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Evaluation of Low Molecular Weight Cross Linked Chitosan Nanoparticles, to Enhance the Bioavailability of 5-Flourouracil
Dose Response. 2021 Jul 28;19(2):15593258211025353. doi: 10.1177/15593258211025353. eCollection 2021 Apr-Jun.ABSTRACTThe present study aimed to formulate 5-fluorouracil loaded cross linked chitosan nanoparticles based on chemical cross-linking of low molecular weight chitosan with glutaraldehyde by reverse micelles technique as 5-FU is less hydrophobic, relatively potent, has a shorter half-life, is rapidly metabolized, less tolerated, and has low oral bioavailability; therefore, we aimed to formulate potential nanocarriers of 5-FU for efficient drug delivery to specific targeted areas of action, reduce oral toxicity, impr...
Source: Dose Response - August 11, 2021 Category: Drugs & Pharmacology Authors: Aisha Sethi Mahmood Ahmad Tayyaba Huma Ikrima Khalid Imtiaz Ahmad Source Type: research
Preparation of Modified Chitosan-Based Nanoparticles for Efficient Delivery of Doxorubicin and/or Cisplatin to Breast Cancer Cells
CONCLUSION: These novel pH sensitive nanoparticles proved to be a promising Nano- drug delivery for tumor-targeted delivery of DOX.PMID:35081892 | DOI:10.2174/1568009622666220126100532
Source: Current Cancer Drug Targets - January 27, 2022 Category: Cancer & Oncology Authors: Sina M Matalqah Khalid Aiedeh Nizar M Mhaidat Karem H Alzoubi Belal A Al-Husein Source Type: research
Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism
This study opens a promising way for targeted drug treatment of renal fibrosis.PMID:34529980 | DOI:10.1016/j.ejphar.2021.174501
Source: European Journal of Pharmacology - September 16, 2021 Category: Drugs & Pharmacology Authors: Qixia Liu Xiaohui Chen Min Kan Jing Yang Qian Gong Rui Jin Yulong Dai Juan Jin Hongmei Zang Source Type: research
Preparation of ICA-loaded mPEG-ICA nanoparticles and their application in the treatment of LPS-induced H9c2 cell damage
In conclusion, ICA-loaded mPEG-ICA nanoparticles protected against LPS-induced H9c2 cell injury.PMID:34657986 | DOI:10.1186/s11671-021-03609-9
Source: Cell Research - October 18, 2021 Category: Cytology Authors: Lin Zhou Zhi Huang Shanyi Yang Jiarui Wei Yan Xu Lin Hu Xinrong Guo Limin Yuan Zexuan Yuan Xiaoping Yang Xiaojun Tao Qiufang Zhang Source Type: research
Polymeric nanoparticles containing babassu oil: A proposed drug delivery system for controlled release of hydrophilic compounds
In this study, we developed and characterized particles containing babassu oil, solely or combined with sorbitan monostearate (Span® 60) or medium chain triglycerides (MCT) in the core to test different HLB and evaluated the encapsulation of a model hydrophilic molecule. Different techniques were used to characterize all formulations in terms of size and distribution, and in vitro drug release by dialysis technique was performed. The BBS was also characterized and presented 46,05 ± 1,11% and 15,38 ± 0,06% of lauric and myristic acid, respectively; saponification index of 248.87 ± 0.64 mg of KOH per gram of BBS, and no ...
Source: Chemistry and Physics of Lipids - April 20, 2023 Category: Lipidology Authors: Jo ão Vitor Raupp de Oliveira Pedro Leardin Silveira Gabriela Spingolon Gabriel Antonio Lopes Alves Fl ávia Pires Peña Tanira Alessandra Silveira Aguirre Source Type: research
