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Drug: Insulin

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Total 39295 results found since Jan 2013.

Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes. PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research

Administration of Silver Nanoparticles in Diabetes Mellitus: A  Systematic Review and Meta-analysis on Animal Studies
Biol Trace Elem Res. 2021 Jun 10. doi: 10.1007/s12011-021-02776-1. Online ahead of print.ABSTRACTBiological features of silver nanoparticles in rising the insulin level of diabetic animal models were considered in recent years, which resulted in decreasing hyperglycemia condition. We reviewed the published literature to investigate the possible role of silver nanoparticles (Ag-NPs) throughout the treatment of diabetes mellitus in animal studies. In this systematic review and meta-analysis, we performed a search throughout the English literature of electronic databases, including Scopus, PubMed, and ISI Web of Science, up t...
Source: Biological Trace Element Research - June 11, 2021 Category: Biology Authors: Farnaz Torabian Arash Akhavan Rezayat Mohammad Ghasemi Nour Atefeh Ghorbanzadeh Sara Najafi Amirhossein Sahebkar Zahra Sabouri Majid Darroudi Source Type: research

Using Robots and Artificial Intelligence to Search for New Medicines
Courtesy of Dr. Adam Gormley. Adam Gormley, Ph.D., describes himself as a creative and adventurous person—albeit, not creative in the traditional sense. “Science allows me to be creative; to me, it’s a form of art. I love being outdoors, going on sailing trips, and spending time adventuring with my family. Research is the same—it’s an adventure. My creative and adventurous sides have combined into a real love for science,” he says. Dr. Gormley currently channels his passion for science into his position as an assistant professor of biomedical engineering at Rutgers University in Piscataway, New Jersey. Lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 24, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Medicines Profiles Source Type: blogs

Recent advances of polysaccharide-based nanoparticles for oral insulin delivery.
Abstract Diabetes mellitus is a highly prevalent metabolic and chronic disease affecting millions of people in the world. The most common route of insulin therapy is the subcutaneous injection due to its low bioavailability and enzymatic degradation. The search for effective and high patient compliance insulin delivery systems has been a major challenge over many decades. The polysaccharide-based nanoparticles as delivery vehicles for insulin oral administration have recently attracted substantial interests. The present review highlights the recent advances on the development of nanoparticles prepared from polysac...
Source: International Journal of Biological Macromolecules - August 28, 2018 Category: Biochemistry Authors: Hu Q, Luo Y Tags: Int J Biol Macromol Source Type: research

Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose/streptozotocin diabetic rat model
Environ Sci Pollut Res Int. 2021 Apr 28:1-18. doi: 10.1007/s11356-021-14089-w. Online ahead of print.ABSTRACTThis research was intended to evaluate the antidiabetic effect of single or combined administration of nanoparticles of zinc oxide nanoparticles (ZnONPs), chromium oxide nanoparticles (Cr2O3NPs), and selenium nanoparticles (SeNPs), on genetic and metabolic insult in fructose/streptozotocin diabetic rat model. Type 2 diabetes mellitus was induced by feeding sixty adult male albino rats with a high fructose diet accompanied by a single i.p. injection of streptozotocin (STZ). The rats were divided into 6 groups (10 rat...
Source: Environmental Science and Pollution Research International - April 28, 2021 Category: Environmental Health Authors: Rasha M Hassan Mai Elsayed Tahany E Kholief Naglaa H M Hassanen Jehan A Gafer Yasser A Attia Source Type: research

Glucose sensitive konjac glucomannan/concanavalin A nanoparticles as oral insulin delivery system
Int J Biol Macromol. 2022 Jan 13:S0141-8130(22)00057-5. doi: 10.1016/j.ijbiomac.2022.01.048. Online ahead of print.ABSTRACTCompared with injection, oral drug delivery is a better mode of administration because of its security, low pain and simplicity. Insulin is the first choice for clinical treatment of type 1 diabetes, but, because insulin inability to resist gastrointestinal (GI) digestion results in poor oral bioavailability of insulin. Herein, we developed a targeted oral delivery system for diabetes. ConA-INS-KGM nanoparticles were prepared, loaded with insulin, fabricated from konjac glucomannan (KGM) and concanaval...
Source: International Journal of Biological Macromolecules - January 17, 2022 Category: Biochemistry Authors: Mingze Xu Jinpeng Huang Siyuan Jiang Jiecheng He Zhen Wang Han Qin Yan-Qing Guan Source Type: research

Structural view of insulin adsorption on the multiple sizes of Cu nanoparticles; molecular dynamics simulation study
Arch Biochem Biophys. 2022 Apr 12:109219. doi: 10.1016/j.abb.2022.109219. Online ahead of print.ABSTRACTCopper nanoparticles with different sizes cause significant changes in humans, and their interaction with biological molecules such as proteins is one of molecular biology's most critical and difficult challenges. One of the valuable tools for understating the mechanisms of different protein-nanoparticle interactions are molecular dynamics simulations. The present work attempts to understand how insulin interaction mechanisms Cu nanoparticles of different sizes (2, 6, and 10 nm) may occur with the molecular dynamics simu...
Source: Archives of Biochemistry and Biophysics - April 15, 2022 Category: Biochemistry Authors: Masoumeh Jomhori Baloch Hamid Mosaddeghi Majid Jamshidian-Mojaver Source Type: research

Therapeutic Potential of MgO and MnO Nanoparticles Within the Context of Thyroid Profile and Pancreatic Histology in a Diabetic Rat Model
Dose Response. 2022 Sep 21;20(3):15593258221128743. doi: 10.1177/15593258221128743. eCollection 2022 Jul-Sep.ABSTRACTMagnesium oxide (MgO) and manganese oxide (MnO) have been reported to be effective against Diabetes Mellitus (DM). However, their nanoparticulate form has not been evaluated for antidiabetic effect. MgO and MnO nanoparticles (15-35 nm) were synthesized and subsequently characterized by ultraviolet-visible spectroscopy (UV-VIS), zeta sizer, and scanning electron microscopy. 6-7 weeks old rats weighing 200-220 mg were divided into 07 equal groups (n = 8), namely, negative control (NC), positive control (PC), s...
Source: Dose Response - September 26, 2022 Category: Drugs & Pharmacology Authors: Arslan Shaukat Ghulam Hussain Shahzad Irfan Muhammad Umar Ijaz Haseeb Anwar Source Type: research

Novel Gold Nanoparticles: Green Synthesis with Eryngium thyrsoideum Boiss Extract, Characterization, and In Vivo Investigations on Inflammatory Gene Expression and Biochemical Parameters in Type 2 Diabetic Rats
Biol Trace Elem Res. 2021 Jul 15. doi: 10.1007/s12011-021-02819-7. Online ahead of print.ABSTRACTIn this work, we synthesized and reported gold nanoparticles (Au NPs) with Eryngium thyrsoideum Boiss plant extract for first time. The plant extract has important effect as reducing and stabilizing agent for preparation of Au nanoparticles. The synthesized gold nanoparticles were characterized with FT-IR, UV-vis, XRD, SEM, and TEM analyses. All analyses confirmed successful synthesis of gold nanoparticles with high purity. The antidiabetic activity of synthesized Au NPs was investigated on type 2 diabetic rats by studying thei...
Source: Biological Trace Element Research - July 15, 2021 Category: Biology Authors: Fariba Mahmoudi Farzaneh Mahmoudi Khadijeh Haghighat Gollo Mostafa M Amini Source Type: research

Preconditioned human dental pulp stem cells with cerium and yttrium oxide nanoparticles effectively ameliorate diabetic hyperglycemia while combatting hypoxia
CONCLUSION: The achieved results highlight the promising role of the Cerium & Yttrium oxide nanoparticles in promoting the generation of IPCs that have the ability to combat hypoxia and govern diabetes mellitus.PMID:34656024 | DOI:10.1016/j.tice.2021.101661
Source: Tissue and Cell - October 16, 2021 Category: Cytology Authors: Hanaa H Ahmed Hadeer A Aglan Nadia S Mahmoud Riham M Aly Source Type: research