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Track analysis of a synchrotron X-ray photoelectric nanoradiator by in situ fluorescence imaging of reactive oxygen species: comparative study of gold and iron oxide nanoparticles
The emission of fluorescent X-rays and low-energy electrons by mid-/high-Z nanoparticles upon irradiation with either X-ray photons or high-energy ion beams is referred to as the nanoradiator effect (NRE). A track analysis of NRE was performed using reactive oxygen species (ROS) gels, to which macrophages containing gold nanoparticles (AuNPs) were attached, together with single-cell irradiation of the intracellular nanoparticles from a microbeam of synchrotron X-rays, and the range and distribution of ^\bulletOH and O2^{ \bullet - } produced were compared with those of the Fe-nanoradiator by magnetite nanoparticles (FeONP,...
Source: Journal of Synchrotron Radiation - September 20, 2018 Category: Physics Authors: Jeon, J.-K. Kim, J.-K. Tags: X-ray photoelectric nanoradiator ROS-oxidant fluorescence gel dosimetry track analysis gold nanoparticles iron oxide nanoparticle research papers Source Type: research

Signature of antiphase boundaries in iron oxide nanoparticles
Iron oxide nanoparticles find a wide variety of applications, including targeted drug delivery and hyperthermia in advanced cancer treatment methods. An important property of these particles is their maximum net magnetization, which has been repeatedly reported to be drastically lower than the bulk reference value. Previous studies have shown that planar lattice defects known as antiphase boundaries (APBs) have an important influence on the particle magnetization. The influence of APBs on the atomic spin structure of nanoparticles with the γ -Fe2O3 composition is examined via Monte Carlo simulations, explicitly considerin...
Source: Journal of Applied Crystallography - November 16, 2021 Category: Physics Authors: K ö hler, T. Feoktystov, A. Petracic, O. Nandakumaran, N. Cervellino, A. Br ü ckel, T. Tags: nanoparticles X-ray powder diffraction Monte Carlo simulations Debye scattering equation antiphase boundaries research papers Source Type: research

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke
as Endres, Ulrich Dirnagl & Tracy D Farr
Source: Journal of Cerebral Blood Flow - February 27, 2013 Category: Neurology Authors: Christoph HarmsAnna Lena DatwylerFrank WiekhorstLutz TrahmsRandall LindquistEyk SchellenbergerSusanne MuellerGunnar SchützFarnoosh RoohiAndreas IdeMartina FüchtemeierKaren GertzGolo KronenbergUlrike HarmsMatthias EndresUlrich DirnaglTracy D Farr Tags: inflammation iron oxide nanoparticles magnetic resonance imaging stroke Source Type: research

SAXS analysis of single- and multi-core iron oxide magnetic nanoparticles
This article reports on the characterization of four superparamagnetic iron oxide nanoparticles stabilized with dimercaptosuccinic acid, which are suitable candidates for reference materials for magnetic properties. Particles p1 and p2 are single-core particles, while p3 and p4 are multi-core particles. Small-angle X-ray scattering analysis reveals a lognormal type of size distribution for the iron oxide cores of the particles. Their mean radii are 6.9   nm (p1), 10.6   nm (p2), 5.5   nm (p3) and 4.1   nm (p4), with narrow relative distribution widths of 0.08, 0.13, 0.08 and 0.12. The cores are arranged as a cluste...
Source: Journal of Applied Crystallography - March 13, 2017 Category: Physics Authors: Szczerba, W. Costo, R. Veintemillas-Verdaguer, S. Morales, M. del P. Th ü nemann, A.F. Tags: superparamagnetic nanoparticles iron oxide reference materials SAXS small-angle X-ray scattering XANES X-ray absorption near-edge structure X-ray absorption fine structure research papers Source Type: research

Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia
This study is the first to describe nanoparticles that enable systemically delivered magnetic hyperthermia for endometriosis treatment. When subjected to an alternating magnetic field (AMF), these hexagonal iron-oxide nanoparticles exhibit extraordina ry heating efficiency that is 6.4× greater than their spherical counterparts. Modifying nanoparticles with a peptide targeted to vascular endothelial growth factor receptor 2 (VEGFR-2) enhances their endometriosis specificity. Studies in mice bearing transplants of macaque endometriotic tissue reve al that, following intravenous injection at a low dose (3 mg per kg), these ...
Source: Small - April 18, 2022 Category: Nanotechnology Authors: Youngrong Park, Ananiya A. Demessie, Addie Luo, Olena R. Taratula, Abraham S. Moses, Peter Do, Leonardo Campos, Younes Jahangiri, Cory R. Wyatt, Hassan A. Albarqi, Khashayar Farsad, Ov D. Slayden, Oleh Taratula Tags: Research Article Source Type: research

Recent advances in the use of metallic nanoparticles with antitumoral action.
Abstract The term cancer represents a set of more than 100 diseases that are caused due to an uncontrolled growth of cells; and their subsequent spread to the other tissues and organs of the body by a phenomenon, called 'metastasis'. According to the estimates provided by the World Health Organization (WHO), cancer is expected to account for about 10 million deaths per year by 2020, and 21 million cancer cases, which may lead to 13 million deaths by 2030, making cancer as the cause of highest mortality in contrast to other diseases. The search for potential therapeutics against cancer, which can reduce the side-ef...
Source: Current Medicinal Chemistry - February 13, 2018 Category: Chemistry Authors: da Silva PB, Machado RTA, Pironi AM, Alves RC, de Araujo PR, Dragalzew AC, Dalberto I, Chorilli M Tags: Curr Med Chem Source Type: research

Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy
J Colloid Interface Sci. 2022 Mar 11;617:704-717. doi: 10.1016/j.jcis.2022.03.036. Online ahead of print.ABSTRACTHeterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is glutathione (GSH), whose depletion is the cornerstone of emerging strategies in oncology, since this metabolite plays a pi...
Source: Cell Research - March 22, 2022 Category: Cytology Authors: Javier Bonet-Aleta Maria Sancho-Albero Javier Calzada-Funes Silvia Irusta Pilar Martin-Duque Jose L Hueso Jesus Santamaria Source Type: research

Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo
Int J Mol Sci. 2022 Jul 26;23(15):8241. doi: 10.3390/ijms23158241.ABSTRACTThe high mortality rate caused by atherosclerosis makes it necessary to constantly search for new and better treatments. In previous reports, chemically modified carbon-coated iron nanoparticles (Fe@C NPs) have been demonstrated a high biocompatibility and promising anti-plaque properties. To further investigate these effects, the interaction of these nanoparticles with the adipose tissue of Wistar rats (in vivo) and human atherosclerotic plaques (ex vivo) was studied. For the in vivo study, cobalt-chromium (CoCr) alloy tubes, which are used for coro...
Source: Atherosclerosis - July 28, 2022 Category: Cardiology Authors: Shamil Akhmedov Sergey Afanasyev Natalia Beshchasna Marina Trusova Ivan Stepanov Mariya Rebenkova Ekaterina Poletykina Yuri Vecherskiy Sergei Tverdokhlebov Evgeny Bolbasov Sascha Balakin Joerg Opitz Anatoly Yermakov Boris Kozlov Source Type: research

Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics
Adv Colloid Interface Sci. 2023 Apr 12;315:102903. doi: 10.1016/j.cis.2023.102903. Online ahead of print.ABSTRACTThe respiratory tract is one of the most accessible ones to exogenous nanoparticles, yet drug delivery by their means to it is made extraordinarily challenging because of the plexus of aerodynamic, hemodynamic and biomolecular factors at cellular and extracellular levels that synergistically define the safety and efficacy of this process. Here, the use of inorganic nanoparticles (INPs) for inhalable diagnostics and therapies of the lung is viewed through the prism of the history of studies on the interaction of ...
Source: Advances in Colloid and Interface Science - April 21, 2023 Category: Chemistry Authors: Vuk Uskokovi ć Source Type: research

Injectable calcium phosphate scaffold with iron oxide nanoparticles to enhance osteogenesis via dental pulp stem cells.
In conclusion, it is highly promising to incorporate γIONPs and αIONPs into CPC scaffold for bone tissue engineering, yielding substantially better stem cell attachment, spreading and osteogenic differentiation, and much greater bone mineral synthesis by the seeded cells. Therefore, novel CPC scaffolds containing γIONPs and αIONPs are promising for dental, craniofacial and orthopaedic applications to substantially enhance bone regeneration. PMID: 29355052 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 24, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Recovery of immunoglobulin G from rabbit serum using κ-carrageenan-modified hybrid magnetic nanoparticles.
Abstract Immunoglobulin G (IgG) has been used in the treatment of cancer, autoimmune diseases and neurological disorders, however, the current technologies to purify and recover IgG from biological media are of high-cost and time-consuming, resulting in high-cost products. In this sense, the search for cost-effective technologies to obtain highly pure and active IgG is highly required. The present work proposes a simple and efficient method for the purification and recovery of IgG from rabbit serum using magnetic iron oxide nanoparticles (magnetite, Fe3O4) coated with hybrid shells of a siliceous material modified...
Source: International Journal of Biological Macromolecules - February 13, 2020 Category: Biochemistry Authors: Magalhães FF, Almeida MR, Soares SF, Trindade T, Freire MG, Daniel-da-Silva AL, Tavares APM Tags: Int J Biol Macromol Source Type: research

Surface engineered iron oxide nanoparticles as efficient materials for antibiofilm application
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Source: Biotechnology and Applied Biochemistry - March 11, 2021 Category: Biochemistry Authors: Palaniyandi Velusamy, Chia ‐Hung Su, Kiruba Kannan, Govindarajan Venkat Kumar, Periasmy Anbu, Subash C.B. Gopinath Tags: Review Article Source Type: research

Molecules, Vol. 26, Pages 3002: New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles
n Vasile Adrian Ionuț Nicoară Cornelia-Ioana Ilie Anton Ficai Carmen Limban Antimicrobial resistance is one of the major public health threats at the global level, urging the search for new antimicrobial molecules. The fluorene nucleus is a component of different bioactive compounds, exhibiting diverse pharmacological actions. The present work describes the synthesis, chemical structure elucidation, and bioactivity of new O-aryl-carbamoyl-oxymino-fluorene derivatives and the contribution of iron oxide nanoparticles to enhance the desired biological activity. The antimicrobial activity assessed against three b...
Source: Molecules - May 18, 2021 Category: Chemistry Authors: Ilinca Margareta Vlad Diana Camelia Nu ță Robert Viorel Ancuceanu Miron Teodor Caproiou Florea Dumitrascu Ioana Cristina Marinas Mariana Carmen Chifiriuc Luminita Gabriela M ăruţescu Irina Zarafu Ioana Raluca Papacocea Bogdan Ștefan Vasile Adrian Ion Tags: Article Source Type: research

Zero-Valent Iron Nanoparticles: Biogenic Synthesis and their Medical Applications; Existing Challenges and Future Prospects
CONCLUSION: This review shows that there are potential cost savings applications to be made when using biogenic nZVI for medical purposes. However, the encountering challenges concluded later, along with the prospects for sustainable future development.PMID:37303179 | DOI:10.2174/1389201024666230609102243
Source: Current Pharmaceutical Biotechnology - June 12, 2023 Category: Biotechnology Authors: Minahil Hayat Sayyad Ali Raza Bukhari Muhammad Irfan Sumreen Hayat Source Type: research