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Untargeted analysis of pure snail slime and snail slime ‐induced Au nanoparticles (AuNPs) metabolome with MALDI FT‐ICR MS
AbstractChronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. TheHelix Aspersa snail slime ‐based products are increasingly being used for skin injury, thanks to their ability to make tissue repair processes faster. To date, a comprehensive overview of pure snail slime metabolome is not available. Besides, Au nanoparti...
Source: Journal of Mass Spectrometry - March 15, 2021 Category: Chemistry Authors: Alberto Onzo,
Raffaella Pascale,
Maria Assunta Acquavia,
Pinalysa Cosma,
Jennifer Gubitosa,
Carmine Gaeta,
Patrizia Iannece,
Yuri Tsybin,
Vito Rizzi,
Antonio Guerrieri,
Rosanna Ciriello,
Giuliana Bianco Tags: RESEARCH ARTICLE Source Type: research
NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair
In this study, we investigated whether human umbilical cord mesenchymal stem cell (hUCMSC) fibrin patches loaded with nerve growth factor (NGF) poly(lactic-co-glycolic acid) (PLGA) nanoparticles could enhance the therapeutic potency of hUCMSCs for myocardial infarction (MI). In vitro, NGF significantly improved the proliferation of hUCMSCs and mitigated cytotoxicity and apoptosis under hypoxic injury. NGF also promoted the paracrine effects of hUCMSCs on angiogenesis and cardiomyocyte protection. The tyrosine kinase A (TrkA) and phosphoinositide 3-kinase (PI3K)-serine/threonine protein kinase (Akt) signaling pathways in hU...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Wei Luo Yanshan Gong Fan Qiu Yi Yuan Wenwen Jia Zhongmin Liu Ling Gao Source Type: research
Untargeted analysis of pure snail slime and snail slime ‐induced Au nanoparticles metabolome with MALDI FT‐ICR MS
AbstractChronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. TheHelix aspersa snail slime ‐based products are increasingly being used for skin injury, thanks to their ability to make tissue repair processes faster. To date, a comprehensive overview of pure snail slime metabolome is not available. Besides, Au nanoparti...
Source: Journal of Mass Spectrometry - April 5, 2021 Category: Chemistry Authors: Alberto Onzo,
Raffaella Pascale,
Maria Assunta Acquavia,
Pinalysa Cosma,
Jennifer Gubitosa,
Carmine Gaeta,
Patrizia Iannece,
Yuri Tsybin,
Vito Rizzi,
Antonio Guerrieri,
Rosanna Ciriello,
Giuliana Bianco Tags: RESEARCH ARTICLE Source Type: research
Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes
In conclusion, CH-CS nanoparticles can be considered as a candidate for gene therapy purposes in cartilage diseases.PMID:36049252 | DOI:10.1016/j.colsurfb.2022.112786
Source: Colloids and Surfaces - September 1, 2022 Category: Biotechnology Authors: Naghmeh Akbari Moghadam Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad Source Type: research
N-Hydroxysuccinamide functionalized iron oxide nanoparticles conjugated with 5-flurouracil for hyperthermic therapy of malignant liver cancer cells by DNA repair disruption
In this study, super paramagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) and anti-cancer drug, 5-fluorouracil, functionalized with N-Hydroxysuccinimide organic molecules. A specific absorption rate at 351 nm can be achieved using UV analysis. The magnetic Fe3O4 nanoparticles had a cubic crystalline structure. FE-SEM(field emission scanning Electron microscopy) with EDAX(energy dispersive X-ray analysis) analysis shows that the size of the SPION was about 30-100 nm range and the percentage of chemical compositions was higher in the order of Fe, O, C. for particle size analysis, the SPION were positively charged derived a...
Source: International Journal of Biological Macromolecules - August 2, 2023 Category: Biochemistry Authors: Subha Veeramani Lavanya Chandrababu Ilangovan Rajangam N Rajmuhon Singh Latifah Al-Humaid Nora Dahmash Al-Dahmash Ramachandran Balaji Narendhar Chandrasekar Michael Taeyoung Hwang Source Type: research
