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Total 22610 results found since Jan 2013.

Induction of Angiogenesis by Controlled Delivery of Vascular Endothelial Growth Factor Using Nanoparticles
ConclusionsDex‐GMA and gelatin‐based nanoparticles could provide sustained release of VEGF and may serve as a new way for angiogenesis.
Source: Cardiovascular Therapeutics - April 17, 2013 Category: Cardiology Authors: Jiaqi Xie, Haibin Wang, Yunya Wang, Fangping Ren, Wei Yi, Kun Zhao, Zilin Li, Qiang Zhao, Zhenhua Liu, Hong Wu, Chunhu Gu, Dinghua Yi Tags: Original Research Article Source Type: research

Gold nanoparticles as targeted delivery systems and theranostic agents in cancer therapy.
Abstract Cancer is still a leading cause of death worldwide, while most chemotherapies induce non-selective toxicity and severe systemic side effects. To address these problems, targeted nanoscience is an emerging field that promises to benefit cancer patients. Gold nanoparticles are nowadays in the spotlight due to their many well-established advantages. Gold nanoparticles are easily synthesizable in various shapes and sizes by a continuously developing set of means, including chemical, physical or eco-friendly biological methods. This review presents gold nanoparticles as versatile therapeutic agents playing man...
Source: Current Medicinal Chemistry - May 5, 2019 Category: Chemistry Authors: Mioc A, Mioc M, Ghiulai R, Voicu M, Babuta R, Trandafirescu C, Dehelean C, Coricovac D, Soica CM Tags: Curr Med Chem Source Type: research

Green formulation of curcumin loaded lipid-based nanoparticles as a novel carrier for inhibition of post-angioplasty restenosis
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Sarah Akhlaghi, Shahram Rabbani, Sonia Alavi, Azadeh Alinaghi, Fatemeh Radfar, Simin Dadashzadeh, Azadeh HaeriAbstractRestenosis is one of the major complications affecting outcomes of percutaneous coronary interventions. The aims of this study were to formulate curcumin (CUR) nanoparticles by using only lipidic ingredients in the absence of any organic solvent and to determine key formulation parameters using 2-level factorial design. CUR nanoparticles were prepared using triglyceride and egg phosphatidylcholine (EPC) by high...
Source: Materials Science and Engineering: C - August 7, 2019 Category: Materials Science Source Type: research

Ocular delivery of sunitinib-loaded nanoparticles doped in tragacanthic acid hydrogel in treatment of diabetic retinopathy in rats
Conclusions: Sunitinib nanoparticles doped in TA hydrogel may be an appropriate substitution of bevacizumab in the treatment of DR.PMID:35723593 | DOI:10.1080/03639045.2022.2092745
Source: Drug Development and Industrial Pharmacy - June 20, 2022 Category: Drugs & Pharmacology Authors: Sana Pirmardvand Chegini Jaleh Varshosaz Alireza Dehghani Mohsen Minaiyan Hamid Mirmohammad Sadeghi Source Type: research

Molecules, Vol. 24, Pages 1401: Biomimetic Mineralization of Magnetic Iron Oxide Nanoparticles Mediated by Bi-Functional Copolypeptides
Yuhao Wu Magnetite (Fe3O4) nanoparticles are widely used in multiple biomedical applications due to their magnetic properties depending on the size, shape and organization of the crystals. However, the crystal growth and morphology of Fe3O4 nanoparticles remain difficult to control without using organic solvent or a high temperature. Inspired by the natural biomineralization process, a 14-mer bi-functional copolypeptide, leveraging the affinity of binding Fe3O4 together with targeting ovarian cancer cell A2780, was used as a template in the biomimetic mineralization of magnetite. Alongside this, a ginger extract was...
Source: Molecules - April 9, 2019 Category: Chemistry Authors: Liu Liu Ximing Pu Guangfu Yin Xianchun Chen Jie Yin Yuhao Wu Tags: Article Source Type: research

X-ray Visible and Uniform Alginate Microspheres Loaded with in situ Synthesized BaSO4 Nanoparticles for in vivo Transcatheter Arterial Embolization.
Abstract The lack of non-invasive tracking and mapping the fate of embolic agents has restricted the development and further applications of the transcatheter arterial embolization (TAE) therapy. In this work, inherent radiopaque embolic material, barium alginate (ALG) microspheres loaded with in situ synthesized BaSO4 (denoted as BaSO4/ALG microspheres), have been synthesized by one-step droplet microfluidic technique. One of the advantages of our microfluidic approach is that radiopaque BaSO4 is in the form of nanoparticles and well dispersed inside ALG microspheres, thereby greatly enhancing the imaging quality...
Source: Biomacromolecules - March 2, 2015 Category: Biochemistry Authors: Wang Q, Qian K, Liu S, Yang Y, Liang B, Zheng C, Yang XL, Xu HB, Shen AQ Tags: Biomacromolecules Source Type: research

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles
Conclusions: This multimodal MPI approach revealed that active MPO-targeted nanoparticles might serve as a method for detecting vulnerable atherosclerotic plaques and monitoring MPO activity.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Wei Tong, Hui Hui, Wenting Shang, Yingqian Zhang, Feng Tian, Qiang Ma, Xin Yang, Jie Tian, Yundai Chen Tags: Research Paper Source Type: research

Development of X-ray contrast agents using single nanometer-sized gold nanoparticles and lactoferrin complex and their application in vascular imaging
Colloids Surf B Biointerfaces. 2021 Apr 1;203:111732. doi: 10.1016/j.colsurfb.2021.111732. Online ahead of print.ABSTRACTThe technology to accurately image the morphology of tumor vessels with X-ray contrast agents is important to clarify mechanisms underlying tumor progression and evaluate the efficacy of chemotherapy. However, in clinical practice, iodine-based contrast agents present problems such as short blood retention owing to a high clearance ability and insufficient X-ray absorption capacity when compared with other high atomic number elements. To resolve these issues, gold nanoparticles (AuNPs), with a high atomi...
Source: Colloids and Surfaces - April 11, 2021 Category: Biotechnology Authors: Tomoya Inose Narufumi Kitamura Mayumi Takano-Kasuya Masayuki Tokunaga Norikazu Une Chihiro Kato Mayu Tayama Yukina Kobayashi Noriko Yamauchi Daisuke Nagao Takuji Aimiya Naoko Furusawa Yasushi Nakano Yoshio Kobayashi Kohsuke Gonda Source Type: research

Investigation of the Characteristics of New, Uniform, Extremely Small Iron-Based Nanoparticles as T1 Contrast Agents for MRI
CONCLUSION: In the phantom experiments, the ESIONs with 3-4-nm iron oxide cores showed a good T1 shortening effect at 1.5T and 3T. In the animal experiments, the ESIONs with 3-nm iron cores showed comparable enhancement on the first-pass images and superior enhancement effect on the delayed images compared to the commercially available GBCA at 3T.PMID:34402245 | DOI:10.3348/kjr.2020.1455
Source: Korean J Radiol - August 17, 2021 Category: Radiology Authors: Young Ho So Whal Lee Eun Ah Park Pan Ki Kim Source Type: research