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Therapy: Immunotherapy
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Total 30422 results found since Jan 2013.
Immunomodulatory roles of selenium nanoparticles: Novel arts for potential immunotherapy strategy development
Front Immunol. 2022 Jul 26;13:956181. doi: 10.3389/fimmu.2022.956181. eCollection 2022.ABSTRACTCurrent chemotherapy strategies used in clinic appear with lots of disadvantages due to the low targeting effects of drugs and strong side effects, which significantly restricts the drug potency, causes multiple dysfunctions in the body, and even drives the emergence of diseases. Immunotherapy has been proved to boost the body's innate and adaptive defenses for more effective disease control and treatment. As a trace element, selenium plays vital roles in human health by regulating the antioxidant defense, enzyme activity, and im...
Source: Cancer Control - August 12, 2022 Category: Cancer & Oncology Authors: Gengshi Chen Fen Yang Shuhao Fan Hua Jin Kangsheng Liao Xuemeng Li Gan-Bin Liu Jing Liang Junai Zhang Jun-Fa Xu Jiang Pi Source Type: research
Sialic Acid-Targeted Cyclodextrin-Based Nanoparticles Deliver CSF-1R siRNA and Reprogram Tumour-Associated Macrophages for Immunotherapy of Prostate Cancer
Eur J Pharm Sci. 2023 Mar 20:106427. doi: 10.1016/j.ejps.2023.106427. Online ahead of print.ABSTRACTProstate cancer remains a serious condition threatening the health of men. Due to the complicated nature of the tumour microenvironment (TME), conventional treatments face challenges including poor prognosis and tumour resistance, therefore new therapeutic strategies are urgently needed. Small interfering RNA (siRNA), a double-stranded non-coding RNA, regulates specific gene expression through RNA interference. Tumour-associated macrophages (TAMs) are a potential therapeutic target in cancer immunotherapy. Colony stimulating...
Source: European Journal of Pharmaceutical Sciences - March 22, 2023 Category: Drugs & Pharmacology Authors: Yao Sun Michael F Cronin Monique C P Mendon ça Jianfeng Guo Caitriona M O'Driscoll Source Type: research
Sialic acid-targeted cyclodextrin-based nanoparticles deliver CSF-1R siRNA and reprogram tumour-associated macrophages for immunotherapy of prostate cancer
Eur J Pharm Sci. 2023 Mar 21;185:106427. doi: 10.1016/j.ejps.2023.106427. Online ahead of print.ABSTRACTProstate cancer remains a serious condition threatening the health of men. Due to the complicated nature of the tumour microenvironment (TME), conventional treatments face challenges including poor prognosis and tumour resistance, therefore new therapeutic strategies are urgently needed. Small interfering RNA (siRNA), a double-stranded non-coding RNA, regulates specific gene expression through RNA interference. Tumour-associated macrophages (TAMs) are a potential therapeutic target in cancer immunotherapy. Colony stimula...
Source: European Journal of Pharmaceutical Sciences - March 22, 2023 Category: Drugs & Pharmacology Authors: Yao Sun Michael F Cronin Monique C P Mendon ça Jianfeng Guo Caitriona M O'Driscoll Source Type: research
Mannosylated polylactic-co-glycolic acid (MN-PLGA) nanoparticles induce potent anti-tumor immunity in murine model of breast cancer
Biomed Pharmacother. 2021 Aug 4;142:111962. doi: 10.1016/j.biopha.2021.111962. Online ahead of print.ABSTRACTNanoparticle-based cancer immunotherapy is considered a novel and promising therapeutic strategy aimed at stimulating host immune responses against tumors. To this end, in the present study, mannan-decorated polylactic-co-glycolic acid (PLGA) nanoparticles containing tumor cell lysate (TCL) and poly riboinosinic polycytidylic acid (poly I:C) were used as antigen delivery systems to immunize breast tumor-bearing Balb/c mice. PLGA nanoparticles were fabricated employing a double emulsion solvent evaporation method. Th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2021 Category: Drugs & Pharmacology Authors: Sanaz Sheikhzadeh Nowruz Delirezh Rahim Hobbenaghi Source Type: research
Conjugation of Silver Nanoparticles with De Novo Engineered Cationic Antimicrobial Peptides: An Exploratory Proposal
CONCLUSIONS: The addition of silver nanoparticles to already developing de novo engineered antimicrobial peptides provide a second degree of freedom toward the development of potent antimicrobials. Future prospects include emergency last line therapy, treatment for current difficult to eradicate bacterial colonization such as in cystic fibrosis, implantable medical devices, cancer and immunotherapy. This proposal is intended to be provided to the public as I do not anticipate funding at this time.PMID:34780345 | DOI:10.2196/28307
Source: Cell Research - November 15, 2021 Category: Cytology Authors: Alvin Hu Source Type: research
Nanoparticles for generating antigen-specific T cells for immunotherapy
Semin Immunol. 2021 Dec 15:101541. doi: 10.1016/j.smim.2021.101541. Online ahead of print.ABSTRACTT cell therapy shows promise as an immunotherapy in both immunostimulatory and immunosuppressive applications. However, the forms of T cell-based therapy that are currently in the clinic, such as adoptive cell transfer and vaccines, are limited by cost, time-to-treatment, and patient variability. Nanoparticles offer a modular, universal platform to improve the efficacy of various T cell therapies as nanoparticle properties can be easily modified for enhanced cell targeting, organ targeting, and cell internalization. Nanopartic...
Source: Seminars in Immunology - December 19, 2021 Category: Allergy & Immunology Authors: Savannah E Est-Witte Natalie K Livingston Mary O Omotoso Jordan J Green Jonathan P Schneck Source Type: research
Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer
Acta Pharm Sin B. 2022 Jan;12(1):353-363. doi: 10.1016/j.apsb.2021.06.006. Epub 2021 Jun 15.ABSTRACTNucleic acid drugs are highly applicable for cancer immunotherapy with promising therapeutic effects, while targeting delivery of these drugs to disease lesions remains challenging. Cationic polymeric nanoparticles have paved the way for efficient delivery of nucleic acid drugs, and achieved stimuli-responsive disassembly in tumor microenvironment (TME). However, TME is highly heterogeneous between individuals, and most nanocarriers lack active-control over the release of loaded nucleic acid drugs, which will definitely redu...
Source: Cancer Control - February 7, 2022 Category: Cancer & Oncology Authors: Lei Fang Zitong Zhao Jue Wang Ping Xiao Xiangshi Sun Yaping Ding Pengcheng Zhang Dangge Wang Yaping Li Source Type: research
