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Drug: Aspirin

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Total 5471 results found since Jan 2013.

Electrospun nanofibers containing chitosan-stabilized bovine serum albumin nanoparticles for bone regeneration
Colloids Surf B Biointerfaces. 2022 Jun 30;217:112680. doi: 10.1016/j.colsurfb.2022.112680. Online ahead of print.ABSTRACTBone tissue engineering is becoming a key approach in bone repair and regeneration. In the present study, we fabricated a nanofiber scaffold containing chitosan-stabilized bovine serum albumin (BSA) nanoparticles for the delivery of abaloparatide and aspirin (ASA). The chitosan-stabilized BSA nanoparticles acted as a release barrier for the encapsulated abaloparatide. Polymeric nanofibers were produced by electrospinning from a mixture of abaloparatide-loaded nanoparticles, ASA, poly(ε-caprolactone) (P...
Source: Colloids and Surfaces - July 8, 2022 Category: Biotechnology Authors: Peng Lin Wenjuan Zhang Daiyun Chen Yanran Yang Tongke Sun Hao Chen Jun Zhang Source Type: research

Nanoparticles used to treat damaged arteries
Conclusion This exciting study in mice has shown that nanoparticles can be manufactured to target the plaques that form in atherosclerosis, and help stabilise them. It appears that the nanoparticles honed in on the plaques, rather than affecting other organs such as the spleen or liver, which gives an early indication that there may not be substantial side effects. However, it will be necessary to see if the same holds true for other organs. As with all mice studies, they give an indication of the likely biological effects of a new technique, but they do not provide the full picture of what may happen in humans, especially...
Source: NHS News Feed - February 19, 2015 Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Source Type: news

Fabrication of SnO2/porous silica/polyethyleneimine nanoparticles for pH-responsive drug delivery
Publication date: 1 February 2016 Source:Materials Science and Engineering: C, Volume 59 Author(s): Na Cao, Miao Li, Yanbao Zhao, Li Qiu, Xueyan Zou, Yu Zhang, Lei Sun To create novel nanocarriers for achieving excellent drug delivery performance, pH-responsive fluorescent porous silica (PS) nanocarriers were developed by encapsulating SnO2 nanoparticles and coating polyethyleneimine (PEI) layer. SnO2/porous silica (SnO2/PS) nanoparticles have an average diameter of 80nm and center-radial large pore channels. The large channels endow them high surface area with a Brunauer–Emmett–Teller (BET) area of 939m2 g−...
Source: Materials Science and Engineering: C - October 24, 2015 Category: Materials Science Source Type: research

Abstract 1900: Mechanistic study of aspirin, folic acid and calcium (AFAC) combinations delivered using targeted polymeric nanoparticles in colon cancer prevention
The objective of the present study was to evaluate the mechanisms of action of orally administered, colon targeted chemopreventive regimens aspirin (ASP), folic acid (FA) and calcium (Ca) alone and in combination AFAC (ASP+FA+Ca) in in-vitro and in-vivo rat model. We used colon cancer cells, HCT-116 and HT-29 as the in-vitro model. For colon targeting, ASP and FA was encapsulated in polylactide-co-glycolide (PLGA 50:50) polymer nanoparticles. Our previous studies demonstrated that combination of ASP (1mM), FA (1.5mM) and Ca (1.5mM) showed synergistic effect on inhibition of colon cancer cell viability. Follow-up study on...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Thakkar, A., Chenreddy, S., Wang, J., Prabhu, S. Tags: Prevention Research Source Type: research

Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
Front Mol Biosci. 2022 Jan 28;8:788279. doi: 10.3389/fmolb.2021.788279. eCollection 2021.ABSTRACTBreast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves disease symptoms and severity. Here, mesoporous silica nanoparticles (MNPs) have been used to deliver aspirin to the tumor location. MNP-based aspirin in folic acid (F)-conjugated polydopamine (MNP-Asp-PD-PG-F) vehicles are prepared fo...
Source: Molecular Medicine - February 21, 2022 Category: Molecular Biology Authors: Fariha Kanwal Mingming Ma Muhammad Fayyaz Ur Rehman Fahim-Ullah Khan Shai E Elizur Aima Iram Batool Chi Chiu Wang Tahira Tabassum Changrui Lu Yao Wang Source Type: research

Preparation of attapulgite nanoparticles-based hybrid monolithic column with covalent bond for hydrophilic interaction liquid chromatography.
Abstract In current study, an attapulgite nanoparticles-based hybrid monolith was prepared by crosslinking 3-trimethoxysilylpropyl methacrylate modified attapulgite nanoparticles with acrylamide and N, N'-methylenebisacrylamide. The crosslinking of attapulgite into the hybrid monolithic matrix has notable increased the column efficiency of adenosine comparing with the neat one without attapulgite. The resulting hybrid monoliths showed good permeability and good mechanical stability. It was further applied for separation of polar compounds by hydrophilic interaction chromatography (HILIC). The key factors affecting...
Source: Talanta - August 9, 2018 Category: Chemistry Authors: Chai M, Chen Y, Xuan R, Ma J, Wang T, Qiu D, Zhang L, Zhang Y Tags: Talanta Source Type: research

Surface modification of luminescent Ln(III) fluoride core-shell nanoparticles with acetyl salicylic acid (aspirin) - synthesis, spectroscopic and in vitro hemocompatibility studies.
This study demonstrates that the LaF3: Tb3+ 5%, Ce3+ 10%@SiO2-NH2 nanoparticles with acetyl salicylic acid (aspirin) coated on the surface, are very good precursors for multifunctional drug-delivery systems or bio-imaging probe, which can be used safely in potential biomedical applications. PMID: 32510839 [PubMed - as supplied by publisher]
Source: ChemMedChem - June 7, 2020 Category: Chemistry Authors: Kwiatek D, Mrówczyńska LM, Stopikowska N, Runowski M, Lesicki A, Lis S Tags: ChemMedChem Source Type: research

Antifungal Potential of Green Synthesized Magnetite Nanoparticles Black Coffee –Magnetite Nanoparticles Against Wilt Infection by Ameliorating Enzymatic Activity and Gene Expression in Solanum lycopersicum L.
Tomato plants are prone to various biotic and abiotic stresses. Fusarium wilt is one of the most devasting diseases of tomatoes caused by Fusarium oxysporum f. sp. lycopersici, causing high yield and economic losses annually. Magnetite nanoparticles (Fe3O4 NPs) are one of the potent candidates to inhibit fungal infection by improving plant growth parameters. Spinach has been used as a starting material to synthesize green-synthesized iron oxide nanoparticles (IONPs). Various extracts, i.e., pomegranate juice, white vinegar, pomegranate peel, black coffee (BC), aloe vera peel, and aspirin, had been used as reducing/stabiliz...
Source: Frontiers in Microbiology - March 3, 2022 Category: Microbiology Source Type: research

Synthesis of charged chitosan nanoparticles as functional biolubricant
Colloids Surf B Biointerfaces. 2021 Jul 15;206:111973. doi: 10.1016/j.colsurfb.2021.111973. Online ahead of print.ABSTRACTOsteoarthritis has been a major disease in recent years, which is mainly related to the breakdown of the lubrication function of the cartilage sliding interface, along with the inflammation of the joint capsule. In this paper, one kind of novel biomimetic nanoparticles (NPs) lubricant, named CS-PS, is synthesized through chemically grafting hydrophilic sulfonic acid (SO3-) groups onto the surface of biocompatible and biodegradable chitosan (CS) NPs. Compared with control CS NPs, the as-synthesized CS-PS...
Source: Colloids and Surfaces - July 25, 2021 Category: Biotechnology Authors: Lumin Yang Xiaoduo Zhao Jing Zhang Shuanhong Ma Lei Jiang Qiangbing Wei Meirong Cai Feng Zhou Source Type: research

Teratogenicity of 30  nm Aluminum Oxide Nanoparticles (Al < sub > 2 < /sub > O < sub > 3 < /sub > NPs) in Rats by Gavage
This study was aimed to evaluate the teratogenicity of Al2O3NPs in Sprague Dawley (SD) rats by gavage and to compare the effects of Al2O3NPs to those of equivalent dose of microscale aluminum oxide (bulk Al2O3). Sixty pregnant rats were randomly divided into 5 groups and treated with 100 and 200 mg/kg body weight (bw) Al2O3NPs (30 nm), 200 mg/kg bulk Al2O3, deionized water (as the negative control), and 300 mg/kg aspirin (as the positive control). Rats were exposed daily by oral gavage from the 7th day of gestation for 10 consecutive days and sacrificed on the 20th day of gestation. Results of the study showed that there w...
Source: Biological Trace Element Research - November 11, 2021 Category: Biology Authors: Yuqiu Gao Pingjing Wen Huafeng Chen Yujia Wei Haichen Cui Jinfeng Ma Jinyue Li Guangqiu Qin Source Type: research

Visual colorimetric sensor for nitroguanidine detection based on hydrogen bonding-induced aggregation of uric acid-functionalized gold nanoparticles
Talanta. 2023 Apr 23;260:124585. doi: 10.1016/j.talanta.2023.124585. Online ahead of print.ABSTRACTA colorimetric assay is proposed for the quantification of nitroguanidine (NQ), based on triggering the aggregation of uric acid-modified gold nanoparticles (AuNPs@UA) by intermolecular hydrogen bonding interaction between uric acid (UA) and NQ. The red-to-purplish blue (lavender) color change of AuNPs@UA with increasing NQ concentrations could be perceived with the naked eye or detected by UV-vis spectrophotometry. The absorbance versus concentration correlation gave a linear calibration curve in the range of 0.6-3.2 mg L-1 ...
Source: Talanta - April 29, 2023 Category: Chemistry Authors: Kader Can Ziya Can Ay şem Üzer Re şat Apak Source Type: research

Abstract 2621: Preclinical systemic toxicity evaluation of chitosan-solid lipid nanoparticles encapsulated aspirin, curcumin and free sulforaphane (ACS) combinations in BALB/c mice
The present study aims to evaluate the preclinical systemic toxicity profile of chitosan-solid lipid nanoparticles (c-SLNs) encapsulated aspirin (ASP), curcumin (CUR), and free sulforaphane (SFN) combination (ACS) in BALB/c mice. Recently, we demonstrated pancreatic cancer chemopreventive efficacy using ACS-SLNs delivery system in the BOP carcinogen induced pancreatic cancer hamster model. In order to develop safe ACS c-SLNs for clinical applications, it is vital to investigate their toxicity. Thus, we performed acute 3-day, sub-acute 28-day and sub-chronic 90-day toxicity studies of ACS c-SLNs in the BALB/c mice model. Th...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Thakkar, A., Chenreddy, S., Wang, J., Prabhu, S. Tags: Experimental and Molecular Therapeutics Source Type: research

Combined Chemo-Anti-Inflammatory Prodrugs and Nanoparticles
SynlettDOI: 10.1055/s-0035-1561440Combining multiple drugs in one platform has the ability to override the limitations of singly administered therapeutic and may provide potential alternative treatment options for aggressive prostate cancer resistant to conventional chemotherapy. For in vivo applications, combination therapeutics should be engineered to include nanoparticles for efficacious delivery. Here, we discuss the aspects of combining chemotherapy with anti-inflammatory drugs for metastatic castration resistant prostate cancer. We highlight the concept of combining cisplatin and Aspirin in a single platinum(IV) prod...
Source: Synlett - April 21, 2016 Category: Chemistry Authors: Pathak, Rakesh K.Dhar, Shanta Tags: synpacts Source Type: research