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Total 13525 results found since Jan 2013.
PLGA+Fe ₃O₄+PFP Nanoparticles Drug-Delivery Demonstrates Potential Anti-Tumor Effects on Tumor Cells
CONCLUSIONS PLGA+Fe₃O₄+PFP nanoparticles were safe, with higher invasive ability and binding efficiency of targeting CDDP with tumor cells. Therefore, PLGA+Fe₃O₄+PFP nanoparticles demonstrated potential anti-tumor effects after transplantation.PMID:35145054 | DOI:10.12659/AOT.933246
Source: Annals of Transplantation - February 11, 2022 Category: Transplant Surgery Authors: Dayan Yang Qiqing Chen Min Zhang Lin Xie Yan Chen Tingting Zhong Fang Tian Guiying Feng Xiangxiang Jing Ling Lin Source Type: research
Green synthesis of gold nanoparticles using a Cordyceps militaris extract and their antiproliferative effect in liver cancer cells (HepG2).
Authors: Ji Y, Cao Y, Song Y
Abstract
Hepatocellular carcinoma is the most common liver cancer among different types of cancers. Cordyceps Militaris mushroom species traditionally used as an alternative medicine in china for centuries. Gold nanoparticles plays vital role in the development of the anticancer drugs. In our research, we investigated the gold nanoparticles with C. Militaris on the hepatocellular carcinoma HepG2 cells. The synthesized gold nanoparticles stability and integrity was studied at different time intervals. The gold nanoparticles potentially halt the growth of the HepG2 cells at the IC50 conce...
Source: Artificial Cells, Nanomedicine and Biotechnology - July 17, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Clot-building nanoparticles raise survival rate following blast trauma Read more: Clot-building nanoparticles raise survival rate following blast trauma
A type of artificial platelet being developed to help natural blood platelets form clots faster offers promise for saving the lives of soldiers, as well as victims of car crashes and other severe trauma.In preclinical tests led by a Case Western Reserve University researcher, the artificial platelets, called "hemostatic nanoparticles," when injected after blast trauma dramatically increased survival rates and showed no signs of interfering with healing or causing other complications weeks afterward."The nanoparticles have a huge impact on survival—not just in the short term, but in the long term," said Erin Lavik, an ass...
Source: Medical Hemostat - June 30, 2014 Category: Technology Consultants Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs
Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature.
In conclusion, PLGA nanoparticle delivery to cultured vascular endothelial cells and mouse lungs in vivo is higher following bleomycin treatment, with the delivery tending to be higher for YSA functionalized nanoparticles.
PMID: 30450979 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - November 21, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Integrating Artificial Intelligence with Quality by Design in the Formulation of Lecithin/Chitosan Nanoparticles of a Poorly Water-Soluble Drug
AAPS PharmSciTech. 2023 Aug 8;24(6):169. doi: 10.1208/s12249-023-02609-5.ABSTRACTThe aim of the current study is to explore the potential of artificial intelligence (AI) when integrated with Quality by Design (QbD) approach in the formulation of a poorly water-soluble drug, for its potential use in carcinoma. Silymarin is used as a model drug for its potential effectiveness in liver cancer. A detailed QbD approach was applied. The effect of the critical process parameters was studied on each of the particle size, size distribution, and entrapment efficiency. Response surface designs were applied in the screening and optimi...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Marwa H S Dawoud Islam S Mannaa Amira Abdel-Daim Nabila M Sweed Source Type: research
Carnosic acid nanoparticles suppress liver ischemia/reperfusion injury by inhibition of ROS, Caspases and NF-κB signaling pathway in mice
In conclusion, our study suggested that carnosic acid nanoparticles protected against liver ischemia/reperfusion injury via its role of anti-oxidative, anti-apoptotic and anti-inflammatory bioactivity.
Source: Biomedicine and Pharmacotherapy - May 13, 2016 Category: Drugs & Pharmacology Source Type: research
Solid Lipid Nanoparticles and Chitosan-coated Solid Lipid Nanoparticles as Promising Tool for Silybin Delivery: Formulation, Characterization, and In Vitro Evaluation.
CONCLUSIONS: Together with the excellent stability, strong mucoadhesive property, and slow release, chitosan coated SLNs demonstrated promising potential to enhance absorption of hydrophobic Sb after oral administration.
PMID: 30306869 [PubMed - as supplied by publisher]
Source: Current Drug Delivery - October 8, 2018 Category: Drugs & Pharmacology Authors: Piazzini V, Cinci L, D'Ambrosio M, Luceri C, Bilia AR, Bergonzi MC Tags: Curr Drug Deliv Source Type: research
Hypothesizing the Green Synthesis of Tamoxifen Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
The objective of this hypothesis is to prepare tamoxifen-loaded PEGylated NiO nanoparticles using green chemistry, tumbling the toxic effects of the conventional method of synthesis for targeted delivery to breast cancer cells. Significance of the research work: The significance of the work is to hypothesize a green method for the synthesis of NiO nanoparticles that are eco-friendly, cost-effective, decrease multidrug resistance, and can be used for targeted therapy. Garlic extract contains an organosulfur compound (Allicin) which has drug-metabolizing, anti-oxidant, and tumour growth inhibition effects. In breast cancer, ...
Source: Current Molecular Medicine - May 26, 2023 Category: Molecular Biology Authors: Neha Tyagi Tanya Ralli Asgar Ali Kanchan Kohli Source Type: research
