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Nanoparticles On My Mind
By KIM BELLARD Nanoparticles are everywhere!  By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare.   But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger. Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants.  They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs

The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions.
Abstract The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, ra...
Source: Diabetes Care - November 25, 2014 Category: Endocrinology Authors: Hamman RF, Bell RA, Dabelea D, D'Agostino RB, Dolan L, Imperatore G, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Pihoker C, Rodriguez BL, Saydah S, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Sara—the Search and Rescue Dog—and her Game of Fetch
Editor’s note: Jana Sweeny is the American Red Cross’s Director of International Communications. She and her team are traveling around Colombia this week, visiting communities made safer by the Red Cross.   As we walk into the Colombian Red Cross training center in Pereira, a yellow lab comes bouncing up, waving her tail enthusiastically. The ball in her mouth turns out to be a lime and she is ready to play fetch. Because I can never say no to a dog, I begin a game of “fetch the lime” with her. It turns out that Sara isn’t just a fun companion–she is a retired search and rescue dog.  The Colo...
Source: Red Cross Chat - January 24, 2014 Category: Global & Universal Authors: Jenelle Eli Tags: International Preparedness colombia dogs pets Search and Rescue South America Source Type: news

Next Phase of NIH Preprint Pilot Launching Soon
Last month, the National Library of Medicine (NLM)announced plans to extend its NIH Preprint Pilot in PubMed Central (PMC) and PubMed beyond COVID-19 to encompass all preprints reporting on NIH-funded research. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award, contract, or intramural program and posted to aneligible preprint server on or after January 1, 2023.In preparation for the launch of this second phase, we have updated PMC and PubMed site features to help users of these databases incorporate the increased volume of preprints into their discovery workflows. S...
Source: PubMed Central News - January 10, 2023 Category: Databases & Libraries Source Type: news

Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news

Peas in a Pod? The Similarities between UFPs and Nanoparticles Yield Research Opportunities
PDF Version (514 KB) About This Article Published: 20 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Nanomaterials Versus Ambient Ultrafine Particles: An Oppor...
Source: EHP Research - October 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Bio-nanotechnological advancement of orally administered insulin nanoparticles: Comprehensive review of experimental design for physicochemical characterization
Publication date: Available online 9 November 2019Source: International Journal of PharmaceuticsAuthor(s): Chun Y. Wong, Giuseppe Luna, Jorge Martinez, Hani Al-Salami, Crispin R. DassAbstractTherapeutic proteins are labile macromolecules that are prone to degradation during production, freeze-drying and storage. Recent studies showed that nanoparticles can enhance the stability and oral bioavailability of encapsulated proteins. Several conventional approaches (enzyme inhibitors, mucoadhesive polymers) and novel strategies (surface modification, ligand conjugation, flash nano-complexation, stimuli-responsive drug delivery s...
Source: International Journal of Pharmaceutics - November 10, 2019 Category: Drugs & Pharmacology Source Type: research

Molecular imaging with nanoparticles: the dwarf actors revisited 10  years later
AbstractWe explore present-day trends and challenges in nanomedicine. Creativity in the laboratories continues: the published literature on novel nanoparticles is now vast. Nanoagents are discussed here which are composed entirely of strongly photoluminescent materials, tunable to desired optical properties and of inherently low toxicity. We focus on “quantum nanoparticles” prepared from allotropes of carbon. The principles behind strong, tunable photoluminescence are quantum mechanical: we present them in simple outline. The major industries racing to develop these materials can offer significant technical guidance to...
Source: Histochemistry and Cell Biology - November 16, 2018 Category: Biomedical Science Source Type: research

Office of Postsecondary Education (OPE): Talent Search Program CFDA Number 84.044A
Funding Opportunity Number: ED-GRANTS-122215-001 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: EducationCFDA Number: 84.044Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Native American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofit...
Source: Grants.gov - December 23, 2015 Category: Research Tags: Education Source Type: funding

Innovation search dynamics in new domains: An exploratory study of academic founders' search for funding in the biotechnology industry
Publication date: Available online 15 January 2017 Source:Technological Forecasting and Social Change Author(s): Susan K. Cohen, Natasha V. Munshi Previous studies have emphasized the role of experience in shaping the mental models and theories that guide search, but offered minimal insight into how individuals navigate domains for which their experience provides no problem-relevant schemata. To explore how search unfolds in such new domains (ND), we study first time academic founders' quest for early-stage funding, a critical step in the innovation process. We observe that these founders differentially recombine institut...
Source: Technological Forecasting and Social Change - January 14, 2017 Category: Science Source Type: research

UCLA researchers' smartphone 'microscope' can detect a single virus, nanoparticles
Your smartphone now can see what the naked eye cannot: A single virus and bits of material less than one-thousandth of the width of a human hair.   Aydogan Ozcan, a professor of electrical engineering and bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science, and his team have created a portable smartphone attachment that can be used to perform sophisticated field testing to detect viruses and bacteria without the need for bulky and expensive microscopes and lab equipment. The device weighs less than half a pound.   "This cellphone-based imaging platform could be used for specific and...
Source: UCLA Newsroom: Health Sciences - September 16, 2013 Category: Universities & Medical Training Source Type: news

Diagnostic and Therapeutic Nanoparticles in Cardiovascular Diseases.
Abstract Cardiovascular diseases are the major cause of non-communicable illness in both developing and developed nations, representing 30% of global deaths. New therapeutic approaches are desperately needed. Nanomedicine represents one such approach, and involves using molecular entities on the scale of 10-150 nanometers, for purposes of diagnosing, treating, and preventing disease. This review provides a basic overview of nanotechnology, then reviews specific applications of nanotechnology to cardiovascular diseases. Most research has focused on diagnosing and treating atherosclerosis using nanoparticles (NPs). ...
Source: Current Pharmaceutical Design - October 27, 2015 Category: Drugs & Pharmacology Authors: Tyler PD, Kang PM Tags: Curr Pharm Des Source Type: research

Search and Rescue peer-to-peer opioids prescriber education campaign
Funding Opportunity ID: 292013 Opportunity Number: RFA-FD-17-008 Opportunity Title: Search and Rescue peer-to-peer opioids prescriber education campaignOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: AgricultureConsumer ProtectionFood and NutritionCategory Explanation: CFDA Number(s): 93.103Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: The following organization is eligible to apply: The Partnership for Drug Free Ki...
Source: Grants.gov - February 23, 2017 Category: Research Tags: Agriculture Consumer Protection Food and Nutrition Source Type: funding

Overcoming Drug Resistance in Myeloma By Synchronized Delivery of Therapeutic and Bone Marrow Disrupting Agents By Nanoparticles Targeting Tumor-Associated Endothelium
This study provides the preclinical basis for future clinical trials using MM-BMM-targeted nanomedicine able to enhance the effect of PIs or other drugs for the treatment of MM.DisclosuresRoccaro: GILEAD: Research Funding; AMGEN: Other: Advisory Board. Vij: Karyopharma: Honoraria, Membership on an entity's Board of Directors or advisory committees; Jansson: Honoraria, Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or adv...
Source: Blood - November 21, 2018 Category: Hematology Authors: Federico, C., Muz, B., Sun, J., Alhallak, K., King, J., Kohnen, D. R., Fiala, M. A., Roccaro, A. M., Vij, R., Azab, A. K. Tags: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Poster I Source Type: research

Development of Acute Myeloid Leukemia Cell Membrane Coated Nanoparticles (AMCNPs) for Cancer Vaccination Immunotherapy
Acute Myeloid Leukemia (AML) is the most common acute leukemia in adults and has a five-year survival rate under 50%. Most patients will relapse even after complete remission is achieved through standard chemotherapy. Thus, one barrier in current AML therapy is how to target the minimal residual disease during remission. Recent developments in understanding cancer cell antigen presentation and immunosuppression have revealed the promise of cancer immunotherapy in activating immune responses to target residual disease. Each leukemia patient has a unique spectrum of cell surface antigens, which are mostly uncharacterized. If...
Source: Blood - November 21, 2018 Category: Hematology Authors: Johnson, D. T., Kroll, A. V., Fang, R. H., Kline, J., Zhang, L., Zhang, D.-E. Tags: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster III Source Type: research