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Green Extracts with Metal-Based Nanoparticles for Treating Inflammatory Diseases: A Review
Curr Drug Deliv. 2023 Jun 2. doi: 10.2174/1567201820666230602164325. Online ahead of print.ABSTRACTGlobally, high death rates and poor quality of life are caused mainly by inflammatory diseases. Corticosteroids, which may have systemic side effects and would enhance the risk of infection, are the common forms of therapy. The field of nanomedicine has created composite nanoparticles that carry a pharmacological carrier and target ligands for distribution to sites of inflammation with less systemic toxicity. However, their relatively large size often causes systemic clearance. An interesting approach is metal-based nanoparti...
Source: Current Drug Delivery - June 6, 2023 Category: Drugs & Pharmacology Authors: Sonia Singh Khushi Sharma Himanshu Sharma Source Type: research

Novel pentablock copolymer (PLA-PCL-PEG-PCL-PLA) based nanoparticles for controlled drug delivery: Effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles.
Abstract The purpose of this investigation was to design novel pentablock copolymers (polylatide-polycaprolactone-polyethylene glycol- polycaprolactone-polylatide) (PLA-PCL-PEG-PCL-PLA) to prepare nanoparticle formulations which provide continuous delivery of steroids over a longer duration with minimal burst effect. Another purpose was to evaluate the effect of poly (L-lactide) (PLLA) or poly (D, L-lactide) (PDLLA) incorporation on crystallinity of pentablock copolymers and in vitro release profile of triamcinolone acetonide (selected as model drug) from nanoparticles. PLA-PCL-PEG-PCL-PLA copolymers with differen...
Source: Colloid and Polymer Science - May 1, 2013 Category: Biotechnology Authors: Tamboli V, Mishra GP, Mitra AK Tags: Colloid Polym Sci Source Type: research

Bioimaging and pulmonary applications of self-assembled Flt1 peptide-hyaluronic acid conjugate nanoparticles.
Abstract Despite wide exploitation of corticosteroid drugs for the treatment of asthma, the poor therapeutic effect on a neutrophilic subtype of asthma prohibits the full recovery of asthma patients. In this work, dexamethasone (Dexa) was loaded in Flt1 peptide-hyaluronic acid (HA) conjugate nanoparticles to overcome the limitation of corticosteroid resistance for the treatment of neutrophilic pulmonary inflammation. Flt1 peptide-HA conjugates are self-assembled to nanoparticles because of hydrophobic Flt1 peptide conjugated to HA by benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) che...
Source: Biomaterials - August 6, 2013 Category: Materials Science Authors: Kim H, Park HT, Tae YM, Kong WH, Sung DK, Hwang BW, Kim KS, Kim YK, Hahn SK Tags: Biomaterials Source Type: research

Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium.
In conclusion, the nanoparticles showed great potential to control the release and penetration of corticosteroids on the skin and mucus membrane and maximize treatment effectiveness. PMID: 28189623 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 7, 2017 Category: Drugs & Pharmacology Authors: Balzus B, Feleke Sahle F, Hönzke S, Gerecke C, Schumacher F, Hedtrich S, Kleuser B, Bodmeier R Tags: Eur J Pharm Biopharm Source Type: research

Recombinant interleukin-1 receptor antagonist conjugated to superparamagnetic iron oxide nanoparticles for theranostic targeting of experimental glioblastoma.
Abstract Cerebral edema commonly accompanies brain tumors and contributes to neurologic symptoms. The role of the interleukin-1 receptor antagonist conjugated to superparamagnetic iron oxide nanoparticles (SPION-IL-1Ra) was assessed to analyze its anti-edemal effect and its possible application as a negative contrast enhancing agent for magnetic resonance imaging (MRI). Rats with intracranial C6 glioma were intravenously administered at various concentrations of IL-1Ra or SPION-IL-1Ra. Brain peritumoral edema following treatment with receptor antagonist was assessed with high-field MRI. IL-1Ra administered at late...
Source: Neoplasia - January 1, 2015 Category: Cancer & Oncology Authors: Shevtsov MA, Nikolaev BP, Yakovleva LY, Dobrodumov AV, Zhakhov AV, Mikhrina AL, Pitkin E, Parr MA, Rolich VI, Simbircev AS, Ischenko AM Tags: Neoplasia Source Type: research

Targeting COPD with PLGA-Based Nanoparticles: Current Status and Prospects
Biomed Res Int. 2022 Mar 11;2022:5058121. doi: 10.1155/2022/5058121. eCollection 2022.ABSTRACTChronic obstructive pulmonary disease (COPD) is pulmonary emphysema characterized by blockage in the airflow resulting in the long-term breathing problem, hence a major cause of mortality worldwide. Excessive generation of free radicals and the development of chronic inflammation are the major two episodes underlying the pathogenesis of COPD. Currently used drugs targeting these episodes including anti-inflammatory, antioxidants, and corticosteroids are unsafe, require high doses, and pose serious side effects. Nanomaterial-conjug...
Source: Biomed Res - March 21, 2022 Category: Research Authors: Juhi Saxena Monish Bisen Aditya Misra Vijay Kumar Srivastava Sanket Kaushik Arif Jamal Siddiqui Neetu Mishra Abhijeet Singh Anupam Jyoti Source Type: research

Pulmonary myeloid cell uptake of biodegradable nanoparticles conjugated with an anti-fibrotic agent provides a novel strategy for treating chronic allergic airways disease
Biomaterials. 2021 Apr 16;273:120796. doi: 10.1016/j.biomaterials.2021.120796. Online ahead of print.ABSTRACTAsthma (chronic allergic airways disease, AAD) is characterized by airway inflammation (AI), airway remodeling (AWR) and airway hyperresponsiveness (AHR). Current treatments for AAD mainly focus on targeting AI and its contribution AHR, with the use of corticosteroids. However, there are no therapies for the direct treatment of AWR, which can contribute to airway obstruction, AHR and corticosteroid resistance independently of AI. The acute heart failure drug, serelaxin (recombinant human gene-2 relaxin, RLX), has po...
Source: Biomaterials - April 24, 2021 Category: Materials Science Authors: Amlan Chakraborty Anita A Pinar Maggie Lam Jane E Bourke Simon G Royce Cordelia Selomulya Chrishan S Samuel Source Type: research

Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery
J Biomed Mater Res A. 2022 Jan 25. doi: 10.1002/jbm.a.37356. Online ahead of print.ABSTRACTLipid nanoparticles (LNPs) play a crucial role in delivering messenger RNA (mRNA) therapeutics for clinical applications, including COVID-19 mRNA vaccines. While mRNA can be chemically modified to become immune-silent and increase protein expression, LNPs can still trigger innate immune responses and cause inflammation-related adverse effects. Inflammation can in turn suppress mRNA translation and reduce the therapeutic effect. Dexamethasone (Dex) is a widely used anti-inflammatory corticosteroid medication that is structurally simil...
Source: Biomed Res - January 25, 2022 Category: Research Authors: Hanwen Zhang Xuexiang Han Mohamad-Gabriel Alameh Sarah J Shepherd Marshall S Padilla Lulu Xue Kamila Butowska Drew Weissman Michael J Mitchell Source Type: research

Antiangiogenic effect of silicate nanoparticles on corneal neo-vascularisation induced by vascular endothelial growth factor
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Mehrdad Mohammadpour , Mahmoud Jabbarvand , Elham Delrish , Ahad Khoshzaban Corneal neo-vascularisation (NV) is a major sight-threatening condition and is caused by infections, degenerative disorders, inflammation and long-time contact lens wear. Corneal NV occurs when the balance between angiogenic and antiangiogenic factors is tipped towards angiogenic molecules. The abnormal vessels may decrease corneal clarity and vision, lead to inflammation and corneal scarring and worsen the prognosis of penetrating keratopl...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Nanoparticles permeate lungs to deliver pulmonary drugs
Researchers from Johns Hopkins University have developed nanoparticles that can shuttle chemicals through the thick mucus membranes of pulmonary airways to deliver drugs. The team’s work was published in the journal Science Advances.  Traditional therapies for cystic fibrosis, COPD and asthma include inhaled corticosteroids that adhere to the walls of air passages. Thick mucus tends to build up inside such passageways, creating a challenge for any delivery system. Get the full story at our sister site, Drug Delivery Business News. The post Nanoparticles permeate lungs to deliver pulmonary drugs appeared first on MassDevice.
Source: Mass Device - April 11, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Pharmaceuticals Research & Development Respiratory Johns Hopkins Source Type: news

Bilirubin nanoparticles ameliorate allergic lung inflammation in a mouse model of asthma.
Abstract Although asthma, a chronic inflammatory airway disease, is relatively well-managed by inhaled corticosteroids, the side effects associated with the long-term use of these agents precipitate the need for alternative therapeutic options based on differing modes of action. Bilirubin, a potent endogenous antioxidant, and anti-inflammatory molecule have been shown to ameliorate asthmatic symptoms; however, its clinical translation has been limited owing to its water insolubility and associated potential toxicity. Here we report the first application of bilirubin-based nanoparticles (BRNPs) as a nanomedicine fo...
Source: Biomaterials - June 12, 2017 Category: Materials Science Authors: Kim DE, Lee Y, Kim M, Lee S, Jon S, Lee SH Tags: Biomaterials Source Type: research

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization
We reported that a single SCT administration of DSP-Zn-NP prevented suture-induced CNV in rats for two weeks. In contrast, the eyes receiving SCT administration of either saline or DSP solution developed extensive CNV in less than 1 week. SCT administration of DSP-Zn-NP could be an effective strategy in preventing and treating CNV.Graphical AbstractDexamethasone sodium phosphate (DSP) was encapsulated into PLGA nanoparticles (DSP-Zn-NP) with dense PEG coatings through a zinc ion chelation following a nanoprecipitation preparation. One single subconjunctival administration of DSP-Zn-NP effectively inhibited the suture-...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 21, 2019 Category: Nanotechnology Source Type: research

Dextran sulfate-triamcinolone acetonide conjugate nanoparticles for targeted treatment of osteoarthritis.
In this study, we reported the design and preparation of dextran sulfate-triamcinolone acetonide conjugate (DS-TA) nanoparticles (NPs) for treating OA by specifically targeting scavenger receptor class A (SR-A) on activated macrophages. We verified the excellent targeting specificity of DS-TA NPs to SR-A by flow cytometry and confocal laser scanning microscopy. DS-TA NPs were found to effectively reduce the viability of activated macrophages (RAW 264.7 cells) and the expression of proinflammatory cytokines. Intra-articular injection of DS-TA NPs effectively alleviated the structural damages to the joint cartilage, as confi...
Source: International Journal of Biological Macromolecules - May 6, 2020 Category: Biochemistry Authors: She P, Bian S, Cheng Y, Dong S, Liu J, Liu W, Xiao C Tags: Int J Biol Macromol Source Type: research