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Total 40417 results found since Jan 2013.

PLGA+Fe ₃O₄+PFP Nanoparticles Drug-Delivery Demonstrates Potential Anti-Tumor Effects on Tumor Cells
CONCLUSIONS PLGA+Fe₃O₄+PFP nanoparticles were safe, with higher invasive ability and binding efficiency of targeting CDDP with tumor cells. Therefore, PLGA+Fe₃O₄+PFP nanoparticles demonstrated potential anti-tumor effects after transplantation.PMID:35145054 | DOI:10.12659/AOT.933246
Source: Annals of Transplantation - February 11, 2022 Category: Transplant Surgery Authors: Dayan Yang Qiqing Chen Min Zhang Lin Xie Yan Chen Tingting Zhong Fang Tian Guiying Feng Xiangxiang Jing Ling Lin Source Type: research

Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism
This study opens a promising way for targeted drug treatment of renal fibrosis.PMID:34529980 | DOI:10.1016/j.ejphar.2021.174501
Source: European Journal of Pharmacology - September 16, 2021 Category: Drugs & Pharmacology Authors: Qixia Liu Xiaohui Chen Min Kan Jing Yang Qian Gong Rui Jin Yulong Dai Juan Jin Hongmei Zang Source Type: research

H < sub > 2 < /sub > O < sub > 2 < /sub > -Activatable Antioxidant Polymeric Prodrug Nanoparticles for the Prevention of Renal Ischemia/Reperfusion Injury
In this study, we developed fucoidan-coated polymeric prodrug (Fu-PVU73) nanoparticles as renal IR-targeting nanotherapeutics that can rapidly eliminate H2O2 and exert anti-inflammatory and antiapoptotic effects. Fu-PVU73 nanoparticles were composed of H2O2-activatable antioxidant and anti-inflammatory polymeric prodrug (PVU73) that incorporated H2O2-responsive peroxalate linkages, ursodeoxycholic acid (UDCA), and vanillyl alcohol (VA) in its backbone. Fu-PVU73 nanoparticles rapidly scavenged H2O2 and released UDCA and VA during H2O2-triggered degradation. In the study of renal IR injury mouse models, Fu-PVU73 nanoparticle...
Source: Biomacromolecules - August 5, 2022 Category: Biochemistry Authors: Hyeonbin Shin Seungwon Jeong Yeongjong Lee Chanhee Jeon Gayoung Kwon Sooyeon Kim Dongwon Lee Source Type: research

Clot-building nanoparticles raise survival rate following blast trauma Read more: Clot-building nanoparticles raise survival rate following blast trauma
A type of artificial platelet being developed to help natural blood platelets form clots faster offers promise for saving the lives of soldiers, as well as victims of car crashes and other severe trauma.In preclinical tests led by a Case Western Reserve University researcher, the artificial platelets, called "hemostatic nanoparticles," when injected after blast trauma dramatically increased survival rates and showed no signs of interfering with healing or causing other complications weeks afterward."The nanoparticles have a huge impact on survival—not just in the short term, but in the long term," said Erin Lavik, an ass...
Source: Medical Hemostat - June 30, 2014 Category: Technology Consultants Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature.
In conclusion, PLGA nanoparticle delivery to cultured vascular endothelial cells and mouse lungs in vivo is higher following bleomycin treatment, with the delivery tending to be higher for YSA functionalized nanoparticles. PMID: 30450979 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - November 21, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Green synthesis of silver nanoparticles from Alpinia officinarum mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats.
Authors: Zhang Z, Xin G, Zhou G, Li Q, Veeraraghavan VP, Krishna Mohan S, Wang D, Liu F Abstract The rhizome of A. officinarum possesses immense pharmaceutical properties like antioxidant, anti-inflammatory, antiapoptotic, anticancer activities. The foremost downside of herbal-based drugs is their poor bioavailability, to trounce this we synthesized a herbal based silver nanodrug with Alpinia officinarum rhizome extract and assessed its effect against the cisplatin-induced nephrotoxicity in in vivo model. The A. officinarum biosynthesized silver nanoparticles (AG-AO) were characterized using UV-Spec, FTIR, XRD, TEM...
Source: Artificial Cells, Nanomedicine and Biotechnology - July 31, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green.
CONCLUSIONS: Taken together, these data indicate that poly(lactic-co-glycolic acid) nanoparticles may be used to label transplanted islets and may be imaged with in vivo MR and optical imaging systems. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. PMID: 23640738 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - May 2, 2013 Category: Radiology Authors: Hwang JH, Noh YW, Choi JH, Noh JR, Kim YH, Gang GT, Kim KS, Park HS, Lim YT, Moon H, Hong KS, Lee HG, Chung BH, Lee CH Tags: Magn Reson Med Source Type: research

In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green
ConclusionsTaken together, these data indicate that poly(lactic‐co‐glycolic acid) nanoparticles may be used to label transplanted islets and may be imaged with in vivo MR and optical imaging systems. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.
Source: Magnetic Resonance in Medicine - May 2, 2013 Category: Radiology Authors: Jung Hwan Hwang, Young‐Woock Noh, Jung‐Hyun Choi, Jung‐Ran Noh, Yong‐Hoon Kim, Gil‐Tae Gang, Kyoung‐Shim Kim, Hye Sun Park, Yong Taik Lim, Hyeyoung Moon, Kwan Soo Hong, Hee Gu Lee, Bong Hyun Chung, Chul‐Ho Lee Tags: Full Paper Source Type: research

Biological characteristics of adipose tissue-derived stem cells labeled with amine-surface-modified superparamagnetic iron oxide nanoparticles.
Abstract Cell labeling and tracking are becoming increasingly important areas within the field of stem cell transplantation. The ability to track the migration and distribution of implanted cells is critical to understanding the beneficial effects and mechanisms of stem cell therapy. The present study investigated the effects of amine-surface-modified superparamagnetic iron oxide (SPIO) nanoparticles on the biological properties of human adipose tissue-derived stem cells (hADSCs). Monodisperse hydrophobic magnetite (Fe3 O4 ) nanoparticles were prepared using silicon and surface-modified with amine coating. Cell vi...
Source: Cell Biology International - March 10, 2015 Category: Cytology Authors: Nan W, Jingyuan Z, Xin G, Yue D, Yang L, Xiang Z, Ren'an W, Yue D, Liang Z, Wei Z, Chao H, Lin S, Bo S, Yan L, Jing L Tags: Cell Biol Int Source Type: research