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Evaluation of the Response of HOS and Saos-2 Osteosarcoma Cell Lines When Exposed to Different Sizes and Concentrations of Silver Nanoparticles
Biomed Res Int. 2021 Dec 13;2021:5013065. doi: 10.1155/2021/5013065. eCollection 2021.ABSTRACTOsteosarcoma is considered to be a highly malignant tumor affecting primarily long bones. It metastasizes widely, primarily to the lungs, resulting in poor survival rates of between 19 and 30%. Standard treatment consists of surgical removal of the affected site, with neoadjuvant and adjuvant chemotherapy commonly used, with the usual side effects and complications. There is a need for new treatments in this area, and silver nanoparticles (AgNPs) are one potential avenue for exploration. AgNPs have been found to possess antitumor ...
Source: Cell Research - December 23, 2021 Category: Cytology Authors: Konstantinos Michalakis Athina Bakopoulou Eleni Papachristou Dimitra Vasilaki Alexandros Tsouknidas Nikolaos Michailidis Elaine Johnstone Source Type: research
Anti-tumour effects of TRAIL-expressing human placental derived mesenchymal stem cells with curcumin-loaded chitosan nanoparticles in a mice model of triple negative breast cancer.
In this study, placental-derived mesenchymal stem cells (PDMSCs) have been genetically engineered to deliver a soluble form of TRAIL at the tumour site. Curcumin-loaded chitosan nanoparticles were also fabricated to augment the apoptotic effect of TRAIL. The antitumour effects of this combination therapy were studied in vitro and in mouse models of TNBC. Results indicated that simultaneous delivery of curcumin nanoparticles and TRAIL expressing PDMSCs effectively induces apoptosis in tumour cells and significantly inhibits tumour growth in vivo. This modality may provide new cues for developing new treatment strategies for...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 25, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Long-term tracing and staining of carbon nanoparticles for axillary lymph node in patients with local advanced breast cancer treated with neoadjuvant chemotherapy
CONCLUSION: The regression of positive nodes follows the rule from upper to under, inner to outer in the patients with sensitive consequence to NAC. Long-term staining and tracing by CNs might provide an acceptable and feasible technique to investigate the regression of positive nodes, and would be a potential method for NAC-treated patients by using of ICBN.TRIAL REGISTRATION: NCT03355261. Retrospectively registered on November 28, 2017.PMID:33926797 | DOI:10.1016/j.asjsur.2021.03.020
Source: Asian Journal of Surgery - April 30, 2021 Category: Surgery Authors: Jianyi Li Shi Jia Yitong Wang Yang Zhang Linna Kong Yanan Cao Yushi Liu Yan Zhang Bo Chen Source Type: research
Phytochemical-conjugated bio-safe gold nanoparticles in breast cancer: a comprehensive update
Breast Cancer. 2022 May 16. doi: 10.1007/s12282-022-01368-8. Online ahead of print.ABSTRACTBreast cancer is the most common malignancy in women and is rated among one of the three common malignancies worldwide in combination with colon and lung cancer. The escalating mortality rate of breast cancer patients has captivated the attention of the present-day researchers to come up with new management options. According to WHO, early detection, timely diagnosis and comprehensive breast cancer management are the three cornerstones for controlling breast cancer incidences per year. Multidisciplinary theragnostic approaches for si...
Source: Breast Cancer - May 16, 2022 Category: Cancer & Oncology Authors: Partha Roy Srija Sur Suvadra Das Wong Tin Wui Source Type: research
Tracking Nonpalpable Breast Cancer for Breast-conserving Surgery With Carbon Nanoparticles: Implication in Tumor Location and Lymph Node Dissection
Abstract: To examine the feasibility of using carbon nanoparticles to track nonpalpable breast cancer for breast-conserving surgery.
During breast-conserving surgery, it is often very challenging to determine the boundary of tumor and identify involved lymph nodes. Currently used methods are useful in identifying tumor location, but do not provide direct visual guidance for resection margin during surgery.
The study was approved by the Institutional Review Board of the Fuzhou General Hospital (Fuzhou, China). The current retrospective analysis included 16 patients with nonpalpable breast cancer receiving breast-conserving ...
Source: Medicine - March 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research
Preoperative Submucosal Injection of Carbon Nanoparticles Improves Lymph Node Staging Accuracy in Rectal Cancer after Neoadjuvant Chemoradiotherapy
To evaluate the association between the number of nodes harvested and the rate of node positivity, and to evaluate the effect of carbon nanoparticles (CNPs) in improving lymph node detection and staging accuracy in patients who received neoadjuvant chemoradiotherapy (NCRT) followed by curative resection.
Source: Journal of the American College of Surgeons - August 19, 2015 Category: Surgery Authors: Yanan Wang, Haijun Deng, Hongyuan Chen, Hao Liu, Qi Xue, Jun Yan, Guoxin Li Tags: Original Scientific Article Source Type: research
Intratumorally Injected 177Lu-Labeled Gold Nanoparticles: Gold Nanoseed Brachytherapy with Application for Neoadjuvant Treatment of Locally Advanced Breast Cancer
Conclusion: Gold nanoseeds injected intratumorally were highly effective for inhibiting the growth of breast cancer tumors in CD-1 athymic mice and caused no normal organ toxicity. These results are promising for their application for neoadjuvant brachytherapy of LABC. Because EGFR targeting was not required, the approach is broadly applicable to LABC with different phenotypes.
Source: Journal of Nuclear Medicine - May 31, 2016 Category: Nuclear Medicine Authors: Yook, S., Cai, Z., Lu, Y., Winnik, M. A., Pignol, J.-P., Reilly, R. M. Tags: Basic Science Investigations Source Type: research
Abstract B47: Silver nanoparticles exhibit subtype specific cytotoxic and therapeutic effects in claudin low breast cancer in vitro and in vivo
Triple negative breast cancers (TNBC) are characterized by loss of expression of hormone receptors and decreased expression of the human epidermal growth factor receptor 2 (HER2). TNBC patients do not benefit from current targeted breast cancer (BC) treatments. Molecular profiling of breast cancer has found that TNBC is largely comprised of basal-like and claudin-low intrinsic molecular subtypes. Claudin-low breast cancer (CLBC) accounts for approximately one third of TNBCs, and early evidence suggests CLBC tumors may be more resistant to neoadjuvant anthracycline/taxane-based chemotherapy compared to basal-like tumors. Fo...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Jessica L. Swanner, Iliana Tenvooren, Brian W. Bernish, Cale D. Fahrenholtz, Pierre A. Vidi, Katherine L. Cook, Ravi N. Singh Tags: Drug Delivery and Nanomedicine Source Type: research
Surface engineering of nanoparticles with ligands for targeted delivery to osteosarcoma.
In this study, we investigate and summarize the most common ligands used in the latest NTDDS for osteosarcoma. It might provide new insights into nanomedicine for osteosarcoma treatment.
PMID: 32114271 [PubMed - as supplied by publisher]
Source: Colloids and Surfaces - February 20, 2020 Category: Biotechnology Authors: Huang X, Wu W, Yang W, Qing X, Shao Z Tags: Colloids Surf B Biointerfaces Source Type: research
Cancers, Vol. 15, Pages 2365: Clinical Significance of ABCG2/BCRP Quantified by Fluorescent Nanoparticles in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
In conclusion, high BCRP levels may be associated with poor prognosis in patients with breast cancer, having residual tumors within the primary tumor and lymph nodes after preoperative chemotherapy. These findings provide a basis for further appropriate adjuvant therapy in these patients.
Source: Cancers - April 18, 2023 Category: Cancer & Oncology Authors: Hiroshi Tada Kohsuke Gonda Narufumi Kitamura Takanori Ishida Tags: Article Source Type: research
Carbon nanoparticles localized clipped node dissection combined with sentinel lymph node biopsy with indocyanine green and methylene blue after neoadjuvant therapy in node positive breast cancer in China: initial results of a prospective study
This study aimed to evaluate the feasibility of applying carbon nanoparticles (CNs) to visualize clip-marked metastatic nodes in combination with indocyanine green (ICG) and methylene blue (MB) as sentinel lym...
Source: World Journal of Surgical Oncology - July 21, 2023 Category: Cancer & Oncology Authors: Xin Yang, Yao Li, Xiao-tian Ren, Lei Fan and Bin Hua Tags: Research Source Type: research
Immune Checkpoint Inhibitors in Triple Negative Breast Cancer: The Search for the Optimal Biomarker
Biomark Insights. 2022 Feb 22;17:11772719221078774. doi: 10.1177/11772719221078774. eCollection 2022.ABSTRACTTriple negative breast cancer (TNBC) is a high-risk and aggressive malignancy characterized by the absence of estrogen receptors (ER) and progesterone receptors (PR) on the surface of malignant cells, and by the lack of overexpression of human epidermal growth factor 2 (HER2). It has limited therapeutic options compared to other subtypes of breast cancer. There is now a growing body of evidence on the role of immunotherapy in TNBC, however much of the data from clinical trials is conflicting and thus, challenging fo...
Source: Biomarker Insights - February 28, 2022 Category: General Medicine Authors: Sadaf Qureshi Nancy Chan Mridula George Shridar Ganesan Deborah Toppmeyer Coral Omene Source Type: research
