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Total 80302 results found since Jan 2013.

Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury
& Mark S Kindy
Source: Journal of Cerebral Blood Flow - February 6, 2013 Category: Neurology Authors: Xiang YunVictor D MaximovJin YuHong ZhuAlexey A VertegelMark S Kindy Tags: anti-oxidants antibody cerebral ischemia nanoparticles superoxide dismutase Source Type: research

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke
as Endres, Ulrich Dirnagl & Tracy D Farr
Source: Journal of Cerebral Blood Flow - February 27, 2013 Category: Neurology Authors: Christoph HarmsAnna Lena DatwylerFrank WiekhorstLutz TrahmsRandall LindquistEyk SchellenbergerSusanne MuellerGunnar SchützFarnoosh RoohiAndreas IdeMartina FüchtemeierKaren GertzGolo KronenbergUlrike HarmsMatthias EndresUlrich DirnaglTracy D Farr Tags: inflammation iron oxide nanoparticles magnetic resonance imaging stroke Source Type: research

Systemically administered brain-targeted nanoparticles transport peptides across the blood–brain barrier and provide neuroprotection
Systemically administered brain-targeted nanoparticles transport peptides across the blood–brain barrier and provide neuroprotection Journal of Cerebral Blood Flow & Metabolism advance online publication, December 10 2014. doi:10.1038/jcbfm.2014.220 Authors: Muge Yemisci, Secil Caban, Yasemin Gursoy-Ozdemir, Sevda Lule, Ramon Novoa-Carballal, Ricardo Riguera, Eduardo Fernandez-Megia, Karine Andrieux, Partick Couvreur, Yilmaz Capan & Turgay Dalkara
Source: Journal of Cerebral Blood Flow - December 10, 2014 Category: Neurology Authors: Muge YemisciSecil CabanYasemin Gursoy-OzdemirSevda LuleRamon Novoa-CarballalRicardo RigueraEduardo Fernandez-MegiaKarine AndrieuxPartick CouvreurYilmaz CapanTurgay Dalkara Tags: cerebrovascular disease/stroke caspases growth factors/cytokines nanoparticles neuroprotection Source Type: research

Nanoparticles and nanoformulated drugs as promising delivery system in treatment of microbial-induced CNS infection: a systematic review of literature
AbstractCentral nervous system (CNS) infection is a global health problem with high rate of mortality and associated morbidities. Viruses, bacteria, fungi, and protozoa parasites are the main cause of CNS infection. Various medications are currently used for treatment of brain infections, but most of them do not have enough efficiency because the majority of conventional drugs cannot pass the blood –brain barrier (BBB) to combat the pathogens. Nanotechnology has provided promising approaches to solve this issue, since nanoparticles (NPs) can facilitate the drugs entrance through the BBB. Herein, we systematically reviewe...
Source: Journal of NeuroVirology - July 5, 2021 Category: Neurology Source Type: research

Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions
Prog Brain Res. 2021;265:385-406. doi: 10.1016/bs.pbr.2021.06.015. Epub 2021 Aug 13.ABSTRACTNanoparticles affect blood-brain barrier (BBB) and brain edema formation resulting in sensory-motor dysfunction. Exposure of Mn nanoparticles from industrial sources in humans could target basal ganglia resulting in Parkinson's disease. In present investigation, Mn exposure on brain pathology in a rat model was examined. Rats received Mn nanoparticles (30-40nm size) in a dose of 10 or 20mg/kg, i.p. once daily for 7 days and behavioral dysfunctions on Rota Rod performance, inclined plane angle and grid-walking tests as well as gait p...
Source: Brain Research - September 25, 2021 Category: Neurology Authors: Aruna Sharma Lianyuan Feng Dafin F Muresanu Seaab Sahib Z Ryan Tian Jos é Vicente Lafuente Anca D Buzoianu Rudy J Castellani Ala Nozari Lars Wiklund Hari Shanker Sharma Source Type: research

Comparison of the possible histopathological changes of the rat neonatal cerebellum induced by toxic and nontoxic doses of biological silver nanoparticles with chemical silver nanoparticles
ConclusionIn contrast with chemical nanoparticles, biological nanoparticles have less significant effect on the cerebellum cells.
Source: Brain and Behavior - August 1, 2021 Category: Neurology Authors: Hanieh Alsadat Mirkatuli, Mohammadhasan Baghbani, Behrooz Yahyaei Tags: ORIGINAL RESEARCH Source Type: research

Infodemiology of autoimmune encephalitis, autoimmune seizures, and autoimmune epilepsy: An analysis of online search behavior using Google Trends
CONCLUSIONS: This study showed an uptrend in the online search interest on autoimmune encephalitis, autoimmune seizures, and autoimmune epilepsy over time, which may reflect the increased awareness of the condition by the public and the medical community. Information on online health information-seeking behavior may be obtained from Google Trends data despite its limitations.PMID:35623205 | DOI:10.1016/j.yebeh.2022.108730
Source: Epilepsy and Behaviour - May 27, 2022 Category: Neurology Authors: Katrina T Roberto Roland Dominic G Jamora Kevin Michael C Moalong Adrian I Espiritu Source Type: research

Temozolomide-loaded PLGA nanoparticles to treat glioblastoma cells: a biophysical and cell culture evaluation.
CONCLUSIONS: PLGA nanoparticles are not suitable as carriers of TMZ for glioblastoma drug delivery on account of the overall high IC50 values of glioblastoma cells to TMZ and poor loading and encapsulation efficiencies. Further biotechnological developments aimed at improving the loading of TMZ in PLGA nanoparticles or co-delivery of small molecule sensitizers to improve the response of human glioblastoma cells to TMZ are required for this approach to be considered and optimized for future clinical translation. PMID: 26905383 [PubMed - as supplied by publisher]
Source: Neurological Research - February 26, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Effect of insulin-coated trimethyl chitosan nanoparticles on IGF-1, IGF-2, and apoptosis in the hippocampus of diabetic male rats.
CONCLUSIONS: The present study showed the efficacy of insulin coated nanoparticle in oral route manner that can be tested in Phase I- III clinical trials. However, a behavioral study could reveal the efficacy of insulin-loaded nanoparticles in the improvement of cognitive changes through the modulation of IGF-1 and IGF-2 levels in the hippocampus. PMID: 29889083 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The attentional template in high and low similarity search: Optimal tuning or tuning to relations?
Cognition. 2021 Apr 13;212:104732. doi: 10.1016/j.cognition.2021.104732. Online ahead of print.ABSTRACTThe attentional template is often described as the mental representation that drives attentional selection and guidance, for instance, in visual search. Recent research suggests that this template is not a veridical representation of the sought-for target, but instead an altered representation that allows more efficient search. The current paper contrasts two such theories. Firstly, the Optimal Tuning account which posits that the attentional template shifts to an exaggerated target value to maximise the signal-to-noise r...
Source: Cognition - April 16, 2021 Category: Neurology Authors: Zachary Hamblin-Frohman Stefanie I Becker Source Type: research

Serial, self-terminating search can be distinguished from others: Evidence from multi-target search data
Cognition. 2021 Apr 19;212:104736. doi: 10.1016/j.cognition.2021.104736. Online ahead of print.ABSTRACTHow do people find a target among multiple stimuli? The process of searching for a target among distractors has been a fundamental issue in human perception and cognition, evoking raging debates. Some researchers argued that search should be carried out by serially allocating focal attention to each item until the target is found. Others claimed that multiple stimuli, sharing a finite amount of processing resource, could be processed in parallel. This strict serial/parallel dichotomy in visual search has been challenged a...
Source: Cognition - April 22, 2021 Category: Neurology Authors: Jongmin Lee Koeun Jung Suk Won Han Source Type: research