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Total 81081 results found since Jan 2013.

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
J Nanopart Res. 2023;25(3):43. doi: 10.1007/s11051-023-05690-w. Epub 2023 Feb 27.ABSTRACTRapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this ...
Source: Cell Research - March 6, 2023 Category: Cytology Authors: Reza Abbasi Ghazal Shineh Mohammadmahdi Mobaraki Sarah Doughty Lobat Tayebi Source Type: research

Nanoparticles as an effective drug delivery system in COVID-19
CONCLUSION: Our current studies reveal that nanoparticles may prove very helpful in the delivery of drugs for Covid-19 treatment. Many cases showed that patients, where drugs are delivered with the help of nanoparticles, produced very few side effects.PMID:34649334 | DOI:10.1016/j.biopha.2021.112162
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Neehasri Kumar Chowdhury None Deepika Reshma Choudhury Gaurav Ambadas Sonawane Shankar Mavinamar Xiaoming Lyu Ramendra Pati Pandey Chung-Ming Chang Source Type: research

Summary and analysis of the currently existing literature data on metal-based nanoparticles published for selected aquatic organisms: Applicability for toxicity prediction by (Q)SARs.
Abstract This review establishes an inventory of existing toxicity data on nanoparticles (NPs) with the purpose of developing (Quantitative) Structure-Activity Relationships for NPs (nano-[Q]SARs), and also of maximising the use of scientific sources for NP risk assessment. From a data search carried out on 27 February 2014, a total of 910 publications were retrieved from the Web of Science™ Core Collection, and a database comprising 886 records of toxicity endpoints, based on these publications, was built. The test organisms mainly comprised bacteria, algae, yeast, protozoa, nematoda, crustacea and fish. The NP...
Source: Alternatives to Laboratory Animals : ATLA - September 1, 2015 Category: Research Authors: Chen G, Vijver MG, Peijnenburg WJ Tags: Altern Lab Anim Source Type: research

Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news

A potent virucidal activity of functionalized TiO < sub > 2 < /sub > nanoparticles adsorbed with flavonoids against SARS-CoV-2
Appl Microbiol Biotechnol. 2022 Aug 11:1-16. doi: 10.1007/s00253-022-12112-9. Online ahead of print.ABSTRACTThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of COVID-19 relies on supportive care as no specific targeted therapies are available yet. Given its devastating effects on the economy and mental health, it is imperative to develop novel antivirals. An ideal candidate will be an agent that blocks the early events of viral attachment and cell entry, thereby preventing viral infection and spread. This work reports functionalized...
Source: Applied Microbiology and Biotechnology - August 11, 2022 Category: Microbiology Authors: Gabriela Le ón-Gutiérrez James Edward Elste Carlos Cabello-Guti érrez Cesar Mill án-Pacheco Mario H Mart ínez-Gómez Rafael Mej ía-Alvarez Vaibhav Tiwari Armando Mej ía Source Type: research

Potential of < em > Azadirachta indica < /em > as a Capping Agent for Antiviral Nanoparticles against SARS-CoV-2
Biomed Res Int. 2022 Sep 15;2022:5714035. doi: 10.1155/2022/5714035. eCollection 2022.ABSTRACTA rare type of pneumonia later on referred to as COVID-19 was reported in China in December 2019. Investigations revealed that this disease is caused by a coronavirus previously identified as SARS-CoV-2, and since then, it has become a global pandemic with new strains emerging rapidly as a result of genetic mutations. Various therapeutic options are being explored in order to eradicate this pandemic even though approved vaccine candidates are being currently rolled out globally. Most medicinal plant extracts have astonishing prope...
Source: Biomed Res - September 26, 2022 Category: Research Authors: Frank Eric Tatsing Foka Nanabi Manamela Steven Maluta Mufamadi Hazel Tumelo Mufhandu Source Type: research

Detecting nanoparticles by "listening"
Front Phys (Beijing). 2023;18(5):53602. doi: 10.1007/s11467-023-1287-1. Epub 2023 May 6.ABSTRACTIn the macroscopic world, we can obtain some important information through the vibration of objects, that is, listening to the sound. Likewise, we can also get some information of the nanoparticles that we want to know by the means of "listening" in the microscopic world. In this review, we will introduce two sensing methods (cavity optomechanical sensing and surface-enhanced Raman scattering sensing) which can be used to detect the nanoparticles. The cavity optomechanical systems are mainly used to detect sub-gigahertz nanopart...
Source: Health Physics - May 16, 2023 Category: Physics Authors: Haonan Chang Jun Zhang Source Type: research

A potent virucidal activity of functionalized TiO < sub > 2 < /sub > nanoparticles adsorbed with flavonoids against SARS-CoV-2
Appl Microbiol Biotechnol. 2022 Aug 11. doi: 10.1007/s00253-022-12112-9. Online ahead of print.ABSTRACTThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of COVID-19 relies on supportive care as no specific targeted therapies are available yet. Given its devastating effects on the economy and mental health, it is imperative to develop novel antivirals. An ideal candidate will be an agent that blocks the early events of viral attachment and cell entry, thereby preventing viral infection and spread. This work reports functionalized tita...
Source: Applied Microbiology and Biotechnology - August 11, 2022 Category: Microbiology Authors: Gabriela Le ón-Gutiérrez James Edward Elste Carlos Cabello-Guti érrez Cesar Mill án-Pacheco Mario H Mart ínez-Gómez Rafael Mej ía-Alvarez Vaibhav Tiwari Armando Mej ía Source Type: research

Colorimetric and Raman dual-mode lateral flow immunoassay detection of SARS-CoV-2  N protein antibody based on Ag nanoparticles with ultrathin Au shell assembled onto Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles
In this study, Ag nanoparticles with ultra-thin Au shells embedded with 4-mercaptobenzoic acid (MBA) (AgMBA@Au) were manufactured and then assembled onto Fe3O4 surface by electrostatic interaction to construct the Fe3O4-AgMBA@Au nanoparticles (NPs) with magnetic-Raman-colorimetric properties. Based on the composite nanoparticles, a colorimetric and Raman dual-mode lateral flow immunoassay (LFIA) for ultrasensitive identification of SARS-CoV-2 nucleocapsid (N) protein antibody was constructed. The magnetic nanoparticles (Fe3O4 NPs) were acted as the core and coated a layer of AgMBA@Au particles on the surface by electrostat...
Source: Analytical and Bioanalytical Chemistry - November 22, 2022 Category: Chemistry Authors: Jingwen Li Penghui Liang Tianyu Zhao Gengchen Guo Jinyue Zhu Congying Wen Jingbin Zeng Source Type: research

The detection of IgG class antibodies against SARS-CoV-2 nucleocapsid protein by application of nanoparticles
CONCLUSIONS: Our findings suggest that nanoparticles can be used to improve the sensitivity of ELISA method and increase the detection limit. Thus, it is logical and desirable to enhance the sensitivity of ELISA method by application of nanoparticles; the approach is low cost and with a positive impact on accuracy.PMID:36808369 | DOI:10.26355/eurrev_202302_31227
Source: Pharmacological Reviews - February 22, 2023 Category: Drugs & Pharmacology Authors: S Iordanishvili T Metreveli E Kldiashvili Source Type: research

Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2
Colloids Surf B Biointerfaces. 2021 Mar 26;203:111724. doi: 10.1016/j.colsurfb.2021.111724. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus (COVID-19), is the virus responsible for over 69,613,607 million infections and over 1,582,966 deaths worldwide. All treatment measures and protocols were considered to be supportive only and not curative. During this current coronavirus pandemic, searching for pharmaceutical or traditional complementary and integrative medicine to assist with prevention, treatment, and recovery has been advantageous. These phytop...
Source: Colloids and Surfaces - April 10, 2021 Category: Biotechnology Authors: Gouda H Attia Yasmine S Moemen Mahmoud Youns Ammar M Ibrahim Randa Abdou Mohamed A El Raey Source Type: research