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Single-cell resolution in high-resolution synchrotron X-ray CT imaging with gold nanoparticles
Gold nanoparticles are excellent intracellular markers in X-ray imaging. Having shown previously the suitability of gold nanoparticles to detect small groups of cells with the synchrotron-based computed tomography (CT) technique both ex vivo and in vivo, it is now demonstrated that even single-cell resolution can be obtained in the brain at least ex vivo. Working in a small animal model of malignant brain tumour, the image quality obtained with different imaging modalities was compared. To generate the brain tumour, 1 × 105 C6 glioma cells were loaded with gold nanoparticles and implanted in the right cerebral hemisphere...
Source: Journal of Synchrotron Radiation - December 11, 2013 Category: Physics Authors: Schültke, E.Menk, R.Pinzer, B.Astolfo, A.Stampanoni, M.Arfelli, F.Harsan, L.-A.Nikkhah, G. Tags: animal model brain tumour high-resolution imaging gold nanoparticles X-ray CT research papers Source Type: research

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke
as Endres, Ulrich Dirnagl & Tracy D Farr
Source: Journal of Cerebral Blood Flow - February 27, 2013 Category: Neurology Authors: Christoph HarmsAnna Lena DatwylerFrank WiekhorstLutz TrahmsRandall LindquistEyk SchellenbergerSusanne MuellerGunnar SchützFarnoosh RoohiAndreas IdeMartina FüchtemeierKaren GertzGolo KronenbergUlrike HarmsMatthias EndresUlrich DirnaglTracy D Farr Tags: inflammation iron oxide nanoparticles magnetic resonance imaging stroke Source Type: research

Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia
This study is the first to describe nanoparticles that enable systemically delivered magnetic hyperthermia for endometriosis treatment. When subjected to an alternating magnetic field (AMF), these hexagonal iron-oxide nanoparticles exhibit extraordina ry heating efficiency that is 6.4× greater than their spherical counterparts. Modifying nanoparticles with a peptide targeted to vascular endothelial growth factor receptor 2 (VEGFR-2) enhances their endometriosis specificity. Studies in mice bearing transplants of macaque endometriotic tissue reve al that, following intravenous injection at a low dose (3 mg per kg), these ...
Source: Small - April 18, 2022 Category: Nanotechnology Authors: Youngrong Park, Ananiya A. Demessie, Addie Luo, Olena R. Taratula, Abraham S. Moses, Peter Do, Leonardo Campos, Younes Jahangiri, Cory R. Wyatt, Hassan A. Albarqi, Khashayar Farsad, Ov D. Slayden, Oleh Taratula Tags: Research Article Source Type: research

Antimicrobial magnetic nanoparticles based-therapies for controlling infectious diseases
Publication date: Available online 16 November 2018Source: International Journal of PharmaceuticsAuthor(s): Gisele Regina Rodrigues, Carlos López-Abarrategui, Inés de la Serna Gómez, Simoni Campos Dias, Anselmo J. Otero-González, Octavio Luiz FrancoAbstractIn the last years, the antimicrobial resistance against antibiotics has become a serious health issue, arise as global threat. This has generated a search for new strategies in the progress of new antimicrobial therapies. In this context, different nanosystems with antimicrobial properties have been studied. Specifically, magnetic nanoparticles seem to be very attrac...
Source: International Journal of Pharmaceutics - November 17, 2018 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 24, Pages 4629: Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging
Montpeyó Amiens The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron–iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. Here we report the synthesis of 10 nm large Fe@FeOx nanoparticles, their coating with a 11 nm thick layer of dense silica and functionalization by 5 kDa PEG chains to improve their biocompatibility. The nanomaterial...
Source: Molecules - December 16, 2019 Category: Chemistry Authors: Mathieu Coppel Respaud Nguyen Boutry Laurent Stanicki Henoumont Novio Lorenzo Montpey ó Amiens Tags: Article Source Type: research

Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets
CONCLUSION: In the present study, cRGD-platelet@MnO/MSN@PPARα/LXRα nanoparticles with high safety and the capacity to target vulnerable plaques of AS were successfully established. They showed better performance on MRI images and treatment effects on AS by promoting cholesterol efflux through the regulation of ABCA1. These findings might address the problems of off-target effects and side effects of nanoparticle-mediated drug delivery, which will enhance the efficiency of AS treatment and provide new ideas for the clinical treatment of AS.PMID:36211824 | PMC:PMC9537012 | DOI:10.1155/2022/6006601
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Wei Zhang Zheng Lv Yupeng Zhang Subash C B Gopinath Yi Yuan Deyou Huang Liu Miao Source Type: research

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: possibilities and challenges
Publication date: Available online 18 December 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Zahra Bakhtiary, Amir Ata Saei, Mohammad J. Hajipour, Mohammad Raoufi, Ophir Vermesh, Morteza Mahmoudi Nanomedicine, the integration of nanotechnological tools in medicine demonstrated promising potential to revolutionize the diagnosis and treatment of various human health conditions. Nanoparticles (NPs) have shown much promise in diagnostics of cancer, especially since they can accommodate targeting molecules on their surface, which search for specific tumor cell receptors upon injection into th...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - December 18, 2015 Category: Nanotechnology Source Type: research

Fucoidan-based nanoparticles: Preparations and applications
Int J Biol Macromol. 2022 Jul 13:S0141-8130(22)01498-2. doi: 10.1016/j.ijbiomac.2022.07.068. Online ahead of print.ABSTRACTNanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparticles have been synthesized using microwave, emulsion, solvent evaporation, green synthesis, polyelectrolyte self-assembly, precipitation, and ultrasonication...
Source: International Journal of Biological Macromolecules - July 16, 2022 Category: Biochemistry Authors: Jayachandran Venkatesan Sesha Subramanian Murugan Gi Hun Seong Source Type: research

The Potential of Gadolinium Ascorbate Nanoparticles as a Safer Contrast Agent
J Phys Chem B. 2022 Dec 27. doi: 10.1021/acs.jpcb.2c05831. Online ahead of print.ABSTRACTThere have been health concerns raised against the use of gadolinium (Gd)-based magnetic resonance imaging contrast agents. The primary observation is that Gd ions are prone to leaking into the bloodstream, causing nephrogenic systemic fibrosis as one of the side effects. In addition, such leakage of the ions inhibits easy clearance from the body. Herein we propose that Gd-ascorbate nanoparticles could be one of the safer choices as they are rather stable in aqueous dispersion and they do not get affected by Zn or Fe ions in the medium...
Source: Health Physics - December 27, 2022 Category: Physics Authors: Ujjala Dey Arun Chattopadhyay Source Type: research

Mn < sup > 2+ < /sup > -doped Prussian blue nanoparticles for T1-T2 dual-mode magnetic resonance imaging and photothermal therapy < em > in vitro < /em >
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Jun 20;41(6):909-915. doi: 10.12122/j.issn.1673-4254.2021.06.14.ABSTRACTOBJECTIVE: To prepare Mn2+-doped Prussian blue nanoparticles (Mn-PB NPs) for T1-T2 dual-mode magnetic resonance imaging (MRI) and photothermal therapy in vitro.OBJECTIVE: Mn-PB NPs were prepared based on manganese chloride, ferrous chloride and potassium ferricyanide using the microemulsion method. The performance of T1-T2 dual-mode MRI with Mn-PB NPs and the photothermal property of the nanoparticles were assessed. CCK-8 assay and AM/PI double staining were used to evaluate the effect of photothermal therapy in vitr...
Source: Journal of Southern Medical University - July 9, 2021 Category: Universities & Medical Training Authors: G He Q Tao C Liu D Zhang Y Zhou R Liu Source Type: research