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Mitochondrial Toxicity of Cadmium Telluride Quantum Dot Nanoparticles in Mammalian Hepatocytes
There are an increasing number of studies indicating that mitochondria are relevant targets in nanomaterial-induced toxicity. However, the underlying mechanisms by which nanoparticles (NPs) interact with these organelles and affect their functions are unknown. The aim of this study was to investigate the effects of cadmium telluride quantum dot (CdTe-QD) NPs on mitochondria in human hepatocellular carcinoma HepG2 cells. CdTe-QD treatment resulted in the enlargement of mitochondria as examined with transmission electron microscopy and confocal microscopy. CdTe-QDs appeared to associate with the isolated mitochondria as dete...
Source: Toxicological Sciences - June 22, 2015 Category: Toxicology Authors: Nguyen, K. C., Rippstein, P., Tayabali, A. F., Willmore, W. G. Tags: Quantum Dot Nanoparticles and Mitochondrial Function Source Type: research
Injectable calcium phosphate scaffold with iron oxide nanoparticles to enhance osteogenesis via dental pulp stem cells.
In conclusion, it is highly promising to incorporate γIONPs and αIONPs into CPC scaffold for bone tissue engineering, yielding substantially better stem cell attachment, spreading and osteogenic differentiation, and much greater bone mineral synthesis by the seeded cells. Therefore, novel CPC scaffolds containing γIONPs and αIONPs are promising for dental, craniofacial and orthopaedic applications to substantially enhance bone regeneration.
PMID: 29355052 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 24, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field
Colloids Surf B Biointerfaces. 2021 Jun 18;206:111931. doi: 10.1016/j.colsurfb.2021.111931. Online ahead of print.ABSTRACTThis work is devoted to studying the effects of non-magnetic shell coating on nanoparticles in a low frequency alternating magnetic field (LF AMF) on tumor cells in vitro. Two types of iron oxide nanoparticles with the same magnetic core with and without silica shells were synthesized. Nanoparticles with silica shells significantly decreased the viability of PC3 cancer cells in a low frequency alternating magnetic field according to the cytotoxicity test, unlike uncoated nanoparticles. We showed that ce...
Source: Colloids and Surfaces - June 25, 2021 Category: Biotechnology Authors: A R Iliasov T R Nizamov V A Naumenko A S Garanina S S Vodopyanov A A Nikitin A G Pershina A A Chernysheva Y Kan P S Mogilnikov O N Metelkina I V Schetinin A G Savchenko A G Majouga M A Abakumov Source Type: research
Mint leaves (Mentha arvensis) mediated CaO nanoparticles in dye degradation and their role in anti-inflammatory, anti-cancer properties
Environ Res. 2023 Jul 20:116718. doi: 10.1016/j.envres.2023.116718. Online ahead of print.ABSTRACTIn ancient times, herbal plants were considered one of the greatest gifts from nature that human beings could receive, and about 80% of these plants have medicinal uses. In traditional medicine, Mentha arvensis, commonly known as mint, has many applications, and in the present study, the mint leaf extract has been used to synthesis nanoparticles using the mint leaf extract as a biosource for the extraction of nanoparticles. In addition to having a wide range of applications in various fields, calcium oxide (CaO) nanoparticles ...
Source: Environmental Research - July 22, 2023 Category: Environmental Health Authors: Rajasree Shanmuganathan Quynh Hoang Le Sandhanasamy Devanesan Shaban R M Sayed V Devi Rajeswari Xinghui Liu G K Jhanani Source Type: research
Silica-coated calcium phosphate nanoparticles for gene silencing of NF- κB p65 by siRNA and their impact on cellular players of inflammation
Biomaterials. 2021 Jul 7;276:121013. doi: 10.1016/j.biomaterials.2021.121013. Online ahead of print.ABSTRACTThe transcription factor NF-κB and its signaling cascade both play key roles in all inflammatory processes. The most critical member of the NF-κB transcription factor family is p65. We investigated the role of cationic silica-coated calcium phosphate nanoparticles (spherical, diameter by SEM 50-60 nm; zeta potential about +26 mV; stabilized by polyethyleneimine) carrying encapsulated siRNA against NF-κB p65 and their influence on inflamed cells. The nanoparticles were taken up by cells of the blood compartment inv...
Source: Biomaterials - July 12, 2021 Category: Materials Science Authors: Nataniel Bia łas Elena K M üller Matthias Epple Ingrid Hilger Source Type: research
Calcium phosphate adjuvanted nanoparticles of outer membrane proteins of < em > Salmonella < /em > Typhi as a candidate for vaccine development against Typhoid fever
Conclusion. Calcium phosphate nanoparticles as adjuvant in vaccines is safe, have good encapsulation and loading capacity and induce a strong cell mediated, humoral and protective immune response.PMID:35476604 | DOI:10.1099/jmm.0.001529
Source: Journal of Medical Microbiology - April 27, 2022 Category: Microbiology Authors: Yashpal Singh Anjani Saxena S P Singh Manish Kumar Verma Arun Kumar Avadhesh Kumar Meena Mrigesh Mumtesh Kumar Saxena Source Type: research
