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Total 69618 results found since Jan 2013.
Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
AbstractBACKGROUNDNanotechnology involves the engineering of structures on a molecular level. Nanomedicine and nano-delivery systems have been designed to deliver therapeutic agents to a target site or organ in a controlled manner, maximizing efficacy while minimizing off-target effects of the therapeutic agent administered. In both reproductive medicine and obstetrics, developing innovative therapeutics is often tempered by fears of damage to the gamete, embryo or developing foetus or of negatively impacting a woman ’s reproductive potential. Thus, nanomedicine delivery systems may provide alternative targeted intervent...
Source: Human Reproduction Update - December 6, 2020 Category: OBGYN Source Type: research
Toxicity of silver nanoparticles on Endometrial Receptivity in Female Mice
Can J Physiol Pharmacol. 2021 Jul 20. doi: 10.1139/cjpp-2021-0094. Online ahead of print.ABSTRACTNanoparticles (NPs) have many toxic effects on fertility and can prevent successful implantation by affecting the maternal uterine tissue. Herein, by deploying thirty female NMRI mice, the effect of silver nanoparticles on the endometrium and implantation has been investigated. Using spherical silver nanoparticles of a diameter of 18-30 nm at doses of 2 and 4 mg/kg, mice in both groups were treated. Then, female mice mated with male mice. Endometrial tissue was extracted 4.5 days later. On the fourth day of pregnancy, the mice ...
Source: Canadian Journal of Physiology and Pharmacology - July 20, 2021 Category: Drugs & Pharmacology Authors: Marziyeh Ajdary Sahar Eghbali Vahid Pirhajati Mahabadi Fariborz Keyhanfar Rajender S Varma Source Type: research
Placental cell translocation of folate-conjugated pullulan acetate non-spherical nanoparticles
This study aims to construct a non-spherical drug delivery system based on folate-conjugated pullulan acetate (FPA) for placental targeting and translocation. By adjusting the initial solvent system, FPA nanoparticles with different morphologies were prepared using dialysis method without a surfactant. Cytotoxicity and lactate dehydrogenase release assays indicated the good biocompatibility of FPA nanoparticles in BeWo b30 cells. Cellular uptake and in vitro placental barrier transportation studies showed that FPA nanoparticles entered the cells and transported across the cell monolayer, benefiting from the active target e...
Source: Colloids and Surfaces - May 22, 2022 Category: Biotechnology Authors: Ziwen Jiang Hongbo Tang Qingqing Xiong Min Li Yinmei Dai Zhimin Zhou Source Type: research
Health Effects and Safety Assurance of Nanoparticles in Vulnerable Generations
Biol Pharm Bull. 2022;45(7):806-812. doi: 10.1248/bpb.b22-00277.ABSTRACTNanoparticles have a variety of useful functions. They have already been put to practical use in products in many industrial arenas, such as the cosmetics and food fields. Therefore, we cannot avoid the unintentional nanoparticle exposure of vulnerable people such as pregnant women and infants, and the importance of evaluating the safety of such vulnerable generations, who are highly sensitive to chemical substances, has been pointed out worldwide. However, it is still difficult to determine the hazards posed by nanoparticle exposure in everyday life. ...
Source: Biological and Pharmaceutical Bulletin - July 5, 2022 Category: Drugs & Pharmacology Authors: Kazuma Higashisaka Source Type: research
