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Vaccination: Malaria Vaccine

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Total 1540 results found since Jan 2013.

Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles.
Abstract Malaria transmission-blocking vaccines (TBV) targeting sexual stages of the parasite represent an ideal intervention to reduce the burden of the disease and eventual elimination at the population level in endemic regions. Immune responses against sexual stage antigens impair the development of parasite inside the mosquitoes. Target antigens identified in Plasmodium falciparum include surface proteins Pfs230 and Pfs48/45 in male and female gametocytes and Pfs25 expressed in zygotes and ookinetes. The latter has undergone extensive evaluation in pre-clinical and phase I clinical trials and remains one of th...
Source: Vaccine - August 20, 2015 Category: Allergy & Immunology Authors: Kumar R, Ray PC, Datta D, Bansal GP, Angov E, Kumar N Tags: Vaccine Source Type: research

Molecules, Vol. 27, Pages 8677: Polylactide Nanoparticles as a Biodegradable Vaccine Adjuvant: A Study on Safety, Protective Immunity and Efficacy against Human Leishmaniasis Caused by Leishmania Major
Mohamed Elayeb Leishmaniasis is the 3rd most challenging vector-borne disease after malaria and lymphatic filariasis. Currently, no vaccine candidate is approved or marketed against leishmaniasis due to difficulties in eliciting broad immune responses when using sub-unit vaccines. The aim of this work was the design of a particulate sub-unit vaccine for vaccination against leishmaniasis. The poly (D,L-lactide) nanoparticles (PLA-NPs) were developed in order to efficiently adsorb a recombinant L. major histone H2B (L. major H2B) and to boost its immunogenicity. Firstly, a study was focused on the production of well-for...
Source: Molecules - December 8, 2022 Category: Chemistry Authors: Sana Ayari-Riabi Noureddine Ben khalaf Balkiss Bouhaouala-Zahar Bernard Verrier Thomas Trimaille Zakaria Benlasfar Mehdi Chenik Mohamed Elayeb Tags: Article Source Type: research

Optimizing the design of protein nanoparticles as carriers for vaccine applications
Publication date: Available online 4 June 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Tais A.P.F. Doll , Tobias Neef , Nha Duong , David E. Lanar , Philippe Ringler , Shirley A. Müller , Peter Burkhard Successful vaccine development remains a huge challenge for infectious diseases such as malaria, HIV and influenza. As a novel way to present antigenic epitopes to the immune system, we have developed icosahedral self-assembling protein nanoparticles (SAPNs) to serve as a prototypical vaccine platform for infectious diseases. Here we examine some biophysical factors that affect the self-assem...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 5, 2015 Category: Nanotechnology Source Type: research

Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles
Conclusion Results suggest that CHrPfs25 delivered in various adjuvants / nanoparticles elicited strong functional immunogenicity in pre-clinical studies in mice. We are now continuing these studies to develop effective vaccine formulations for further evaluation of immune correlates of relative immunogenicity of CHrPfs25 in various adjuvants and clinical trials.
Source: Pharmaceutical Research - November 4, 2015 Category: Drugs & Pharmacology Source Type: research

Nanoparticles modify dendritic cell homeostasis and induce non-specific effects on immunity to malaria
Conclusions Intradermal administration of 40 nm PSNPs modifies DC homeostasis, which may at least in part explain the observed beneficial heterologous effects of current particulate vaccines. Further nanotechnological developments may exploit such strategies to promote beneficial non-specific effects.
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - January 8, 2015 Category: Tropical Medicine Authors: Xiang, S. D., Kong, Y. Y., Hanley, J., Fuchsberger, M., Crimeen-Irwin, B., Plebanski, M. Tags: ORIGINAL ARTICLES Source Type: research

Optimizing the design of protein nanoparticles as carriers for vaccine applications
Successful vaccine development remains a huge challenge for infectious diseases such as malaria, HIV and influenza. As a novel way to present antigenic epitopes to the immune system, we have developed icosahedral self-assembling protein nanoparticles (SAPNs) to serve as a prototypical vaccine platform for infectious diseases. Here we examine some biophysical factors that affect the self-assembly of these nanoparticles, which have as basic building blocks coiled-coil oligomerization domains joined by a short linker region.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - June 4, 2015 Category: Nanotechnology Authors: Tais A.P.F. Doll, Tobias Neef, Nha Duong, David E. Lanar, Philippe Ringler, Shirley A. Müller, Peter Burkhard Source Type: research

Gold nanoparticles - against parasites and insect vectors.
Abstract Nanomaterials are currently considered for many biological, biomedical and environmental purposes, due to their outstanding physical and chemical properties. The synthesis of gold nanoparticles (Au NPs) is of high interest for research in parasitology and entomology, since these nanomaterials showed promising applications, ranging from detection techniques to drug development, against a rather wide range of parasites of public health relevance, as well as on insect vectors. Here, I review current knowledge about the bioactivity of Au NPs on selected insect species of public health relevance, including maj...
Source: Acta Tropica - October 29, 2017 Category: Infectious Diseases Authors: Benelli G Tags: Acta Trop Source Type: research

WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships
Publication date: Available online 19 September 2014 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Roopa Ramamoorthi , Katy M. Graef , Jennifer Dent Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of new drugs, vaccines, and diagnostics for these diseases by connecting the assets and resources of pharmaceutical companies, such as compound libraries and expertise, to academic or nonprofit researchers w...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 12, 2014 Category: Parasitology Source Type: research

Immunogenicity and protective potential of a Plasmodium spp. enolase peptide displayed on archaeal gas vesicle nanoparticles
Having identified Plasmodium enolase as a potential protective vaccine antigen in a previous study, the authors have cloned the DNA sequence encoding a 10 AA peptide of this enolase and expressed it in nanoparticles from Halobacterium. This construct was used to immunize mice.
Source: Malaria Journal - October 14, 2015 Category: Infectious Diseases Authors: Sneha DuttaPriya DasSarmaShiladitya DasSarmaGotam Jarori Source Type: research

Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets.
Abstract Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is currently limited to a single drug, Praziquantel, which is quite effective with a single-day treatment and virtually no host-toxicity. Recently, however, the ...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - July 20, 2017 Category: Biochemistry Authors: El Kouni MH Tags: Comp Biochem Physiol B Biochem Mol Biol Source Type: research

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - September 22, 2021 Category: Drugs & Pharmacology Source Type: research

Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles
Recent studies have suggested that CD8+ liver-resident memory T (TRM) cells are crucial in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) to induce liver TRM cells in a murine model. Single-dose intravenous injections of ovalbumin mRNA-LNPs effectively induced antigen-specific cytotoxic T lymphocytes in a dose-dependent manner in the liver on day 7. TRM cells (CD8+ CD44hi CD62Llo CD69+ KLRG1-) were induced 5 weeks after immunization. To examine the protective efficacy, mice were intramuscularly immunized with two doses of circumsporozoite protein mRNA-LNPs...
Source: Frontiers in Immunology - August 23, 2023 Category: Allergy & Immunology Source Type: research

Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.
Abstract Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed ...
Source: Vaccine - February 27, 2014 Category: Allergy & Immunology Authors: Bermúdez A, Calderon D, Moreno-Vranich A, Almonacid H, Patarroyo MA, Poloche A, Patarroyo ME Tags: Vaccine Source Type: research

Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets
Publication date: Available online 21 July 2017 Source:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Author(s): Mahmoud H. el Kouni Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is curren...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - July 21, 2017 Category: Molecular Biology Source Type: research

Rwanda: Rwanda Optimistic About Latest Breakthrough in Search for a Malaria Vaccine
[New Times] Officials at Rwanda Biomedical Centre (RBC) have said they are optimistic about the recent unprecedented developments in the search for a malaria vaccine, and hope soon there will be a vaccine to complement the existing measures to fight the disease.
Source: AllAfrica News: Malaria - April 26, 2021 Category: Infectious Diseases Source Type: news