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Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics
Adv Colloid Interface Sci. 2023 Apr 12;315:102903. doi: 10.1016/j.cis.2023.102903. Online ahead of print.ABSTRACTThe respiratory tract is one of the most accessible ones to exogenous nanoparticles, yet drug delivery by their means to it is made extraordinarily challenging because of the plexus of aerodynamic, hemodynamic and biomolecular factors at cellular and extracellular levels that synergistically define the safety and efficacy of this process. Here, the use of inorganic nanoparticles (INPs) for inhalable diagnostics and therapies of the lung is viewed through the prism of the history of studies on the interaction of ...
Source: Advances in Colloid and Interface Science - April 21, 2023 Category: Chemistry Authors: Vuk Uskokovi ć Source Type: research

Next Phase of NIH Preprint Pilot Launching Soon
Last month, the National Library of Medicine (NLM)announced plans to extend its NIH Preprint Pilot in PubMed Central (PMC) and PubMed beyond COVID-19 to encompass all preprints reporting on NIH-funded research. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award, contract, or intramural program and posted to aneligible preprint server on or after January 1, 2023.In preparation for the launch of this second phase, we have updated PMC and PubMed site features to help users of these databases incorporate the increased volume of preprints into their discovery workflows. S...
Source: PubMed Central News - January 10, 2023 Category: Databases & Libraries Source Type: news

Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news

On RSS Readers, Divorce and Marriage
In just a few days, Google Reader will be history.  I've used it to create over 18,000 Tweets, so yes, I will miss Google Reader.  The end has pushed me into a divorce (or maybe it's just a separation?!) — from Google.  I describe my Google divorce as kind of like when a married couple with children decide to separate … they still have to see their exes for the sake of the kids (and I still have my blogs with Google's Blogger, for now anyway), and it may be a cordial, but not quite blissful separation, but is still necessary.A number of my fellow diabetes blogging peers have already migrated from Google'...
Source: Scott's Web Log - June 28, 2013 Category: Diabetes Authors: Scott S Source Type: blogs

Abstract IA18: Targeted polymeric nanoparticles: From academic innovations to clinical trials and lessons learned
A variety of organic and inorganic materials have been utilized to generate nanoparticles for drug delivery applications, including polymeric nanoparticles, dendrimers, nanoshells, liposomes, nucleic acid based nanoparticles, magnetic nanoparticles, and virus nanoparticles. The two most commonly used systems are polymeric nanoparticles and liposomes [1, 2]. Controlled release polymer technology has impacted virtually every branch of medicine, including ophthalmology, pulmonary, pain medicine, endocrinology, cardiology, orthopedics, immunology, neurology and dentistry, with several of these systems in clinical practice toda...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Omid C. Farokhzad Tags: Drug Delivery and Nanomedicine Source Type: research

Peas in a Pod? The Similarities between UFPs and Nanoparticles Yield Research Opportunities
PDF Version (514 KB) About This Article Published: 20 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Nanomaterials Versus Ambient Ultrafine Particles: An Oppor...
Source: EHP Research - October 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles
Abstract Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano‐biotechnology field as they can provide easily accessible information on the performance of nanoparticles without using animal models. Considering that many countries have put restrictions on animals testing, which will only tighten in the future as seen by the recent developments in the Netherlands, 3D models will become an even more valuable tool. Here, an overview on MCTS is provided, focusing on their use in cancer research as most ...
Source: Small - February 16, 2018 Category: Nanotechnology Authors: Hongxu Lu, Martina H. Stenzel Tags: Review Source Type: research

Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies.
Abstract Significant research and preclinical investment in cancer nanomedicine has produced several products, which have improved cancer care. Nevertheless, there exists a perception that cancer nanomedicine 'has not lived up to its promise' because the number of approved products and their clinical performance are modest. Many of these analyses do not consider the long clinical history and many clinical products developed from iron oxide nanoparticles. Iron oxide nanoparticles have enjoyed clinical use for about nine decades demonstrating safety, and considerable clinical utility and versatility. FDA-approved ap...
Source: Advanced Drug Delivery Reviews - June 26, 2020 Category: Drugs & Pharmacology Authors: Soetaert F, Korangath P, Serantes D, Fiering S, Ivkov R Tags: Adv Drug Deliv Rev Source Type: research

A brief history of long circulating nanoparticles
Adv Drug Deliv Rev. 2022 Jul 4:114396. doi: 10.1016/j.addr.2022.114396. Online ahead of print.ABSTRACTThe propensity of the hepatic macrophages (Kupffer cells) to rapidly intercept particulate materials from the blood has been frustrating in redirecting intravenously injected nanomedicines to pathological sites in sufficient quantities to exert appropriate pharmacological effect. The development of long circulating nanoparticles has offered unprecedented opportunities for controlled drug release within vasculature and for drug delivery to sites other than Kupffer cells. These developments were based on mechanistic understa...
Source: Advanced Drug Delivery Reviews - July 7, 2022 Category: Drugs & Pharmacology Authors: H B Haroon A C Hunter Z S Farhangrazi S M Moghimi Source Type: research

A Perspective on Therapeutic Applications and Strategies to Mitigate Toxicity of Metallic Nanoparticles
Curr Pharm Des. 2023 Jan 9. doi: 10.2174/1381612829666230109111635. Online ahead of print.ABSTRACTMetallic nanoparticles (MNPs) have been widely used for diagnostic and therapeutic purposes in clinical practice. A number of MNP formulations are being investigated in clinical trials for various applications. This increase in the use of NPs results in higher exposure to humans, leading to toxicity issues. Hence, it is necessary to determine the possible undesirable effects of the MNPs after in-vivo application and exposure. One of the main reasons for the toxicity of MNPs is the release of their respective metallic ions thro...
Source: Current Pharmaceutical Design - January 10, 2023 Category: Drugs & Pharmacology Authors: Arjunan Karuppaiah Divakar Selvaraj Mohan Sellappan Arumugam Nagarajan Dinesh Babu Habibur Rahman Thiagarajan Madheswaran Bharadhan Bose Tamilselvan Natrajan Source Type: research

Evolution of a Search: The Use of Dynamic Twitter Searches During Superstorm Sandy
Conclusion The most important lesson learned from Superstorm Sandy was the need for a dynamic and flexible monitoring process and strategy to understand and respond quickly to health needs in the areas impacted by Superstorm Sandy. Search strategies should change as frequently as the unfolding event. The inability to adapt to a changing situation ensures stale and stagnant terminology and search results. Twitter lists and Boolean searches should be used together to maximize situational awareness. The most important information comes from the impacted population, whether news, local government or local citizens. These are t...
Source: PLOS Currents Disasters - September 26, 2014 Category: Global & Universal Authors: Sara Harris Smith Source Type: research

Lessons from a systematic literature search on diagnostic DNA methylation biomarkers for colorectal cancer: how to increase research value and decrease research waste
DiscussionThis systematic literature search revealed that major requirements to develop clinically relevant diagnostic CRC DNA methylation markers are often lacking. To avoid the resulting research waste, clinical needs, intended biomarker use and independent validation should be better considered prior to study design. In addition, improved reporting quality would facilitate meta-analysis, thereby increasing level of evidence and enabling clinical translation.PMID:35584320 | DOI:10.14309/ctg.0000000000000499
Source: Clinical Colorectal Cancer - May 18, 2022 Category: Cancer & Oncology Authors: Zheng Feng Cary J G Oberije Alouisa J P van de Wetering Alexander Koch Kim A D Wouters Nathalie Vaes Ad A M Masclee Beatriz Carvalho Gerrit A Meijer Maurice P Zeegers James G Herman Veerle Melotte Manon van Engeland Kim M Smits Source Type: research