging peers have already migrated from Google'...
Source: Scott's Web Log - June 28, 2013 Category: Diabetes Authors: Scott S Source Type: blogs

Abstract IA18: Targeted polymeric nanoparticles: From academic innovations to clinical trials and lessons learned
A variety of organic and inorganic materials have been utilized to generate nanoparticles for drug delivery applications, including polymeric nanoparticles, dendrimers, nanoshells, liposomes, nucleic acid based nanoparticles, magnetic nanoparticles, and virus nanoparticles. The two most commonly used systems are polymeric nanoparticles and liposomes [1, 2]. Controlled release polymer technology has impacted virtually every branch of medicine, including ophthalmology, pulmonary, pain medicine, endocrinology, cardiology, orthopedics, immunology, neurology and dentistry, with several of these systems in clinical practice toda...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Omid C. Farokhzad Tags: Drug Delivery and Nanomedicine Source Type: research

Zinc oxide nanoparticles synthesized from Fraxinus rhynchophylla extract by green route method attenuates the chemical and heat induced neurogenic and inflammatory pain models in mice
Publication date: Available online 5 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Zhi Wang, Bin Que, Jianhui Gan, Hao Guo, Qiang Chen, Lina Zheng, Najat Marraiki, Abdullah M. Elgorban, Yi ZhangAbstractFraxinus rhynchophylla belongs to the family of Oleaceae and also called as Chinese ash wood possesses various pharmacological properties such as neuroprotective, antimicrobial, anti-inflammatory, etc. Therefore we synthesized ZnO nanoparticles using Fraxinus rhynchophylla wood extract as reducing and capping agent. The synthesized nanoparticles were characterized with the aid of UV-Spe...
Source: Journal of Photochemistry and Photobiology B: Biology - November 6, 2019 Category: Speech-Language Pathology Source Type: research

An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles.
Abstract Hydrogel scaffolds have been frequently utilized due to their ability to absorb water and develop similar body cell conditions. Specific drug delivery to the tissues ensures less adverse side effects and more efficiency. In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized. Nanoparticles were incorporated at 3.5, 4.5 and 5.5% (w/v). Hydrogels containing the same amounts of the meloxicam solution were also prepared. Gelation time, swelling and degradation of the hydrog...
Source: International Journal of Biological Macromolecules - February 2, 2020 Category: Biochemistry Authors: Fattahpour S, Shamanian M, Tavakoli N, Fathi M, Sadeghi-Aliabadi H, Sheykhi SR, Fesharaki M, Fattahpour S Tags: Int J Biol Macromol Source Type: research

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model.
In conclusion, the findings of this study proved the beneficial effects of zinc oxide nanoparticles from V. amygdalina against the different pain and inflammation-induced mice. Hence, it was clear that the zinc nanoparticles from V. amygdalina could be promising antinociceptive and anti-inflammatory agent in the future. PMID: 32815404 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - August 22, 2020 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Green synthesis of Ag nanoparticles using elm pod polysaccharide for catalysis and bacteriostasis
In this study, elm pod polysaccharide (EPP) was extracted from elm pods using hot water extraction for the first time. Biocompatible EPP-stabilized silver nanoparticles (EPP-Agn NPs) were prepared by using a green synthesis method. The EPP-Ag25 NPs had a hydrodynamic size of 40.9 nm and a highly negative surface charge of -27.4 mV. Furthermore, EPP-Ag25 NPs exhibited high catalytic activity for the reduction of 4-nitrophenol, and the catalytic reaction followed a pseudo-first order kinetic equation. More importantly, the inhibition rate of EPP-Ag25 NPs on Escherichia coli was 71 % when samples were treated with an 808 nm l...
Source: International Journal of Biological Macromolecules - June 12, 2022 Category: Biochemistry Authors: Mengmeng He Zengsheng Han Ying Liang Han Zhao Xianbing Ji Guanglong Ma Yanshuai Cui Longgang Wang Source Type: research

Assessing the effects of silver nanoparticles on the ecophysiology of Gammarus roeseli
Aquat Toxicol. 2023 Feb 10;256:106421. doi: 10.1016/j.aquatox.2023.106421. Online ahead of print.ABSTRACTBeing part of the macrobenthic fauna, gammarids are efficient indicators of contamination of aquatic ecosystems by nanoparticles that are likely to sediment on the bottom. The present study investigates the effects of silver nanoparticles (nAg) on ecophysiological functions in Gammarus roeseli by using a realistic scenario of contamination. Indeed, an experiment was conducted during 72 h, assessing the effects of 5 silver nAg from 10 to 100 nm diluted at concentrations of maximum 5 µg L-1 in a natural water retrieved f...
Source: Aquatic Toxicology - February 22, 2023 Category: Toxicology Authors: Jennifer Andre ï Fran çois Guérold Jonathan Bouquerel Simon Devin Kahina Mehennaoui Sebastien Cambier Arno C Gutleb Laure Giamb érini Sandrine Pain-Devin Source Type: research

Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research