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Specialty: Cytology
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Total 78932 results found since Jan 2013.
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
J Nanopart Res. 2023;25(3):43. doi: 10.1007/s11051-023-05690-w. Epub 2023 Feb 27.ABSTRACTRapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this ...
Source: Cell Research - March 6, 2023 Category: Cytology Authors: Reza Abbasi Ghazal Shineh Mohammadmahdi Mobaraki Sarah Doughty Lobat Tayebi Source Type: research
Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy
J Colloid Interface Sci. 2022 Mar 11;617:704-717. doi: 10.1016/j.jcis.2022.03.036. Online ahead of print.ABSTRACTHeterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is glutathione (GSH), whose depletion is the cornerstone of emerging strategies in oncology, since this metabolite plays a pi...
Source: Cell Research - March 22, 2022 Category: Cytology Authors: Javier Bonet-Aleta Maria Sancho-Albero Javier Calzada-Funes Silvia Irusta Pilar Martin-Duque Jose L Hueso Jesus Santamaria Source Type: research
In vitro antioxidant, anticancer, anti-inflammatory, anti-diabetic and anti-Alzheimer potentials of innovative macroalgae bio-capped silver nanoparticles
Environ Sci Pollut Res Int. 2022 Apr 9. doi: 10.1007/s11356-022-20039-x. Online ahead of print.ABSTRACTThe antagonistic side effects of chemical medications led to the search for safe strategies such as biogenic agents. Correspondingly, this study aims to create biogenic, appropriate, auspicious and innovative therapeutic agents like Galaxaura elongata {GE}, Turbinaria ornata {TO} and Enteromorpha flexuosa {EF} macroalgae-based silver nanoparticles (Ag-NPs). The Ag+ reduction and the creation of Ag[GE]-NPs, Ag[TO]-NPs and Ag[EF]-NPs have been validated using UV-visible spectroscopy, Fourier transform infrared spectroscopy ...
Source: Cell Research - April 9, 2022 Category: Cytology Authors: Manal N Abdel Azeem Osama M Ahmed Mohamed Shaban Khaled N M Elsayed Source Type: research
Anti-CD44 and EGFR Dual-Targeted Solid Lipid Nanoparticles for Delivery of Doxorubicin to Triple-Negative Breast Cancer Cell Line: Preparation, Statistical Optimization, and < em > In Vitro < /em > Characterization
CONCLUSION: Overall, the finding of this investigation suggested that SLNs/DOX/Dexa/CD44/EGFR could be a promising new enhanced anticancer delivery system and deserved further preclinical consideration.PMID:35845934 | PMC:PMC9279089 | DOI:10.1155/2022/6253978
Source: Cell Research - July 18, 2022 Category: Cytology Authors: Farnosh Darabi Massoud Saidijam Fatemeh Nouri Reza Mahjub Meysam Soleimani Source Type: research
Hepatic and renal cellular cytotoxic effects of heparin-coated superparamagnetic Iron oxide nanoparticles
CONCLUSIONS: Collectively, it is possible that UFH- coated SPIO nanoparticles can be used as alternative negative contrast agents.PMID:34736539 | DOI:10.1186/s40824-021-00241-7
Source: Cell Research - November 5, 2021 Category: Cytology Authors: Yong Hwa Hwang Youn-Jung Kim Dong Yun Lee Source Type: research
Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture
CONCLUSION: Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture. In turn, this influenced the extent of internalization and localization of accumulated nanoparticles within cells. The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.PMID:35233729 | PMC:PMC8887940 | DOI:10.1007/s11095-022-03202-4
Source: Cell Research - March 2, 2022 Category: Cytology Authors: M C B Lira-Nogueira V P Gibson V Nicolas N S Santos-Magalh ães C Vauthier Source Type: research
Assessing the Cytotoxicity of TiO < sub > 2-x < /sub > Nanoparticles with a Different Ti < sup > 3+ < /sup > (Ti < sup > 2+ < /sup > )/Ti < sup > 4+ < /sup > Ratio
In this study, we explored the cytotoxicity of TiO2-x nanoparticles with a different Ti3+(Ti2+)/Ti4+ ratio and analyzed the efficiency of eryptosis indices as a tool in nanotoxicology. Two types of TiO2-x nanoparticles (NPs) were synthesized by the hydrolysis of titanium alkoxide varying the nitric acid content in the hydrolysis mixture. Transmission electron microscopy (TEM) images show that 1-TiO2-x and 2-TiO2-x NPs are 5 nm in size, whereas X-ray photoelectron spectroscopy (XPS) reveals different Ti3+ (Ti2+)/Ti4+ ratios in the crystal lattices of synthesized NPs. 1-TiO2-x nanoparticles contained 54% Ti4+, 38% Ti3+, and ...
Source: Cell Research - August 27, 2022 Category: Cytology Authors: Volodymyr Prokopiuk Svetlana Yefimova Anatolii Onishchenko Valeriy Kapustnik Valeriy Myasoedov Pavel Maksimchuk Dmytro Butov Irina Bespalova Anton Tkachenko Source Type: research
Ligand Chemistry in Antitumor Theranostic Nanoparticles
Acc Chem Res. 2023 May 23. doi: 10.1021/acs.accounts.3c00151. Online ahead of print.ABSTRACTConspectusTheranostic nanoparticles' potential in tumor treatment has been widely acknowledged thanks to their capability of integrating multifaceted functionalities into a single nanosystem. Theranostic nanoparticles are typically equipped with an inorganic core with exploitable physical properties for imaging and therapeutic functions, bioinert coatings for improved biocompatibility and immunological stealth, controlled drug-loading-release modules, and the ability to recognize specific cell type for uptake. Integrating multiple f...
Source: Cell Research - May 23, 2023 Category: Cytology Authors: Guanyou Lin Miqin Zhang Source Type: research
Research Progress of Cell Membrane Biomimetic Nanoparticles for Tumor Therapy
Nanoscale Res Lett. 2022 Mar 22;17(1):36. doi: 10.1186/s11671-022-03673-9.ABSTRACTNanoparticles have unique properties and high design flexibility, which are thought to be safe, site-specific, and efficient drug delivery systems. However, nanoparticles as exogenous materials can provide recognition and be eliminated by the body's immune system, which considerably restricts their applications. To overcome these drawbacks, natural cell membrane coating method has attracted great attention in the field of drug delivery systems, which can prolong nanoparticles blood circulation time and avoiding the capture as well as eliminat...
Source: Cell Research - March 22, 2022 Category: Cytology Authors: Xuefen Zhao Chao Yan Source Type: research
Antibody-conjugated silica-coated gold nanoparticles in targeted therapy of cervical cancer
This study aimed to synthesize silica-coated gold (Au@SiO2) nanoparticles coupled to antibodies against the scavenger receptor class B type I (SR-BI) and investigate their potential ability of visual tracking and treatment of cervical cancer. The fluorescein isothiocyanate (FITC)-labeled Au@SiO2-SR-BI antibody was synthesized, followed by characterization determination. The expression and location of SR-BI protein in cervical cancer cells were respectively detected by western blot and immunofluorescence assays. The effects of nanoparticles on cancer cells were determined by adsorption assay and apoptosis detection, respect...
Source: Cell Research - April 15, 2022 Category: Cytology Authors: Hui Yu Ruxin Zheng Fei Lei Wanyue Wang Weikang Guo Lu Zhang Yunduo Liu Xiuwei Chen Yaoxian Wang Source Type: research
Highly tailorable gellan gum nanoparticles as a platform for the development of T cell activator systems
CONCLUSIONS: Our results show that GG nanoparticles were successfully used as a highly tailorable T cell activator system platform capable of T cell expansion and re-education.PMID:36180901 | PMC:PMC9523970 | DOI:10.1186/s40824-022-00297-z
Source: Cell Research - September 30, 2022 Category: Cytology Authors: Daniel B Rodrigues Helena R Moreira Mariana T Cerqueira Alexandra P Marques Ant ónio G Castro Rui L Reis Rog ério P Pirraco Source Type: research
Importance of surface charge of soot nanoparticles in determining inhalation toxicity in mice
In conclusion, carbonaceous nanoparticles carrying electric ions, especially positive-charged, are particularly toxic when inhaled and should be of concern in terms of pulmonary health protection.PMID:36223019 | DOI:10.1007/s11356-022-23444-4
Source: Cell Research - October 12, 2022 Category: Cytology Authors: Ta-Chih Hsiao Chia-Li Han Tzu-Ting Yang Yueh-Lun Lee Yu-Fang Shen Yu-Teng Jheng Chii-Hong Lee Jer-Hwa Chang Kian Fan Chung Han-Pin Kuo Hsiao-Chi Chuang Source Type: research
Targeting reactive astrocytes by pH-responsive ligand-bonded polymeric nanoparticles in spinal cord injury
Drug Deliv Transl Res. 2023 Jan 23. doi: 10.1007/s13346-023-01300-3. Online ahead of print.ABSTRACTIn spinal cord injuries, axonal regeneration decreases with the activation of astrocytes followed by glial scar formation. Targeting reactive astrocytes has been recently performed by unsafe viral vectors to inhibit gliosis. In the current study, biocompatible polymeric nanoparticles were selected as an alternative for viruses to target reactive astrocytes for further drug/gene delivery applications. Lipopolysaccharide-bonded chitosan-quantum dots/poly acrylic acid nanoparticles were prepared by ionic gelation method to targe...
Source: Cell Research - January 23, 2023 Category: Cytology Authors: Parinaz Sabourian Masoud Frounchi Sahar Kiani Shohreh Mashayekhan Masoumeh Zarei Kheirabadi Yasaman Heydari Seyed Sajad Ashraf Source Type: research
Curcumin encapsulated zein/caseinate-alginate nanoparticles: Release and antioxidant activity under < em > in vitro < /em > simulated gastrointestinal digestion
Curr Res Food Sci. 2023 Feb 18;6:100463. doi: 10.1016/j.crfs.2023.100463. eCollection 2023.ABSTRACTCurcumin-loaded zein/sodium caseinate-alginate nanoparticles were successfully fabricated using a pH-shift method/electrostatic deposition method. These nanoparticles produced were spheroids with a mean diameter of 177 nm and a zeta-potential of -39.9 mV at pH 7.3. The curcumin was an amorphous, and the content in the nanoparticles was around 4.9% (w/w) and the encapsulation efficiency was around 83.1%. Aqueous dispersions of the curcumin-loaded nanoparticles were resistant to aggregation when subjected to pH changes (pH 7.3 ...
Source: Cell Research - March 2, 2023 Category: Cytology Authors: Yunfei Huang Yiling Zhan Guangyi Luo Yan Zeng David Julian McClements Kun Hu Source Type: research
