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Total 15257 results found since Jan 2013.

Mucopenetrating nanoparticles: vehicles for the oral administration of paclitaxel.
Abstract Paclitaxel is an anticancer drug used as solution for perfusion for the treatment of certain types of cancers. In the last years, a number of strategies have been proposed for the development of an oral formulation of this drug. However, this task is quite complicated due to the poor aqueous solubility of paclitaxel as well as the fact that this compound is substrate of the intestinal P-glycoprotein and the cytochrome P450 enzymatic complex. In this work, we have developed pegylated nanoparticles with mucopenetrating properties in order to conduct paclitaxel onto the surface of the enterocyte. These nanop...
Source: Annales Pharmaceutiques Francaises - March 1, 2013 Category: Drugs & Pharmacology Authors: Zabaleta V, Calleja P, Espuelas S, Corrales L, Pío R, Agüeros M, Irache JM Tags: Ann Pharm Fr Source Type: research

Prevention of Ventilator-Induced Lung Edema by Inhalation of Nanoparticles Releasing Ruthenium Red.
Conclusions: These data offer proof of principle that inhalation of nanoparticles containing a TRPV4 inhibitor prevents ventilator damage for several days, and imply that this novel drug delivery strategy could be used to target alveolar macrophages in patients at risk of VILI prior to initiating mechanical ventilation. PMID: 24405281 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - January 9, 2014 Category: Molecular Biology Authors: Jurek SC, Hirano-Kobayashi M, Chiang H, Kohane DS, Matthews BD Tags: Am J Respir Cell Mol Biol Source Type: research

Inhibition of intimal hyperplasia via local delivery of vascular endothelial growth factor cDNA nanoparticles in a rabbit model of restenosis induced by abdominal aorta balloon injury.
Authors: Xie H, Yang J, Han Y, Zhu X, Fang Q Abstract In-stent restenosis (ISR) is one of the major factors affecting long-term outcomes of percutaneous coronary interventions. Vascular endothelial growth factor (VEGF) has been hypothesized to have a positive role in preventing ISR, however, this remains controversial. The aim of the present study was to assess whether nanoparticles can be used to deliver VEGF to injured arteries and whether this is beneficial in preventing restenosis. New Zealand White rabbits were randomly divided into a control group, an empty nanoparticles group and a VEGF nanoparticles group (...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Induction of Angiogenesis by Controlled Delivery of Vascular Endothelial Growth Factor Using Nanoparticles
ConclusionsDex‐GMA and gelatin‐based nanoparticles could provide sustained release of VEGF and may serve as a new way for angiogenesis.
Source: Cardiovascular Therapeutics - April 17, 2013 Category: Cardiology Authors: Jiaqi Xie, Haibin Wang, Yunya Wang, Fangping Ren, Wei Yi, Kun Zhao, Zilin Li, Qiang Zhao, Zhenhua Liu, Hong Wu, Chunhu Gu, Dinghua Yi Tags: Original Research Article Source Type: research

Bortezomib-loaded solid lipid nanoparticles: preparation, characterization, and intestinal permeability investigation.
Authors: Mahmoudian M, Valizadeh H, Zakeri-Milani P Abstract Bortezomib (BTZ), a proteasome inhibitor, is clinically used for the treatment of multiple myeloma and mantle cell lymphoma via intravenous or subcutaneous administration. Since BTZ has limited intestinal permeability, in this study, solid lipid nanoparticles (SLNs) were selected as lipid carrier to improve the intestinal permeability of BTZ. The nanoparticles were prepared by hot oil-in-water emulsification method and characterized for physicochemical properties. Moreover, in situ single-pass intestinal perfusion technique was used for intestinal permeab...
Source: Drug Development and Industrial Pharmacy - June 9, 2018 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation and Evaluation of Lecithin/Zein Hybrid Nanoparticles for the Oral Delivery of Panax Notoginseng Saponins
Eur J Pharm Sci. 2021 May 14:105882. doi: 10.1016/j.ejps.2021.105882. Online ahead of print.ABSTRACTPanax Notoginseng Saponins (PNS) has been widely used in the prevention and treatment of cardiovascular and cerebrovascular diseases such as myocardial infarction, heart failure and cerebral infarction. However, oral administration of PNS showed low bioavailability because of its instability and poor membrane permeability in the gastrointestinal tract. Here, lipoprotein-inspired hybrid nanoparticles of PNS-Lecithin-Zein (PLZ-NPs) were prepared by using a simple phase separation method, which possessed a core-shell structure,...
Source: European Journal of Pharmaceutical Sciences - May 17, 2021 Category: Drugs & Pharmacology Authors: Wen Fu Yiping Liang Zhonghui Xie Hangyi Wu Zhenhai Zhang Huixia Lv Source Type: research

Sorafenib derivatives-functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR and VEGFR-2
Exp Cell Res. 2021 Jun 2:112633. doi: 10.1016/j.yexcr.2021.112633. Online ahead of print.ABSTRACTIncreasing evidence has reported the great promise of multicomponent and multifunctional nanoparticles as advanced therapies of human diseases, especially tumors. In the current study, we investigated the functionality of new sorafenib derivatives-capped gold nanoparticles (AuNPs-New Sor) in tumor growth as well as their anti-tumor mechanisms. Initially, new sorafenib derivatives were constructed and combined with AuNPs to form AuNPs-New Sor. the properties of synthesized AuNPs-New Sor were identified in a mouse model of tumori...
Source: Experimental Cell Research - June 5, 2021 Category: Cytology Authors: Wei Huang Yitao Xing Lile Zhu Jinsheng Zhuo Min Cai Source Type: research

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model
Conclusions: Our results indicate that the syncytiotrophoblast is the key player in regulating nanoparticle transport across the human placenta. The main mechanism underlying this translocation is not based on passive diffusion, but is likely to involve an active, energy-dependent transport pathway. These findings will be important for reproductive toxicology as well as for pharmaceutical engineering of new drug carriers. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. ...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Albumin Coating Prevents Cardiac Effect of the Magnetic Nanoparticles
We have showed that surface layer can determine cardiac effects of the magnetic nanoparticles (MNPs). Considering the high binding capacity of albumin and low side-effects, the aim of this study was to evaluate the influence of albumin coating on the cardiovascular effects of two manganese ferrite-based MNPs: citrate-coated and bare MNPs. Isolated rat hearts were perfused with citrate-coated magnetic nanoparticles (CiMNPs), citrate albumin-coated magnetic nanoparticles (CiAlbMNPs), bare magnetic nanoparticles (BaMNPs), and albumin-coated magnetic nanoparticles (AlbMNPs). CiMNPs induce a transient decrease in the left ventr...
Source: IEE Transactions on NanoBioscience - September 30, 2019 Category: Nanotechnology Source Type: research

Generation of Nano-pores in Silk Fibroin Films Using Silk Nanoparticles for Full-Thickness Wound Healing.
Abstract Silk fibroin films are used in tissue engineering due to their biocompatibility, optical clarity, and slow biodegradability. However, the relatively smooth surface and low permeability of these systems may limit some applications; thus, here, a method was developed to generate nano-pores in methanol or ethanol-treated silk fibroin films. The first step was to induce the formation of nanoparticles (50-300 nm diam.) in silk fibroin solutions by autoclaving. After drying in air, the films formed were treated to induce silk β-sheet structures, which condense the bulk silk phase and nanoparticles and phase se...
Source: Biomacromolecules - January 15, 2021 Category: Biochemistry Authors: Liu J, Huang R, Li G, Kaplan DL, Zheng Z, Wang X Tags: Biomacromolecules Source Type: research

Dual drug loaded chitosan nanoparticles-sugar-coated arsenal against pancreatic cancer.
Abstract Pancreatic cancer is an aggressive form of cancer with poor survival rates. The increased mortality due to pancreatic cancer arises due to many factors such as development of multidrug resistance, presence of cancer stem cells, development of a stromal barrier and a hypoxic environment due to hypo-perfusion. The present study aims to develop a nanocarrier for a combination of drugs that can address these multiple issues. Quercetin and 5-fluorouracil were loaded in chitosan nanoparticles, individually as well as in combination. The nanoparticles were characterized for morphology, size, zeta potential, perc...
Source: Colloids and Surfaces - August 28, 2015 Category: Biotechnology Authors: David KI, Jaidev LR, Sethuraman S, Krishnan UM Tags: Colloids Surf B Biointerfaces Source Type: research

Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a carrier material
This study aimed to construct lipid nanoparticles using broccoli-derived lipids for oral delivery of tripterine (Tri), a natural anticancer candidate, and to enhance its oral bioavailability. Tri-loaded broccoli lipid nanoparticles (Tri-BLNs) were prepared by a solvent-diffusion method. The resulting Tri-BLNs were 75±10nm in particle size with entrapment efficiency over 98%. In vitro release study indicated that Tri was almost not released from Tri-BLNs (<2%), whereas the lipolytic experiment showed that Tri-BLNs possessed a relatively strong anti-enzymatic degradation ability to Tri-CLNs (Tri-loaded common lipid n...
Source: International Journal of Pharmaceutics - October 21, 2015 Category: Drugs & Pharmacology Source Type: research

Radiolabeled long circulating nanoparticles for re-assessing the enhanced permeability and retention effect in peripheral arterial disease
Conclusions Thus, we quantitatively confirmed that 64Cu-RGO-IONP-PEG passively accumulated in ischemic tissue via the EPR effect, which is reduced as the perfusion normalizes. As 64Cu-RGO-IONP-PEG displayed substantial accumulation in the ischemic tissue, this nanoparticle platform may function as a future theranostic agent, providing both imaging and therapeutic applications.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: England, C., Im, H.-J., Chen, F., Hernandez, R., Cho, S., Nickles, R., Lee, D. S., Cai, W. Tags: Cardiovascular YIA Symposium Source Type: research

H2O2-responsive antioxidant polymeric nanoparticles as therapeutic agents for peripheral arterial disease
In this study, we investigated the therapeutic efficacy of PVAX nanoparticles for PAD using a cell culture model and a mouse model of hindlimb ischemia. PVAX nanoparticles significantly enhanced the expression of angiogenic inducers such as vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule (PECAM)-1 in human umbilical vein endothelial cells (HUVEC). PVAX nanoparticles promoted revascularization and restoration of blood perfusion into ischemic tissues by upregulating angiogenic VEGF and PECAM-1. This work demonstrates that H2O2-responsive PVAX nanoparticles facilitate therapeutic angi...
Source: International Journal of Pharmaceutics - August 17, 2016 Category: Drugs & Pharmacology Source Type: research