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Nanoparticles as an effective drug delivery system in COVID-19
CONCLUSION: Our current studies reveal that nanoparticles may prove very helpful in the delivery of drugs for Covid-19 treatment. Many cases showed that patients, where drugs are delivered with the help of nanoparticles, produced very few side effects.PMID:34649334 | DOI:10.1016/j.biopha.2021.112162
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Neehasri Kumar Chowdhury None Deepika Reshma Choudhury Gaurav Ambadas Sonawane Shankar Mavinamar Xiaoming Lyu Ramendra Pati Pandey Chung-Ming Chang Source Type: research
Next Phase of NIH Preprint Pilot Launching Soon
Last month, the National Library of Medicine (NLM)announced plans to extend its NIH Preprint Pilot in PubMed Central (PMC) and PubMed beyond COVID-19 to encompass all preprints reporting on NIH-funded research. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award, contract, or intramural program and posted to aneligible preprint server on or after January 1, 2023.In preparation for the launch of this second phase, we have updated PMC and PubMed site features to help users of these databases incorporate the increased volume of preprints into their discovery workflows. S...
Source: PubMed Central News - January 10, 2023 Category: Databases & Libraries Source Type: news
Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news
A potent virucidal activity of functionalized TiO < sub > 2 < /sub > nanoparticles adsorbed with flavonoids against SARS-CoV-2
Appl Microbiol Biotechnol. 2022 Aug 11:1-16. doi: 10.1007/s00253-022-12112-9. Online ahead of print.ABSTRACTThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of COVID-19 relies on supportive care as no specific targeted therapies are available yet. Given its devastating effects on the economy and mental health, it is imperative to develop novel antivirals. An ideal candidate will be an agent that blocks the early events of viral attachment and cell entry, thereby preventing viral infection and spread. This work reports functionalized...
Source: Applied Microbiology and Biotechnology - August 11, 2022 Category: Microbiology Authors: Gabriela Le ón-Gutiérrez James Edward Elste Carlos Cabello-Guti érrez Cesar Mill án-Pacheco Mario H Mart ínez-Gómez Rafael Mej ía-Alvarez Vaibhav Tiwari Armando Mej ía Source Type: research
Potential of < em > Azadirachta indica < /em > as a Capping Agent for Antiviral Nanoparticles against SARS-CoV-2
Biomed Res Int. 2022 Sep 15;2022:5714035. doi: 10.1155/2022/5714035. eCollection 2022.ABSTRACTA rare type of pneumonia later on referred to as COVID-19 was reported in China in December 2019. Investigations revealed that this disease is caused by a coronavirus previously identified as SARS-CoV-2, and since then, it has become a global pandemic with new strains emerging rapidly as a result of genetic mutations. Various therapeutic options are being explored in order to eradicate this pandemic even though approved vaccine candidates are being currently rolled out globally. Most medicinal plant extracts have astonishing prope...
Source: Biomed Res - September 26, 2022 Category: Research Authors: Frank Eric Tatsing Foka Nanabi Manamela Steven Maluta Mufamadi Hazel Tumelo Mufhandu Source Type: research
A potent virucidal activity of functionalized TiO < sub > 2 < /sub > nanoparticles adsorbed with flavonoids against SARS-CoV-2
Appl Microbiol Biotechnol. 2022 Aug 11. doi: 10.1007/s00253-022-12112-9. Online ahead of print.ABSTRACTThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of COVID-19 relies on supportive care as no specific targeted therapies are available yet. Given its devastating effects on the economy and mental health, it is imperative to develop novel antivirals. An ideal candidate will be an agent that blocks the early events of viral attachment and cell entry, thereby preventing viral infection and spread. This work reports functionalized tita...
Source: Applied Microbiology and Biotechnology - August 11, 2022 Category: Microbiology Authors: Gabriela Le ón-Gutiérrez James Edward Elste Carlos Cabello-Guti érrez Cesar Mill án-Pacheco Mario H Mart ínez-Gómez Rafael Mej ía-Alvarez Vaibhav Tiwari Armando Mej ía Source Type: research
Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2
Colloids Surf B Biointerfaces. 2021 Mar 26;203:111724. doi: 10.1016/j.colsurfb.2021.111724. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus (COVID-19), is the virus responsible for over 69,613,607 million infections and over 1,582,966 deaths worldwide. All treatment measures and protocols were considered to be supportive only and not curative. During this current coronavirus pandemic, searching for pharmaceutical or traditional complementary and integrative medicine to assist with prevention, treatment, and recovery has been advantageous. These phytop...
Source: Colloids and Surfaces - April 10, 2021 Category: Biotechnology Authors: Gouda H Attia Yasmine S Moemen Mahmoud Youns Ammar M Ibrahim Randa Abdou Mohamed A El Raey Source Type: research
Synthesis of bee venom loaded chitosan nanoparticles for anti-MERS-COV and multi-drug resistance bacteria
This study aims to fully exploit the natural compound; bee venom (BV) as a substance that can kill and inhibit the growth of microbes and viruses. For this target, BV was loaded onto a safe, natural, and economically inexpensive polymer, which is chitosan (Ch) in its nano-size form using the ionic gelation method and chemical crosslinking agent (sodium tripolyphosphate; TPP). The findings illustrated that chitosan nanoparticles (ChNPs) were prepared thru this method exhibited spherical shape and average hydrodynamic size of 202 nm with a polydispersity index (PDI = 0.44). However, the size was increased to 221 nm and PDI (...
Source: International Journal of Biological Macromolecules - October 25, 2022 Category: Biochemistry Authors: Mohamed E Elnosary Hesham A Aboelmagd Manal A Habaka Salem R Salem Mehrez E El-Naggar Source Type: research
Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus.
In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS. Although both types of vaccine could induce specific immunoglobulin G against MERS-CoV, neutralizing antibodies against MERS-CoV we...
Source: Vaccine - May 5, 2018 Category: Allergy & Immunology Authors: Jung SY, Kang KW, Lee EY, Seo DW, Kim HL, Kim H, Kwon T, Park HL, Kim H, Lee SM, Nam JH Tags: Vaccine Source Type: research
Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2
Colloids Surf B Biointerfaces. 2021 Mar 26;203:111724. doi: 10.1016/j.colsurfb.2021.111724. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus (COVID-19), is the virus responsible for over 69,613,607 million infections and over 1,582,966 deaths worldwide. All treatment measures and protocols were considered to be supportive only and not curative. During this current coronavirus pandemic, searching for pharmaceutical or traditional complementary and integrative medicine to assist with prevention, treatment, and recovery has been advantageous. These phytop...
Source: Colloids and Surfaces - April 10, 2021 Category: Biotechnology Authors: Gouda H Attia Yasmine S Moemen Mahmoud Youns Ammar M Ibrahim Randa Abdou Mohamed A El Raey Source Type: research
Preparation of cellulose based wipes treated with antimicrobial and antiviral silver nanoparticles as novel effective high-performance coronavirus fighter
Int J Biol Macromol. 2021 Apr 14:S0141-8130(21)00830-8. doi: 10.1016/j.ijbiomac.2021.04.071. Online ahead of print.ABSTRACTCoronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). We successful to prepare disinfectant cellulose-based wipes treated with antimicrobial and antiviral silver nanoparticles to be used for prevention of contamination and transmission of several pathogenic viruses and microbes to human in critical areas such as hospitals and healthcar...
Source: International Journal of Biological Macromolecules - April 17, 2021 Category: Biochemistry Authors: Tamer Hamouda Hassan M Ibrahim H H Kafafy H M Mashaly Nasser H Mohamed Nermin M Aly Source Type: research
Design and application of nanoparticles as vaccine adjuvants against human corona virus infection
J Inorg Biochem. 2021 Mar 29;219:111454. doi: 10.1016/j.jinorgbio.2021.111454. Online ahead of print.ABSTRACTIn recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and modulating immunity. Adjuvants have an unshakable position in the battle against the virus. In addition to the perennial use of aluminium adjuvant, nanoparticles have become the developing adjuvant candidates due to their unique properties. Here we introduce several typical nanop...
Source: Journal of Inorganic Biochemistry - April 20, 2021 Category: Biochemistry Authors: Lichun Mao Ziwei Chen Yaling Wang Chunying Chen Source Type: research
