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Phytochemicals Formulated as Nanoparticles: Inventions,Recent Patents and Future Prospects.
CONCLUSION: If bioavailability constraint is overcome, diseases like cancer, alzheimer, diabetes, liver disorder etc. can be effectively targeted. By doing so, the largely affected society, will breathe the relief. The present article is an attempt to elaborate and conclude on how nanoparticles have been serving as a tool to enhance the effectiveness of phytochemicals, by solubilization, dissolution and consequent bioavailability enhancements, along with in vivo targeting. To further facilitate understanding, the review has been structured as disease/disorder and phytochemical wise with focus on their nanoparticles. PM...
Source: Recent Patents on Drug Delivery and Formulation - November 24, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Investigating the Possibility of Green Synthesis of Silver Nanoparticles Using < em > Vaccinium arctostaphlyos < /em > Extract and Evaluating Its Antibacterial Properties
CONCLUSION: The synthesized nanoparticles showed more antibacterial properties against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) than gram-negative ones (Escherichia coli and Salmonella enteritidis).PMID:33997013 | PMC:PMC8110411 | DOI:10.1155/2021/5572252
Source: Biomed Res - May 17, 2021 Category: Research Authors: Sedighe Khodadadi Nafiseh Mahdinezhad Bahman Fazeli-Nasab Mohammad Javad Heidari Baratali Fakheri Abdolhossein Miri Source Type: research

Potential of < em > Azadirachta indica < /em > as a Capping Agent for Antiviral Nanoparticles against SARS-CoV-2
Biomed Res Int. 2022 Sep 15;2022:5714035. doi: 10.1155/2022/5714035. eCollection 2022.ABSTRACTA rare type of pneumonia later on referred to as COVID-19 was reported in China in December 2019. Investigations revealed that this disease is caused by a coronavirus previously identified as SARS-CoV-2, and since then, it has become a global pandemic with new strains emerging rapidly as a result of genetic mutations. Various therapeutic options are being explored in order to eradicate this pandemic even though approved vaccine candidates are being currently rolled out globally. Most medicinal plant extracts have astonishing prope...
Source: Biomed Res - September 26, 2022 Category: Research Authors: Frank Eric Tatsing Foka Nanabi Manamela Steven Maluta Mufamadi Hazel Tumelo Mufhandu Source Type: research

Anti-biofilm efficacy of green-synthesized ZnO nanoparticles on oral biofilm: In vitro and in silico study
The development of biofilm on the biotic and abiotic surfaces is the greatest challenge for health care sectors. At present times, oral infection is a common concern among people with an unhealthy lifestyle and most of these biofilms-associated infections are resistant to antibiotics. This has increased a search for the development of alternate therapeutics for eradicating biofilm-associated infection. Nanobiotechnology being an effective way to combat such oral infections may encourage the use of herbal compounds, such as bio-reducing and capping agents. Green-synthesis of ZnO nanoparticles (ZnO NP) by the use of the flor...
Source: Frontiers in Microbiology - October 3, 2022 Category: Microbiology Source Type: research

Anticholinesterase activity of Areca Catechu: In Vitro and in silico green synthesis approach in search for therapeutic agents against Alzheimer ’s disease
For many years, the primary focus has been on finding effective treatments for Alzheimer’s disease (AD), which has led to the identification of promising therapeutic targets. The necessity for AD stage-dependent optimal settings necessitated a herbal therapy strategy. The plant species Areca Catechu L. (AC) was selected based on the traditional uses against CNS-related diseases. AC leaf extract were prepared using a Soxhlet extraction method and hydroxyapatite nanoparticles (HAp-NPs) were synthesized from the same (AC-HAp-NPs). Powder X-ray diffractometer (XRD), scanning electron microscopy (SEM), transmission electron m...
Source: Frontiers in Pharmacology - November 4, 2022 Category: Drugs & Pharmacology Source Type: research

Mint leaves (Mentha arvensis) mediated CaO nanoparticles in dye degradation and their role in anti-inflammatory, anti-cancer properties
Environ Res. 2023 Jul 20:116718. doi: 10.1016/j.envres.2023.116718. Online ahead of print.ABSTRACTIn ancient times, herbal plants were considered one of the greatest gifts from nature that human beings could receive, and about 80% of these plants have medicinal uses. In traditional medicine, Mentha arvensis, commonly known as mint, has many applications, and in the present study, the mint leaf extract has been used to synthesis nanoparticles using the mint leaf extract as a biosource for the extraction of nanoparticles. In addition to having a wide range of applications in various fields, calcium oxide (CaO) nanoparticles ...
Source: Environmental Research - July 22, 2023 Category: Environmental Health Authors: Rajasree Shanmuganathan Quynh Hoang Le Sandhanasamy Devanesan Shaban R M Sayed V Devi Rajeswari Xinghui Liu G K Jhanani Source Type: research

Tulsi (Ocimum sanctum) mediated Co nanoparticles with their anti-inflammatory, anti-cancer, and methyl orange dye adsorption properties
This study investigates the economical extraction of Co nanoparticles from tulsi and its potential use in wastewater purification and biomedical applications.PMID:37507040 | DOI:10.1016/j.envres.2023.116749
Source: Environmental Research - July 28, 2023 Category: Environmental Health Authors: Han Jiang Selvam Sathiyavimal Liping Cai Sandhanasamy Devanesan Shaban R M Sayed G K Jhanani Junqing Lin Source Type: research

Biogenic Synthesis of Silver Nanoparticles Using Phyllanthus emblica Fruit Extract and Its Inhibitory Action Against the Pathogen Acidovorax oryzae Strain RS-2 of Rice Bacterial Brown Stripe
Conclusion In conclusion, this study clearly provides an economical, environmental friendly, and straightforward reproducible approach in AgNPs synthesis employing P. Emblica fruit extracts as a reducing, stabilizing, and capping agent. The biosynthesized AgNPs were characterized thoroughly by UV-Visible and Energy Dispersive X-Ray Spectroscopy, X-Ray diffraction, FTIR, TEM, HRTEM and SEM. The FTIR results found several phytochemicals responsible for the rapid reduction of ions, leading to AgNPs formation. Especially, hydroxyl groups oxidation of hydrolysate, which likely stimulated the formation of nanoparticles. In the ...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Phytofabrication of Selenium Nanoparticles From Emblica officinalis Fruit Extract and Exploring Its Biopotential Applications: Antioxidant, Antimicrobial, and Biocompatibility
Conclusion The present study shows phytofabrication of SeNPs from aqueous fruit extract of E. officinalis by facile, green, economic, and eco-friendly approach. The aqueous fruit extract of E. officinalis was rich with phenolics, flavonoids, and tannins, and was found appropriate for biosynthesis of nanoparticles. The synthesized PF-SeNPs exhibited highly stable, negative charge, amorphous nature, spherical shape and nano-size. The PF-SeNPs has presented efficient bio-potential applications, i.e., antioxidant, antimicrobial, and biocompatibility. The PF-SeNPs has shown potent free radical scavenging activity and it was fo...
Source: Frontiers in Microbiology - April 29, 2019 Category: Microbiology Source Type: research

Impact of Phytomediated Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response of < em > In Vitro < /em > Raised Shoots of < em > Ochradenus arabicus < /em >
In this study, we assessed the effects of phytomediated zinc oxide nanoparticles (ZnONPs) on shoot growth, biochemical markers, and antioxidant system response in Ochradenus arabicus, which is a medicinal plant. The shoot length and fresh and dry weights were found to be higher in groups with 5 and 10 mg/L ZnONPs than in the control. At high concentrations of ZnONPs (50, 100, and 300 mg/L), biomass was decreased in a concentration-dependent manner. The shoot number was observed to be highest at 50 mg/L among all applied concentrations of ZnONPs. The levels of the stress markers proline and TBARS were found to be higher in ...
Source: Biomed Res - December 16, 2021 Category: Research Authors: Fahad Al-Qurainy Salim Khan Saleh Alansi Mohammad Nadeem Aref Alshameri Abdel-Rhman Gaafar Mohamed Tarroum Hassan O Shaikhaldein Abdalrhaman M Salih Norah Arrak Alenezi Norah S Alfarraj Source Type: research

Antioxidant, anti-inflammatory activity of < em > Thymus vulgaris < /em > -mediated selenium nanoparticles: An < em > in vitro < /em > study
CONCLUSION: SeNps reinforced with T. vulgaris extract have a potential as an anti-inflammatory and antioxidant agent and can be used as an alternative to commercially available products.PMID:35836551 | PMC:PMC9274693 | DOI:10.4103/JCD.JCD_369_21
Source: Cancer Control - July 15, 2022 Category: Cancer & Oncology Authors: Indumathy Pandiyan Sakthi D Sri Meignana Arumugham Indiran Pradeep Kumar Rathinavelu Jayashri Prabakar S Rajeshkumar Source Type: research

Green Extracts with Metal-Based Nanoparticles for Treating Inflammatory Diseases: A Review
Curr Drug Deliv. 2023 Jun 2. doi: 10.2174/1567201820666230602164325. Online ahead of print.ABSTRACTGlobally, high death rates and poor quality of life are caused mainly by inflammatory diseases. Corticosteroids, which may have systemic side effects and would enhance the risk of infection, are the common forms of therapy. The field of nanomedicine has created composite nanoparticles that carry a pharmacological carrier and target ligands for distribution to sites of inflammation with less systemic toxicity. However, their relatively large size often causes systemic clearance. An interesting approach is metal-based nanoparti...
Source: Current Drug Delivery - June 6, 2023 Category: Drugs & Pharmacology Authors: Sonia Singh Khushi Sharma Himanshu Sharma Source Type: research