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Recent applications of click chemistry for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles
Abstract
Glycoscience, despite its myriad of challenges, promises to unravel the causes of, potential new detection methods for, and novel therapeutic strategies against, many disease states. In the last two decades, glyco-gold nanoparticles have emerged as one of several potential new tools for glycoscientists. Glyco-gold nanoparticles consist of the unique structural combination of a gold nanoparticle core and an outer-shell comprising multivalent presentation of carbohydrates. The combination of the distinctive physicochemical properties of the gold core and the biological function/activity of the carbohydrates makes gl...
Source: Beilstein Journal of Organic Chemistry - January 3, 2018 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: azide – alkyne Huisgen cycloaddition carbohydrates click chemistry glyco-gold nanoparticles triazole Review Source Type: research
Exploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms – from in vitro to ex vitro testing
Publication date: Available online 22 August 2018Source: Carbohydrate PolymersAuthor(s): Eduardo M. Costa, Sara Silva, Mariana Veiga, Freni K. Tavaria, Maria M. PintadoAbstractNowadays, nosocomial skin infections are increasingly harder to manage and control. In the search for new, natural compounds capable of being alternatives to traditional antibiotics, chitosan and its nanoparticles, have garnered attention. This work sought to understand the potential of chitosan NPs in the management of infections caused by MDR skin pathogens in planktonic and sessile assays. Additionally, NPs’ capacity to inhibit biofilm quorum se...
Source: Carbohydrate Polymers - August 23, 2018 Category: Biomedical Science Source Type: research
Untargeted analysis of pure snail slime and snail slime ‐induced Au nanoparticles (AuNPs) metabolome with MALDI FT‐ICR MS
AbstractChronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. TheHelix Aspersa snail slime ‐based products are increasingly being used for skin injury, thanks to their ability to make tissue repair processes faster. To date, a comprehensive overview of pure snail slime metabolome is not available. Besides, Au nanoparti...
Source: Journal of Mass Spectrometry - March 15, 2021 Category: Chemistry Authors: Alberto Onzo,
Raffaella Pascale,
Maria Assunta Acquavia,
Pinalysa Cosma,
Jennifer Gubitosa,
Carmine Gaeta,
Patrizia Iannece,
Yuri Tsybin,
Vito Rizzi,
Antonio Guerrieri,
Rosanna Ciriello,
Giuliana Bianco Tags: RESEARCH ARTICLE Source Type: research
Untargeted analysis of pure snail slime and snail slime ‐induced Au nanoparticles metabolome with MALDI FT‐ICR MS
AbstractChronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. TheHelix aspersa snail slime ‐based products are increasingly being used for skin injury, thanks to their ability to make tissue repair processes faster. To date, a comprehensive overview of pure snail slime metabolome is not available. Besides, Au nanoparti...
Source: Journal of Mass Spectrometry - April 5, 2021 Category: Chemistry Authors: Alberto Onzo,
Raffaella Pascale,
Maria Assunta Acquavia,
Pinalysa Cosma,
Jennifer Gubitosa,
Carmine Gaeta,
Patrizia Iannece,
Yuri Tsybin,
Vito Rizzi,
Antonio Guerrieri,
Rosanna Ciriello,
Giuliana Bianco Tags: RESEARCH ARTICLE Source Type: research
Toxicological effects of selenium nanoparticles in laboratory animals: A review
AbstractThis paper provides a comprehensive summary of the main toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals, up until February 28, 2023. A literature search revealed 17 articles describing experimental studies conducted on warm-blooded animals. Despite some uncertainties, in vivo studies have demonstrated that selenium NPs have an adverse effect on laboratory animals, as evidenced by several indicators of general toxic action. These effects include reductions of body mass, changes in hepatotoxicity indices (increased enzyme activity and accumulation of selenium in the liver), an...
Source: Journal of Applied Toxicology - June 14, 2023 Category: Toxicology Authors: Yuliya V. Ryabova,
Marina P. Sutunkova,
Ilzira A. Minigalieva,
Lada V. Shabardina,
Tommaso Filippini,
Aristides Tsatsakis Tags: REVIEW ARTICLE Source Type: research
Phytofabrication of Selenium Nanoparticles From Emblica officinalis Fruit Extract and Exploring Its Biopotential Applications: Antioxidant, Antimicrobial, and Biocompatibility
Conclusion
The present study shows phytofabrication of SeNPs from aqueous fruit extract of E. officinalis by facile, green, economic, and eco-friendly approach. The aqueous fruit extract of E. officinalis was rich with phenolics, flavonoids, and tannins, and was found appropriate for biosynthesis of nanoparticles. The synthesized PF-SeNPs exhibited highly stable, negative charge, amorphous nature, spherical shape and nano-size. The PF-SeNPs has presented efficient bio-potential applications, i.e., antioxidant, antimicrobial, and biocompatibility. The PF-SeNPs has shown potent free radical scavenging activity and it was fo...
Source: Frontiers in Microbiology - April 29, 2019 Category: Microbiology Source Type: research
Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes
This study has explored seven different approaches for the immobilization of poly(lactic acid) (PLA) nanoparticles on the surface of two different T lymphocyte cell lines. The cell lines used were human Jurkat T cells and CD4+ TEM cells. The latter cells possess blood-brain barrier (BBB) migratory properties and are attractive for the development of cell-based delivery systems to the central nervous system (CNS). PLA nanoparticles were immobilized either via covalent active ester-amine, azide-alkyne cycloaddition, and thiol-maleimide coupling, or via noncovalent approaches that use lectin-carbohydrate, electrostatic, or bi...
Source: Biomacromolecules - June 25, 2021 Category: Biochemistry Authors: Tanja Thomsen Regina Reissmann Elisa Kaba Britta Engelhardt Harm-Anton Klok Source Type: research
Gold Nanoparticles Supported on Ceria Nanoparticles Modulate Leukocyte-Endothelium Cell Interactions and Inflammation in Type 2 Diabetes
Antioxidants (Basel). 2022 Nov 20;11(11):2297. doi: 10.3390/antiox11112297.ABSTRACTGold-ceria nanoparticles (Au/CeO2) are known to have antioxidant properties. However, whether these nanoparticles can provide benefits in type 2 diabetes mellitus (T2D) remains unknown. This work aimed to study the effects of Au/CeO2 nanoparticles at different rates of gold purity (10, 4.4, 1.79 and 0.82) on leukocyte-endothelium interactions and inflammation in T2D patients. Anthropometric and metabolic parameters, leukocyte-endothelium interactions, ROS production and NF-κB expression were assessed in 57 T2D patients and 51 healthy subjec...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Pedro D íaz-Pozo Francisco Canet Abdessamad Grirrane Sandra Lopez-Domenech Jos é Raul Herance Nadezda Apostolova Clara Luna-Marco Susana Rovira-Llopis Miguel Marti Carlos Morillas Milagros Rocha Hermenegildo Garcia Victor M Victor Source Type: research
