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Total 1183 results found since Jan 2013.

Self-Assembled Ferritin Nanoparticles Expressing Hemagglutinin as an Influenza Vaccine
NIH inventors at the Vaccine Research Center have developed a novel influenza virus hemagglutinin (HA)-ferritin nanoparticle influenza vaccine that is easily manufactured, potent, and elicits broadly neutralizing influenza antibodies against multiple strains of influenza. This novel influenza nanoparticle vaccine elicited two types of broadly neutralizing, cross-protective antibodies, one directed to the highly conserved HA stem and a second proximal to the conserved receptor binding site (RBS) of the viral HA, providing a new platform for universal and seasonal influenza. In addition, HA-ferritin nanoparticles can be easi...
Source: NIH OTT Licensing Opportunities - July 20, 2012 Category: Research Authors: admin Source Type: research

Protein Nanoparticles for Antigen Display in Vaccines
The technology relates to a protein-based nanoparticle platform that allows presentation of immunogenic molecules such as influenza virus antigens. This protein platform is made up of hepatitis B capsid/core proteins. The core proteins contain immunogenic loop c/e1, where other antigens can be inserted and the chimeric protein retains the ability to form capsid-like particles. The technology describes the insertion of one or more copies of influenza epitopes derived from the globular head or the stem region of hemagglutinin protein into or around the c/e1 loop of the core protein. The nanoparticles formed by the use of Hep...
Source: NIH OTT Licensing Opportunities - March 9, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Nanoparticles and Its Implications in HIV/AIDS Therapy.
Abstract The use of antiretroviral drugs to treat HIV/AIDS patients has enormously increased their life spans with serious disadvantages. The virus infection still remains a public health problem worldwide with no cure and vaccine for the viral agent until now. The use of nanoparticles (NPs) for the prevention and treatment of HIV/AIDS is an emerging technology of the 21st century. NPs are solid, colloidal particles with size range from 10 nm to <1000 nm; however, for nanomedical application, the preferential size is less than 200 nm. There are NPs with therapeutic capabilities such as liposomes, micelles...
Source: Current Drug Discovery Technologies - June 19, 2019 Category: Drugs & Pharmacology Authors: Victor OB Tags: Curr Drug Discov Technol Source Type: research

Protein Nanoparticles for Antigen Display in Vaccines
The technology relates to a protein-based nanoparticle platform that allows presentation of immunogenic molecules such as influenza virus antigens. This protein platform is made up of hepatitis B capsid/core proteins. The core proteins contain immunogenic loop c/e1, where other antigens can be inserted and the chimeric protein retains the ability to form capsid-like particles. The technology describes the insertion of one or more copies of influenza epitopes derived from the globular head or the stem region of hemagglutinin protein into or around the c/e1 loop of the core protein. The nanoparticles formed by the use of Hep...
Source: NIH OTT Licensing Opportunities - July 6, 2020 Category: Research Authors: ott-admin Source Type: research

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.
Abstract A major step toward an HIV-1 vaccine is an immunogen capable of inducing neutralizing antibodies. Envelope glycoprotein (Env) mimetics, such as the NFL and SOSIP designs, generate native-like, well-ordered trimers and elicit tier 2 homologous neutralization (SOSIPs). We reasoned that the display of well-ordered trimers by high-density, particulate array would increase B cell activation compared to soluble trimers. Here, we present the design of liposomal nanoparticles displaying well-ordered Env spike trimers on their surface. Biophysical analysis, cryo- and negative stain electron microscopy, as well as ...
Source: IAVI Rep - May 17, 2016 Category: Infectious Diseases Authors: Ingale J, Stano A, Guenaga J, Sharma SK, Nemazee D, Zwick MB, Wyatt RT Tags: Cell Rep Source Type: research

The Holy Grail: The Search for Undiagnosed Cases Is Paramount in Improving the Cascade of Care Among People Living With HIV.
Abstract Highly Active Antiretroviral Therapy (HAART) has transformed the nature of HIV/AIDS from an imminent death sentence to a chronic manageable condition. There is a growing interest in the potential impact of "treatment as prevention" - a notion that expanded coverage with HAART would substantially reduce morbidity and mortality from HIV, and secondarily HIV transmission at the population level. However, undiagnosed and undocumented HIV cases cannot benefit from HAART and are more likely to experience HIV-related morbidity and untimely mortality. Late diagnosis of HIV remains prevalent and represents missed ...
Source: Canadian Journal of Public Health - November 8, 2013 Category: Global & Universal Authors: Eyawo O, Hogg RS, Montaner JS Tags: Can J Public Health Source Type: research

Africa: The Search for an Effective HIV Vaccine Continues
[The Conversation Africa] An HIV vaccine trial that started in 2016 in South Africa was halted in February 2020. The study sponsors made the call after interim results showed that the vaccine, known as HVTN 702, did not prevent HIV. This result was disappointing, but the search for an effective HIV vaccine continues. Anatoli Kamali speaks to The Conversation Africa's Ina Skosana about other developments in the field.
Source: AllAfrica News: HIV-Aids and STDs - February 17, 2020 Category: Infectious Diseases Source Type: news

The search for an HIV vaccine, the journey continues.
Authors: Dieffenbach CW, Fauci AS PMID: 32418357 [PubMed - in process]
Source: Journal of the International AIDS Society - May 19, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks. Sedentary Behavior Raises the Risk of Cancer Mortality https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/ Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a re...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/ Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medici...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms
Purpose of review We will discuss recent advances in the development of nanoparticle vaccines presenting HIV-1 envelope trimer vaccines and the immunological mechanisms by which they act. Recent findings The multivalent presentation of Env trimers on nanoparticles is a promising strategy to increase Env immunogenicity. Recent studies have shed light on how Env nanoparticles increase lymph node trafficking and germinal center formation by using the lectin-mediated complement pathway and enhancing the interaction with naïve B cells. Meanwhile, research on different nanoparticle platforms has resulted in improved design...
Source: Current Opinion in HIV and AIDS - June 3, 2019 Category: Infectious Diseases Tags: BROAD NEUTRALISING AND NON-NEUTRALISING ANTIBODIES: Edited by Hugo Mouquet and Olivier Schwartz Source Type: research

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Top 10 Online Medical Resources For The Patients Of The Future
There are over 1 billion health-related searches on Google every single day, according to a report. This was about 7% of all searches on the platform before, and no one will be surprised when the 2020 data massively surpasses this number. After all, the internet is likely the first source to turn to with your health-related questions. But which hits are relevant, and which lead to straightforward la la land – even with the best intentions and the best A.I. toolset, the search giant can’t exclude the latter from among the results. And yet, doing so is especially important in the case of medicine and healthcare, s...
Source: The Medical Futurist - December 10, 2020 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research E-Patients Medical Education Medicine social media Webicina webmd gc2 online resources pharmaceutics Topol Mayo Clinic ePatients Medscape Eric Topol Smart Patients Medline Plus National Library of Source Type: blogs

Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens
Cell Rep. 2022 Jan 11;38(2):110217. doi: 10.1016/j.celrep.2021.110217.ABSTRACTNanoparticle (NP) vaccine formulations promote immune responses through multiple mechanisms. We recently reported that mannose-binding lectin (MBL) triggers trafficking of glycosylated HIV Env-immunogen NPs to lymph node follicles. Here, we investigate effects of MBL and complement on NP forms of HIV and other viral antigens. MBL recognition of oligomannose on gp120 nanoparticles significantly increases antigen accumulation in lymph nodes and antigen-specific germinal center (GC) responses. MBL and complement also mediate follicular trafficking a...
Source: IAVI Rep - January 12, 2022 Category: Infectious Diseases Authors: Benjamin J Read Lori Won John C Kraft Isaac Sappington Aereas Aung Shengwei Wu Julia Bals Chengbo Chen Kelly K Lee Daniel Lingwood Neil P King Darrell J Irvine Source Type: research