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Specialty: Cardiology
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Total 109230 results found since Jan 2013.
Role of Organic and Inorganic Nanoparticles in the Drug Delivery System for Hypertension Treatment: A Systematic Review
CONCLUSION: This review demonstrated the anti-hypertensive effects of some organic and inorganic nanoparticles alone or in combination with the available anti-hypertensives. We found that organic nanoparticles such as PGLA and chitosan can be considered as preferred options in nanomedicine for treating high blood pressure. The results also showed these nanoparticles displayed antihypertensive effects through some mechanisms such as sustained release forms via increasing bioavailability, increasing oral bioavailability and improving oral and non-oral absorption, counteracting excessive superoxide, decreasing blood pressure,...
Source: Current Cardiology Reviews - March 17, 2022 Category: Cardiology Authors: Nasrollah Moradifar Ali Asghar Kiani Atefe Veiskaramian Kimia Karami Source Type: research
Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo
Int J Mol Sci. 2022 Jul 26;23(15):8241. doi: 10.3390/ijms23158241.ABSTRACTThe high mortality rate caused by atherosclerosis makes it necessary to constantly search for new and better treatments. In previous reports, chemically modified carbon-coated iron nanoparticles (Fe@C NPs) have been demonstrated a high biocompatibility and promising anti-plaque properties. To further investigate these effects, the interaction of these nanoparticles with the adipose tissue of Wistar rats (in vivo) and human atherosclerotic plaques (ex vivo) was studied. For the in vivo study, cobalt-chromium (CoCr) alloy tubes, which are used for coro...
Source: Atherosclerosis - July 28, 2022 Category: Cardiology Authors: Shamil Akhmedov Sergey Afanasyev Natalia Beshchasna Marina Trusova Ivan Stepanov Mariya Rebenkova Ekaterina Poletykina Yuri Vecherskiy Sergei Tverdokhlebov Evgeny Bolbasov Sascha Balakin Joerg Opitz Anatoly Yermakov Boris Kozlov Source Type: research
Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets
CONCLUSION: In the present study, cRGD-platelet@MnO/MSN@PPARα/LXRα nanoparticles with high safety and the capacity to target vulnerable plaques of AS were successfully established. They showed better performance on MRI images and treatment effects on AS by promoting cholesterol efflux through the regulation of ABCA1. These findings might address the problems of off-target effects and side effects of nanoparticle-mediated drug delivery, which will enhance the efficiency of AS treatment and provide new ideas for the clinical treatment of AS.PMID:36211824 | PMC:PMC9537012 | DOI:10.1155/2022/6006601
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Wei Zhang Zheng Lv Yupeng Zhang Subash C B Gopinath Yi Yuan Deyou Huang Liu Miao Source Type: research
Scavenger Receptor-AI-Targeted Iron Oxide Nanoparticles for In Vivo MRI Detection of Atherosclerotic Lesions.
CONCLUSIONS: Collectively, our data provide several lines of evidence that SR-AI-targeted molecular imaging of USPIO-based contrast agents holds great promise for in situ detection of inflammatory plaques in manifest atherosclerosis.
PMID: 23744990 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 6, 2013 Category: Cardiology Authors: Segers FM, den Adel B, Bot I, van der Graaf LM, van der Veer E, Gonzalez W, Raynal I, de Winther M, Wodzig WK, Poelmann RE, van Berkel TJ, van der Weerd L, Biessen EA Tags: Arterioscler Thromb Vasc Biol Source Type: research
Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype
CONCLUSIONS: Exposure to silica and ferric oxide nanoparticles exerts impact on atherosclerosis development and plaque composition. Pro-atherogenic abilities of silica nanoparticles are associated with activation of pro-inflammatory macrophages.PMID:34953274 | DOI:10.1016/j.ecoenv.2021.113112
Source: Atherosclerosis - December 25, 2021 Category: Cardiology Authors: Kamila Stachyra Anna Wi śniewska Anna Kiepura Katarzyna Ku ś Filip Rolski Klaudia Czepiel Łukasz Chmura Grzegorz Majka Marcin Surmiak Justyna Polaczek Rudi van Eldik Maciej Suski Rafa ł Olszanecki Source Type: research
Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment
J Nanobiotechnology. 2022 Dec 27;20(1):542. doi: 10.1186/s12951-022-01746-6.ABSTRACTSynthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is still a challenging task against the complex intercellular environment. Once synthetic nanoparticles enter the body, they are phagocytosed by immune cells by the immune system. Recently, the cell membrane camouflage strategy has emerged as a novel therapeutic tactic to overcome these issues by utilizing the fundamental properties of natural cells. Macrophage, a type of immune system cells, plays ...
Source: Atherosclerosis - December 27, 2022 Category: Cardiology Authors: Yuesong Wu Shengli Wan Shuo Yang Haiyang Hu Chunxiang Zhang Jia Lai Jiahan Zhou Wang Chen Xiaoqin Tang Jiesi Luo Xiaogang Zhou Lu Yu Long Wang Anguo Wu Qingze Fan Jianming Wu Source Type: research
Mapping research performance and hotspots on nanoparticles in cardiovascular diseases
This study aimed to comprehensively summarize the global scientific achievements of nanoparticles in cardiovascular diseases research. Articles on the application of nanoparticles in cardiovascular diseases published from 2002 to 2021 were retrieved from the science citation index expanded of the Web of Science Core Collection, and knowledge maps were generated by Cite Space, VOS viewer, and Hist Cite for further bibliometric analysis. A total of 4321 records were retrieved, and only reviews and articles were retained with a total of 4258 studies. The number of publications on nanoparticles in the cardiovascular field has ...
Source: Atherosclerosis - April 14, 2023 Category: Cardiology Authors: Dan Yin Mi Li Ping Xiang Source Type: research
Effect of polymer nanoparticles on atherosclerotic lesions and the associated mechanisms: a review
Sheng Wu Gong Cheng Xue Bao. 2023 Apr 25;39(4):1390-1402. doi: 10.13345/j.cjb.220522.ABSTRACTPolymer nanoparticles generally refer to hydrophobic polymers-based nanoparticles, which have been extensively studied in the nanomedicine field due to their good biocompatibility, efficient long-circulation characteristics, and superior metabolic discharge patterns over other nanoparticles. Existing studies have proved that polymer nanoparticles possess unique advantages in the diagnosis and treatment of cardiovascular diseases, and have been transformed from basic researches to clinical applications, especially in the diagnosis a...
Source: Atherosclerosis - May 8, 2023 Category: Cardiology Authors: Hang Zou Yan Long Yuzhen Ren Tieying Yin Source Type: research
Chitosan Nanoparticles in Atherosclerosis-Development to Preclinical Testing
Pharmaceutics. 2022 Apr 25;14(5):935. doi: 10.3390/pharmaceutics14050935.ABSTRACTChitosan is a natural biopolymer that is present in an abundant supply in sources such as crustacean shells, mushrooms, and insect exoskeletons. It can be used to make a variety of types of drug formulations and is generally safe to use in vivo; plus, it has inherent cholesterol-reducing properties. While an abundance of papers has tested this biopolymer in nanoparticles in cancer and diabetes research, there is a lag of usage, and hence the paucity of information, in the area of cardiovascular research, specifically in atherosclerosis, the to...
Source: Atherosclerosis - May 28, 2022 Category: Cardiology Authors: Pornsak Sriamornsak Crispin R Dass Source Type: research
Folic acid-decorated PEGylated magnetite nanoparticles as efficient drug carriers to tumor cells overexpressing folic acid receptor
In conclusion, the FA-functionalized magnetic systems can ensure a better internalization of the nanoparticles and can be used to deliver various therapeutic agents, both in cancer treatment and also in the treatment of other inflammation-associated diseases such as rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, Crohn's disease or atherosclerosis.PMID:35952802 | DOI:10.1016/j.ijpharm.2022.122064
Source: Atherosclerosis - August 11, 2022 Category: Cardiology Authors: Codina Movileanu Maria Anghelache Mihaela Turtoi Geanina Voicu Ionela Andreea Neacsu Denisa Ficai Roxana Trusca Ovidiu Oprea Anton Ficai Ecaterina Andronescu Manuela Calin Source Type: research
Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
Autophagy. 2022 Aug 18:1-18. doi: 10.1080/15548627.2022.2108252. Online ahead of print.ABSTRACTDysfunction in the macrophage lysosomal system including reduced acidity and diminished degradative capacity is a hallmark of atherosclerosis, leading to blunted clearance of excess cellular debris and lipids in plaques and contributing to lesion progression. Devising strategies to rescue this macrophage lysosomal dysfunction is a novel therapeutic measure. Nanoparticles have emerged as an effective platform to both target specific tissues and serve as drug delivery vehicles. In most cases, administered nanoparticles are taken up...
Source: Atherosclerosis - August 19, 2022 Category: Cardiology Authors: Xiangyu Zhang Santosh Kumar Misra Parikshit Moitra Xiuli Zhang Se-Jin Jeong Jeremiah Stitham Astrid Rodriguez-Velez Arick Park Yu-Sheng Yeh William E Gillanders Daping Fan Abhinav Diwan Jaehyung Cho Slava Epelman Irfan J Lodhi Dipanjan Pan Babak Razani Source Type: research
