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Total 66059 results found since Jan 2013.

Using Chitosan-Coated Polymeric Nanoparticles-Thermosensitive Hydrogels in association with Limonene as Skin Drug Delivery Strategy
This study reports the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan for the sustained release and topicality of benzocaine (BZC) and topical delivery. BZC PLGA nanoparticles or nonencapsulated drugs were further incorporated into Poloxamer hydrogels (Pluronic™ F-127). The nanoparticles showed a mean diameter of 380 ± 4 nm, positive zeta potential after coating with chitosan (23.3 ± 1.7 mV), and high encapsulation efficiency (96.7 ± 0.02%). Cellular viability greater than 70% for both fibroblasts and keratinocytes was observed after treatment with nanoparticles, which is in ac...
Source: Biomed Res - April 18, 2022 Category: Research Authors: Estef ânia V R Campos Patr ícia L F Proença Tais G da Costa Renata de Lima Leonardo F Fraceto Daniele R de Araujo Source Type: research

Toxicity of silver nanoparticles on Endometrial Receptivity in Female Mice
Can J Physiol Pharmacol. 2021 Jul 20. doi: 10.1139/cjpp-2021-0094. Online ahead of print.ABSTRACTNanoparticles (NPs) have many toxic effects on fertility and can prevent successful implantation by affecting the maternal uterine tissue. Herein, by deploying thirty female NMRI mice, the effect of silver nanoparticles on the endometrium and implantation has been investigated. Using spherical silver nanoparticles of a diameter of 18-30 nm at doses of 2 and 4 mg/kg, mice in both groups were treated. Then, female mice mated with male mice. Endometrial tissue was extracted 4.5 days later. On the fourth day of pregnancy, the mice ...
Source: Canadian Journal of Physiology and Pharmacology - July 20, 2021 Category: Drugs & Pharmacology Authors: Marziyeh Ajdary Sahar Eghbali Vahid Pirhajati Mahabadi Fariborz Keyhanfar Rajender S Varma Source Type: research

Enhancement of Odor-Induced Activity in the Canine Brain by Zinc Nanoparticles: A Functional MRI Study in Fully Unrestrained Conscious Dogs.
Abstract Using noninvasive in vivo functional magnetic resonance imaging (fMRI), we demonstrate that the enhancement of odorant response of olfactory receptor neurons by zinc nanoparticles leads to increase in activity in olfaction-related and higher order areas of the dog brain. To study conscious dogs, we employed behavioral training and optical motion tracking for reducing head motion artifacts. We obtained brain activation maps from dogs in both anesthetized state and fully conscious and unrestrained state. The enhancement effect of zinc nanoparticles was higher in conscious dogs with more activation in higher...
Source: Chemical Senses - October 12, 2015 Category: Biochemistry Authors: Jia H, Pustovyy OM, Wang Y, Waggoner P, Beyers RJ, Schumacher J, Wildey C, Morrison E, Salibi N, Denney TS, Vodyanoy VJ, Deshpande G Tags: Chem Senses Source Type: research

Respiratory toxicity of TiO2 nanoparticles after intravenous instillation: an experimental study.
CONCLUSIONS: We suggest low biopersistence and relatively rapid elimination of TiO2 nanoparticles from the lung under used experimental conditions. PMID: 30419618 [PubMed - in process]
Source: Central European Journal of Public Health - November 13, 2018 Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research

Biochemical and morphological changes in rats exposed to platinum nanoparticles
This study evaluated the toxicity potential of platinum (Pt) nanoparticles in Wistar rats. Wistar rats weighing between 180 and 193 g were randomly assigned into four groups. Animals in group 1 served as the control and received distilled water. Those in groups 2, 3, and 4 were administered with 10, 50, and 100 mg/kg body weight of Pt nanoparticles, respectively. At the end of treatments, the rats were fasted for 24 h and sacrificed under mild anesthesia. The blood and vital organs were collected and used for the biochemical and histopathological examinations. Pt nanoparticles caused significant alterations to the rat o...
Source: Comparative Clinical Pathology - May 5, 2016 Category: Pathology Source Type: research

Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice
Publication date: 6 March 2018 Source:Neuroscience Letters, Volume 668 Author(s): Tao Wang, Olivia Hurwitz, Steven G. Shimada, Daofeng Tian, Feng Dai, Jiangbing Zhou, Chao Ma, Robert H. LaMotte Bupivacaine is a commonly used local anesthetic in postoperative pain management. We evaluated the effects of a prolonged, local delivery of bupivacaine on pain behavior accompanying a chronic compression of the dorsal root ganglion (CCD) – an animal model of radicular pain. Poly(lactide-coglycolide) (PLGA) nanoparticles encapsulating bupivacaine were injected unilaterally into the L3 and L4 DRGs of mice just before producing CCD...
Source: Neuroscience Letters - February 4, 2018 Category: Neuroscience Source Type: research

Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac
ConclusionsNovel nano-enhanced radiotherapy with gadolinium-containing nanoparticles is ideally suited for implementation on an MRI-linac, allowing a workflow with time-of-treatment imaging. Live irradiations using this treatment workflow, carried out for the first time at the Australian MRI-linac, confirm the safety and feasibility of performing MRI-guided radiotherapy with AGuIX® nanoparticles. Follow-up studies are needed to demonstrate on an MRI-linac the radiation enhancement effects previously shown with conventional radiotherapy.
Source: Cancer Nanotechnology - October 5, 2020 Category: Cancer & Oncology Source Type: research

Albumin covering maintains endothelial function upon magnetic iron oxide nanoparticles intravenous injection in rats
J Biomed Mater Res A. 2021 Apr 3. doi: 10.1002/jbm.a.37193. Online ahead of print.ABSTRACTMagnetic iron oxide nanoparticles (IONP) present the promising instrument for broad-spectrum of clinical applications, for example, targeted drug delivery. Reactivity of nanoparticles depends on their surface area and material. In the blood plasma IONP are getting covered with an albumin crown, so it was decided to test this shell for biocompatibility. Male Wistar rats were anesthetized and underwent laparotomy. Abdominal aorta was connected to external hemodynamic loop with regulated blood flow. Hind body quarter got step-like blood ...
Source: Biomed Res - April 3, 2021 Category: Research Authors: Yana G Toropova Irina A Zelinskaya Mariya N Gorshkova Daria S Motorina Dmitriy V Korolev Fedor S Velikonivtsev Kamil G Gareev Source Type: research