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On RSS Readers, Divorce and Marriage
In just a few days, Google Reader will be history.  I've used it to create over 18,000 Tweets, so yes, I will miss Google Reader.  The end has pushed me into a divorce (or maybe it's just a separation?!) — from Google.  I describe my Google divorce as kind of like when a married couple with children decide to separate … they still have to see their exes for the sake of the kids (and I still have my blogs with Google's Blogger, for now anyway), and it may be a cordial, but not quite blissful separation, but is still necessary.A number of my fellow diabetes blogging peers have already migrated from Google'...
Source: Scott's Web Log - June 28, 2013 Category: Diabetes Authors: Scott S Source Type: blogs

Evaluation of neuropeptide loaded trimethyl chitosan nanoparticles for nose to brain delivery.
Abstract Leucine-enkephalin (Leu-Enk) is a neurotransmitter or neuromodulator in pain transmission. Due to non-addictive opioid analgesic activity of this peptide, it might have great potential in pain management. Leu-Enk loaded N-Trimethyl chitosan (TMC) nanoparticles were prepared and evaluated as a brain delivery vehicle via nasal route. TMC biopolymer was synthesized and analyzed by (1)H NMR spectroscopy. TMC nanoparticles were prepared by ionic gelation method. Mean peptide encapsulation efficiency and loading capacity were 78.28±3.8% and 14±1.3% respectively. Mean particle size, Polydispersity index and ze...
Source: International Journal of Biological Macromolecules - July 2, 2013 Category: Biochemistry Authors: Kumar M, Pandey RS, Patra KC, Jain SK, Soni ML, Dangi JS, Madan J Tags: Int J Biol Macromol Source Type: research

Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice
Publication date: 6 March 2018 Source:Neuroscience Letters, Volume 668 Author(s): Tao Wang, Olivia Hurwitz, Steven G. Shimada, Daofeng Tian, Feng Dai, Jiangbing Zhou, Chao Ma, Robert H. LaMotte Bupivacaine is a commonly used local anesthetic in postoperative pain management. We evaluated the effects of a prolonged, local delivery of bupivacaine on pain behavior accompanying a chronic compression of the dorsal root ganglion (CCD) – an animal model of radicular pain. Poly(lactide-coglycolide) (PLGA) nanoparticles encapsulating bupivacaine were injected unilaterally into the L3 and L4 DRGs of mice just before producing CCD...
Source: Neuroscience Letters - February 4, 2018 Category: Neuroscience Source Type: research

pH-sensitive HPMCP-chitosan nanoparticles containing 5-aminosalicylic acid and berberine for oral colon delivery in a rat model of ulcerative colitis
In conclusion, although 5-ASA/HPMCP/CSNPs showed the best effect in the treatment of UC, BBR/HPMCP/CSNPs, and 5-ASA/BBR/HPMCP/CSNPs were also effective in vivo study, and this study anticipated they could be helpful in future clinical applications for the management of UC.PMID:37302632 | DOI:10.1016/j.ijbiomac.2023.125332
Source: International Journal of Biological Macromolecules - June 11, 2023 Category: Biochemistry Authors: Solmaz Mahami Majid Salehi Mohsen Mehrabi Hamid Vahedi Maryam Sadat Hassani Fatemeh Sadat Bitaraf Abdelwahab Omri Source Type: research

Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Diana Tronino, Alessia Offerta, Carmine Ostacolo, Roberto Russo, Carmen De Caro, Antonio Calignano, Carmelo Puglia, Paolo Blasi N-Palmitoylethanolamide showed great therapeutic potential in the treatment of inflammation and pain but its unfavourable pharmacokinetics properties will hinder its use in the clinical practice. A nanotechnology-based formulation was developed to enhance the probability of N-palmitoylethanolamide therapeutic success, especially in skin disease management. Lipid nanoparticles were produced a...
Source: Colloids and Surfaces B: Biointerfaces - February 12, 2016 Category: Biochemistry Source Type: research

Design, Network Analysis and In Silico Modeling of Biologically Significant 4-(substituted benzyl)-2-Amino-6-HydroxyPyrimidine-5-Carboxamide Nanoparticles
Drug Res (Stuttg) DOI: 10.1055/s-0042-124515 The synthesized 4-(4-hydroxy benzyl)-2-amino-6-hydroxy pyrimidine-5-carboxamide was chosen to perform in silico modeling with identified drug target AGT, TNF, F2 and BCL2L1. The identified human proteins are vital in the pain management and also an important target for the study of wound healing activity. The enzymes were identified by using BioGRID, string database and network analysis through Cytoscape software. The wound healing activity was evaluated by excision wound model. The observed results revealed that, the pyrimidine nanoparticles showed significant wound healing act...
Source: Drug Research - March 6, 2017 Category: Drugs & Pharmacology Authors: Panneerselvam, Theivendren Sivakumar, Vellaichamy Arumugam, Subramanian Selvaraj, Kunjiappan Indhumathy, Murugan Tags: Original Article Source Type: research

Colchicine mesoporous silica nanoparticles/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management.
In this study, novel colchicine transdermal delivery systems were developed to conquer such obstacles. Cellulose-based patches were primed, where mesoporous silica nanoparticles (MSNs) were prepared and used as colchicine encapsulators. The free colchicine or the encapsulated drug was embedded into self-healing hydrogel. The hydrogel was prepared by reacting carboxyethyl chitosan and oxidized pullulan. These composites were used to treat cotton gauze to produce easily applicable and extended-release transdermal patches. Nitrogen adsorption-desorption isotherms, DLS, TEM, and SEM were used to estimate surface area, pore-vol...
Source: International Journal of Biological Macromolecules - July 17, 2020 Category: Biochemistry Authors: Mohamed AL, Elmotasem H, Salama AAA Tags: Int J Biol Macromol Source Type: research

Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes
Drug Discov Today. 2022 Oct 5:103393. doi: 10.1016/j.drudis.2022.103393. Online ahead of print.ABSTRACTCurrently, the only practical way to treat type 1 and advanced insulin-dependent type 2 diabetes mellitus (T1/2DM) is the frequent subcutaneous injection of insulin, which is significantly different physiologically from endogenous insulin secretion from pancreatic islets and can lead to hyperinsulinemia, pain, and infection in patients with poor compliance. Hence, oral insulin delivery has been actively pursued to revolutionize the treatment of insulin-dependent diabetes. In this review, we provide an overview of recent p...
Source: Drug Discovery Today - October 8, 2022 Category: Drugs & Pharmacology Authors: Huiwen Pang Xiangquan Huang Zhi Ping Xu Chen Chen Felicity Y Han Source Type: research

Molecules, Vol. 27, Pages 7312: Chitosan Encapsulated Meloxicam Nanoparticles for Sustained Drug Delivery Applications: Preparation, Characterization and Pharmacokinetics in Wistar Rats
Prasad Ubaradka Meloxicam (MLX) is currently used in the therapeutic management of both acute and chronic inflammatory disorders such as pain, injuries, osteoarthritis, and rheumatoid arthritis in both humans and animals. Gastrointestinal toxicity and occasional renal toxicity were observed in patients taking it for a long-term period. Meloxicam’s late attainment of peak plasma concentration results in a slow onset of action. The goal of the current study was to prepare and characterize chitosan encapsulated meloxicam nanoparticles (CEMNPs) with high bioavailability and less gastro intestinal toxicit...
Source: Molecules - October 27, 2022 Category: Chemistry Authors: Yegireddy Nadoor Rao Hanumanthu Rajashekaraiah Ramachandrappa Halemani Mannem Prasad Ubaradka Tags: Article Source Type: research

Analysis of google trends and search results for ophthalmic symptoms of monkeypox
ConclusionSearch interest in monkeypox ophthalmic symptoms corresponds with geographic and temporal trends, i.e., timing and location of the first reported non-endemic cases and WHO announcement. Although ophthalmic symptoms are not as widely searched currently, inclusion in public health messaging is key for diagnosis, appropriate management, and reduction of further transmission.
Source: International Ophthalmology - April 18, 2023 Category: Opthalmology Source Type: research

Protein-Functionalized PLGA Nanoparticles of Lamotrigine for Neuropathic Pain Management.
Abstract Lamotrigine (LTG), a sodium and calcium channel blocker, has demonstrated efficacy for the treatment of neuropathic pain in multiple, randomized, controlled trials. However, its potential clinical applications in neuropathic pain are limited due to the risk of dose-dependent severe rashes associated with high dose and prompt dose escalation. Further, the poor pharmacokinetic profile due to non-selective distribution to organs other than brain reduces the efficacy of dosage regimen. Therefore, the aim of present investigation is to develop surface-engineered LTG nanoparticles (NPs) using transferrin and la...
Source: AAPS PharmSciTech - October 30, 2014 Category: Drugs & Pharmacology Authors: Lalani J, Patil S, Kolate A, Lalani R, Misra A Tags: AAPS PharmSciTech Source Type: research

Molecules, Vol. 21, Pages 774: Synthesis of Silver Nanoparticles Using Buchu Plant Extracts and Their Analgesic Properties
We herein report for the first time the synthesis and analgesic properties of silver nanoparticles (Ag-NPs) using buchu plant extract. The as-synthesised Ag-NPs at different temperatures were characterised by UV-Vis spectroscopy, Fourier transform infra-red spectroscopy (FTIR) and transmission transform microscopy (TEM) to confirm the formation of silver nanoparticles. Phytochemical screening of the ethanolic extract revealed the presence of glycosides, proteins, tannins, alkaloids, flavonoids and saponins. The absorption spectra showed that the synthesis is temperature and time dependent. The TEM analysis showed that the ...
Source: Molecules - June 13, 2016 Category: Chemistry Authors: Herbert ChiguvareOpeoluwa OyedejiReuben MatewuOlukayode AremuIdris OyemitanAdebola OyedejiBenedicta Nkeh-ChungagSandile SongcaSneha MohanOluwatobi Oluwafemi Tags: Article Source Type: research

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug.
Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities. PMID: 30642012 [PubMed - in process]
Source: Medicina (Kaunas) - January 11, 2019 Category: Universities & Medical Training Authors: Kiyani MM, Sohail MF, Shahnaz G, Rehman H, Akhtar MF, Nawaz I, Mahmood T, Manzoor M, Bokhari SAI Tags: Medicina (Kaunas) Source Type: research