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Spray-dried tenofovir alafenamide-chitosan nanoparticles loaded oleogels as a long-acting injectable depot system of anti-HIV drug
Int J Biol Macromol. 2022 Sep 19;222(Pt A):473-486. doi: 10.1016/j.ijbiomac.2022.09.164. Online ahead of print.ABSTRACTThe development of suitable drug delivery systems for prolonged action against HIV receives great attention in recent research. Herein, a long-acting injectable (LAI) of Tenofovir alafenamide-chitosan polymeric nanoparticles loaded oleogels developed with sesame oil and ethyl cellulose for prolonged release of the drug is reported for the first time. The research resulted with unique long-acting parenteral formulation for chronic anti-retroviral therapy, based on our experimental in-vitro and ex-vivo studi...
Source: International Journal of Biological Macromolecules - October 3, 2022 Category: Biochemistry Authors: Vedha Hari B Narayanan Artur Lewandowski Ramyadevi Durai Weronika Gonciarz Pawe ł Wawrzyniak Marek Brzezinski Source Type: research
Recent Trends of Biocompatible and Biodegradable Nanoparticles in Drug Delivery: A Review.
This article focuses on the properties such as biocompatibility and biodegradability, which are considered as essential criteria for nanoparticles to be successfully used as a carrier molecule in drug delivery systems. Physicochemical characterization of the nanoparticles such as size and size distribution, surface morphology, zeta potential and surface chemistry has a significant role in the successful formulation and applications in drug delivery systems. Mostly, the size and surface characteristics of nanoparticles enable enhanced intracellular accumulation in tumor cells through passive targeting mechanisms and rapid d...
Source: Current Medicinal Chemistry - June 5, 2016 Category: Chemistry Authors: Sundar DS, Antoniraj MG, Kumar CS, Mohapatra SS, Houreld NN, Ruckmani K Tags: Curr Med Chem Source Type: research
Tenofovir alafenamide and elvitegravir loaded nanoparticles for long-acting prevention of HIV-1 vaginal transmission
Conclusion: This proof-of-concept study demonstrated sustained protection for TAF + EVG nanoparticles in a hu-BLT mouse model of HIV vaginal transmission.
Source: AIDS - January 28, 2017 Category: Infectious Diseases Tags: Basic Science Source Type: research
Gelatin modified lipid nanoparticles for anti retroviral drug delivery.
Abstract
The major challenges to clinical application of zidovudine are its moderate aqueous solubility and relative short half-life and serious side effects due to frequent administrations. We investigated the preparation of zidovudine-loaded nanoparticles based on lipids which were further modified with the polymer gelatin. Formulation and stability of the modified nanoparticles were analysed from the physico-chemical characterizations. The interactions of nanoparticles with blood components were tested by hemolysis and aggregation studies. The drug content and entrapment efficiencies were assessed by UV analysi...
Source: Chemistry and Physics of Lipids - July 8, 2017 Category: Lipidology Authors: K S J, S S, Kalarikkal N, Pothen LA, Thomas S Tags: Chem Phys Lipids Source Type: research
Gelatin modified lipid nanoparticles for anti- viral drug delivery.
Abstract
The major challenges to clinical application of zidovudine are its moderate aqueous solubility and relative short half-life and serious side effects due to frequent administrations. We investigated the preparation of zidovudine-loaded nanoparticles based on lipids which were further modified with the polymer gelatin. Formulation and stability of the modified nanoparticles were analysed from the physico-chemical characterizations. The interactions of nanoparticles with blood components were tested by haemolysis and aggregation studies. The drug content and entrapment efficiencies were assessed by UV analys...
Source: Chemistry and Physics of Lipids - September 27, 2017 Category: Lipidology Authors: K S J, S S, Kalarikkal N, Pothen LA, Thomas S Tags: Chem Phys Lipids Source Type: research
Cytotoxicity, genotoxicity, transplacental transfer and tissue disposition in pregnant rats mediated by nanoparticles: the case of magnetic core mesoporous silica nanoparticles.
In this study we performed mutagenicity, cytotoxic and transplacental evaluation of magnetic core mesoporous silica nanoparticles, radiolabeled with 99mTc for determination of toxicogenic and embryonic/fetuses potential risk in animal model. Magnetic core mesoporous silica nanoparticles were produced and characterized by obtaining nanoparticles with a size of (58.9 ± 8.1 nm) in spherical shape and with intact magnetic core. The 99 m Tc radiolabeling process demonstrated high efficacy and stability in 98% yield over a period of 8 hours of stability. Mutagenicity assays were performed using Salmonella enteric sero...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 25, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
pH-Triggered polymeric Nanoparticles-in-Gel for Preventing Vaginal Transmission of HIV and Unintended Pregnancy
Eur J Pharm Biopharm. 2023 Sep 3:S0939-6411(23)00234-5. doi: 10.1016/j.ejpb.2023.09.001. Online ahead of print.ABSTRACTHuman Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/ AIDS) and unplanned pregnancy affect female reproductive health globally. A single product providing a dual purpose of contraception and HIV prophylaxis may improve adherence to the therapy. Thus, we formulated a female-centric multipurpose prevention technology (MPT) comprising of nanoparticle loaded vaginal gel formulation acting as a contraceptive and microbicide. Eudragit® S100 nanoparticles of Atazanavir sulphate (ATZ; antiviral) a...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 5, 2023 Category: Drugs & Pharmacology Authors: Trinette Fernandes Vainav Patel Clara Aranha Shilpa Velhal Munira Momin Madhura Mulkutkar Sujata Sawarkar Source Type: research
Preparation of β-D glucan nanoparticles and its antifungal activity.
Abstract
This work demonstrates the preparation of β-D-glucan (isolated from the cell wall of Pythium aphanidermatum) nanoparticles through the addition of 2% (w/v) sodium hydroxide to β-D glucan solution with constant stirring at 90° C. Addition of sodium tripolyphosphate (TPP) aids the stable formation of nanoparticles. Fourier transform infrared (FTIR) spectroscopy confirmed phosphoric groups of TPP linked with OH group of β-D-glucan in the nanoparticles. The formation of nanoparticles was observed by the peak at 386nm using UV- visible spectroscopy. The average size of nanoparticle as determined by Zetasiz...
Source: International Journal of Biological Macromolecules - July 15, 2014 Category: Biochemistry Authors: Anusuya S, Sathiyabama M Tags: Int J Biol Macromol Source Type: research
Evaluation of the reproductive toxicity of antiretroviral drug loaded lactoferrin nanoparticles.
Abstract
Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating anticancer or antiretroviral drugs are found to be promising agents to specifically deliver drugs at the target sites. Recent studies indicate that the bioavailability is higher for antiretroviral drugs delivered by LFNPs than when the drugs are administered alone. Although LFNP-mediated drug d...
Source: Systems Biology in Reproductive Medicine - September 27, 2018 Category: Reproduction Medicine Authors: Madugulla L, Ravula AR, Kondapi AK, Yenugu S Tags: Syst Biol Reprod Med Source Type: research
Nanoparticles Containing Cyclodextrins to Sequester Cholesterol Do Well in an Atherosclerosis Animal Model
Cyclodextrins bind to cholesterol. This aspect of their biochemistry has been used by the Underdog Pharmaceuticals team to produce a cyclodextrin that binds the form of toxic oxidized cholesterol known as 7-ketocholesterol. 7-ketocholesterol builds up with age and is implicated in a range of age-related conditions, particularly atherosclerosis, as altered cholesterols cause dysfunction in the macrophage cells responsible for removing cholesterols and other lipids from blood vessel walls. The outcome is the creation of fatty lesions that narrow and weaken blood vessels in older individuals, an ultimately fatal condition. Re...
Source: Fight Aging! - June 24, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Self-fluorescence property of octa-arginine functionalized hydroxyapatite nanoparticles aids in studying their intracellular fate in R1 ESCs
Biochem Biophys Res Commun. 2022 Aug 9;627:21-29. doi: 10.1016/j.bbrc.2022.08.012. Online ahead of print.ABSTRACTDeciphering the endocytosis mechanisms of nanoparticle entry in cells is crucial to understand the fate of nanoparticles and the biological activity of the transported cargo. Such studies require the use of reporter agents such as fluorescent markers. Previously, we have reported the synthesis of self-fluorescent HAp nanoparticles as efficient nucleic acid delivery agents in prokaryotic and eukaryotic cells. Here, we show the application of biocompatible self-fluorescent nano delivery vehicle based on HAp and CP...
Source: Biochemical and Biophysical Research communications - August 27, 2022 Category: Biochemistry Authors: Pranjita Zantye Indrani Talukdar Sutapa Roy Ramanan Meenal Kowshik Source Type: research
Self-Assembled Ferritin Nanoparticles Expressing Hemagglutinin as an Influenza Vaccine
NIH inventors at the Vaccine Research Center have developed a novel influenza virus hemagglutinin (HA)-ferritin nanoparticle influenza vaccine that is easily manufactured, potent, and elicits broadly neutralizing influenza antibodies against multiple strains of influenza. This novel influenza nanoparticle vaccine elicited two types of broadly neutralizing, cross-protective antibodies, one directed to the highly conserved HA stem and a second proximal to the conserved receptor binding site (RBS) of the viral HA, providing a new platform for universal and seasonal influenza. In addition, HA-ferritin nanoparticles can be easi...
Source: NIH OTT Licensing Opportunities - July 20, 2012 Category: Research Authors: admin Source Type: research
Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the intestinal solubilisation of a lipophilic weak base.
Abstract
A novel hybrid microparticulate system composed of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and submicron medium-chain triglyceride (MCT) droplets was fabricated to overcome the pH-dependent solubility and precipitation challenges associated with a model poorly water-soluble weak base, cinnarizine (CIN). Molecular CIN was confined within both the lipid and polymer phase of PLGA-lipid hybrid (PLH) and PLGA-lipid-mannitol hybrid (PLMH) particles, which offered significant biopharmaceutical advantages in comparison to the unformulated drug, submicron MCT droplets and PLGA nanoparticles. This was hi...
Source: European Journal of Pharmaceutical Sciences - March 17, 2018 Category: Drugs & Pharmacology Authors: Joyce P, Prestidge CA Tags: Eur J Pharm Sci Source Type: research
