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Specialty: Urology & Nephrology
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Total 98151 results found since Jan 2013.
Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland,
Brandee L. Branche,
Lauren E. Howard,
Robert J. Hamilton,
William J. Aronson,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research
Inhaled Silica Nanoparticles Causes Chronic Kidney Disease in Rats
CONCLUSIONS: Inhaled SiNPs causes chronic kidney injury that progresses despite stopping the SiNP administration. These findings are consistent with the hypothesis that human exposure to amorphous silica nanoparticles found in burned sugarcane fields could have a participatory role in chronic kidney disease of unknown etiology.PMID:35635324 | DOI:10.1152/ajprenal.00021.2022
Source: Am J Physiol Renal P... - May 31, 2022 Category: Urology & Nephrology Authors: Fumihiko Sasai Keegan Rogers David J Orlicky Arthur Stem Joshua Schaeffer Gabriela Garcia Jacob Fox Matthew S Ray Jaime Butler-Dawson Marvin Gonzalez-Quiroz Ricardo Leiva Gangadhar Taduri Sirirat Anutrakulchai Vidhya Venugopal Magdalena Madero Jason Glase Source Type: research
Selling blood and gametes during tough economic times: insights from Google search.
CONCLUSION: Google search volume data for search terms relating to sperm, egg, and blood donation increase during economic downturns. This finding suggests gamete and bodily fluid donations are influenced by market forces like other commodities. Google search may be useful for predicting blood donation trends but is more limited in predicting actual semen and oocyte donation patterns.
PMID: 26432967 [PubMed - in process]
Source: Canadian Journal of Urology - October 5, 2015 Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Newly Developed Biocompatible Material: Dispersible Titanium-Doped Hydroxyapatite Nanoparticles Suitable for Antibacterial Coating on Intravascular Catheters.
Authors: Furuzono T, Okazaki M, Azuma Y, Iwasaki M, Kogai Y, Sawa Y
Abstract
BACKGROUND: Thirteen patients with chlorhexidine-silver sulfadiazine-impregnated catheters have experienced serious anaphylactic shock in Japan. These adverse reactions highlight the lack of commercially available catheters impregnated with strong antibacterial chemical agents. A system should be developed that can control both biocompatibility and antibacterial activity.
SUMMARY: Hydroxyapatite (HAp) is biocompatible with bone and skin tissues. To provide antibacterial activity by using an external physical stimulus, titanium (Ti) ion...
Source: Contributions to Nephrology - December 14, 2016 Category: Urology & Nephrology Tags: Contrib Nephrol Source Type: research
Targeting inflammatory monocytes by immune-modifying nanoparticles prevents acute kidney allograft rejection
In this study, immune-modifying nanoparticles attenuated acute rejection in a fully MHC-mismatched murine model of kidney allograft rejection. Nanoparticles prevented monocyte accumulation within the graft and inhibited both innate and adaptive alloimmunity. Our experimental findings identify immune-modifying nanoparticles as a potential induction agent in kidney transplantation.
Source: Kidney International - July 15, 2022 Category: Urology & Nephrology Authors: Christina Lai, Steven Chadban, Yik Wen Loh, Tony Kwan, Chuanmin Wang, Julian Singer, Paula Niewold, Zheng Ling, Alanna Spiteri, Daniel Getts, Nicholas King, Huiling Wu Tags: basic research Source Type: research
Applications of Nanoparticles in the Detection and Treatment of Kidney Diseases
Nanoparticles have emerged in the medical field as a technology well suited for the diagnosis and treatment of various disease states. They have been heralded as efficacious in terms of improved therapeutic efficacy and reduction of treatment side effects in some cases. Various nanomaterials have been developed that can be tagged with targeting moieties as well as with drug delivery and imaging capability or a combination of both as a theranostic agent. These nanomaterials have been investigated for treatment and detection of various pathological conditions. The emphasis of this review is to demonstrate current research an...
Source: Advances in Chronic Kidney Disease - November 1, 2013 Category: Urology & Nephrology Authors: Chris Brede, Vinod Labhasetwar Tags: Articles Source Type: research
Targeting Therapeutics to the Glomerulus With Nanoparticles
Nanoparticles are an enabling technology for the creation of tissue-/cell-specific therapeutics that have been investigated extensively as targeted therapeutics for cancer. The kidney, specifically the glomerulus, is another accessible site for nanoparticle delivery that has been relatively overlooked as a target organ. Given the medical need for the development of more potent, kidney-targeted therapies, the use of nanoparticle-based therapeutics may be one such solution to this problem. Here, we review the literature on nanoparticle targeting of the glomerulus. Specifically, we provide a broad overview of nanoparticle-bas...
Source: Advances in Chronic Kidney Disease - November 1, 2013 Category: Urology & Nephrology Authors: Jonathan E. Zuckerman, Mark E. Davis Tags: Articles Source Type: research
Protective effect of beta‐carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue
In this study, the effects of beta‐carotene (BC) on testicular germ cell apoptosis arising from titanium dioxide nanoparticles (NTiO2) have been evaluated. In NTiO2‐treated mice, expression of apoptotic related genes including Bid, FasL, caspase‐3 and p38MAPK was significantly increased. Measurement apoptosis using TUNEL method showed significant increase in apoptotic index of germ cells in NTiO2‐treated mice (P < 0.05). TUNEL assessments showed that the increase of apoptotic index of testicular germ cells in NTiO2‐treated mice was reversed by BC. Beta‐carotene pre‐treatment could also effectively attenu...
Source: Andrologia - October 3, 2014 Category: Urology & Nephrology Authors: M. Orazizadeh, E. Daneshi, M. Hashemitmar, F. Absalan, L. Khorsandi Tags: Original Article Source Type: research
Anatase titanium dioxide nanoparticles in mice: evidence for induced structural and functional sperm defects after short-, but not long-, term exposure.
Abstract
Titanium dioxide (TiO 2 ) nanoparticles (TNPs) are widely used commercially and exist in a variety of products. To determine if anatase TNPs (ATNPs) in doses smaller than previously used reach the scrotum after entry in the body at a distant location and induce sperm defects, 100% ATNP (2.5 or 5 mg kg-1 body weight) was administered intraperitoneally to adult males for three consecutive days, followed by sacrifice 1, 2, 3, or 5 weeks later (long-) or 24, 48 or 120 h (short-term exposure). Transmission electron microscopy revealed the presence of ANTP in scrotal adipose tissues collected 120 h postinjectio...
Source: Asian Journal of Andrology - October 24, 2014 Category: Urology & Nephrology Authors: Smith MA, Michael R, Aravindan RG, Dash S, Shah SI, Galileo DS, Martin-DeLeon PA Tags: Asian J Androl Source Type: research
Use of nanoparticles to monitor human mesenchymal stem cells transplanted into penile cavernosum of rats with erectile dysfunction.
CONCLUSIONS: Transplanted SPION-MSCs existed for up to 4 weeks in the cavernous nerve injured cavernosa of rats. Erectile dysfunction recovered and could be monitored by MRI.
PMID: 25874041 [PubMed - in process]
Source: Korean Journal of Urology - April 17, 2015 Category: Urology & Nephrology Tags: Korean J Urol Source Type: research
Magnetic Sentinel Lymph Node Detection in Prostate Cancer after intraprostatic Injection of Superparamagnetic Iron Oxide Nanoparticles.
Abstract
In prostate cancer, reliable information about the lymph node status is of great importance for accurate staging and the optimal planning of treatment. Despite recent advances in imaging, the histological detection of metastases, or pelvic lymphadenectomy (PLND), continues to be the most reliable method for lymph node staging in clinically localised prostate cancer, especially as this procedure enables the detection of small or micrometastases. Radioisotope-guided sentinel PLND (sPLND) demonstrates high sensitivity in the detection of lymph node metastases as well as low morbidity in prostate cancer becau...
Source: Aktuelle Urologie - March 21, 2017 Category: Urology & Nephrology Authors: Winter A, Engels S, Kowald T, Paulo TS, Gerullis H, Chavan A, Wawroschek F Tags: Aktuelle Urol Source Type: research
