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Nanoparticles On My Mind
By KIM BELLARD Nanoparticles are everywhere!  By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare.   But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger. Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants.  They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs

Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers
ai-jun Yu
Source: Acta Pharmacologica Sinica - January 3, 2017 Category: Drugs & Pharmacology Authors: Jian-ping Liu Ting-ting Wang Dang-ge Wang An-jie Dong Ya-ping Li Hai-jun Yu Tags: solid tumors chemotherapy drug resistance pathophysiological barriers tumor microenvironment nanomedicine smart nanoparticles Source Type: research

Bovine serum albumin nanoparticles containing amphotericin B were effective in treating murine cutaneous leishmaniasis and reduced the drug toxicity.
This study investigated the antileishmanial activity of bovine serum albumin (BSA) nanoparticles containing amphotericin B (AmB) against Leishmania amazonensis. The antiproliferative activity against promastigotes and amastigotes was assessed and the cytotoxicity was determined and compared to commercial AmB-deoxycholate (AmB-D). In vivo antileishmania activity was evaluated in murine cutaneous leishmaniasis model. BSA nanoparticles showed spherical shape, mean size about 180 nm, zeta potential of ≈ -45 mV and AmB encapsulation efficiency >95%. AmB-D was effective in promastigote and amastigote forms, while Am...
Source: Experimental Parasitology - July 16, 2018 Category: Parasitology Authors: Casa DM, Scariot DB, Khalil NM, Nakamura CV, Mainardes RM Tags: Exp Parasitol Source Type: research

Gold Nanoparticles: Promising Agent To Improve The Diagnosis And Therapy Of Cancer.
CONCLUSION: Gold nanoparticles have greatly improved the traditional treatment due to their unique properties. However, their size-dependent toxicity, distribution and clearance need further studies to make them a clinical reality. PMID: 28952430 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - September 25, 2017 Category: Drugs & Pharmacology Authors: Ning L, Zhu B, Gao T Tags: Curr Drug Metab Source Type: research

Antiproliferative activity of Camellia sinensis mediated silver nanoparticles on three different human cancer cell lines
Conclusion: The superior activity of the silver nanoparticles may be due to its spherical shape and smaller particle size 10–30 nm as confirmed from NTA and TEM analysis. The data obtained in the study reveal the potent therapeutic value of biogenic silver nanoparticles.
Source: Journal of Cancer Research and Therapeutics - November 28, 2018 Category: Cancer & Oncology Authors: Anu Yadav Vijay D Mendhulkar Source Type: research

64Copper labelled nanoparticles for PET Imaging: a review of the recent literature.
CONCLUSIONS: The results showed that nanoparticles can be considered a promising radiopharmaceutical for PET imaging of different type of cancer. PMID: 33073558 [PubMed - as supplied by publisher]
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - October 21, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Overview of inorganic nanoparticles: An expanding horizon in tumor therapeutics
CONCLUSION: This review paper concludes that inorganic nanoparticles may be better alternatives to conventional approaches for the treatment of cancer. However, their presence in global pharmaceutical markets will be governed by the development of novel scale-up techniques and clinical evaluation.PMID:36200151 | DOI:10.2174/1574892817666221005094423
Source: Recent Patents on Anti-Cancer Drug Discovery - October 6, 2022 Category: Cancer & Oncology Authors: Lalit Kumar Shivani Verma Puneet Utreja Dinesh Kumar Source Type: research

Molecules, Vol. 28, Pages 3228: Therapeutic Potential of Albumin Nanoparticles Encapsulated Visnagin in MDA-MB-468 Triple-Negative Breast Cancer Cells
iah Pooi Ling Mok Breast cancer is among the most recurrent malignancies, and its prevalence is rising. With only a few treatment options available, there is an immediate need to search for better alternatives. In this regard, nanotechnology has been applied to develop potential chemotherapeutic techniques, particularly for cancer therapy. Specifically, albumin-based nanoparticles are a developing platform for the administration of diverse chemotherapy drugs owing to their biocompatibility and non-toxicity. Visnagin, a naturally derived furanochromone, treats cancers, epilepsy, angina, coughs, and inflammatory illnes...
Source: Molecules - April 4, 2023 Category: Chemistry Authors: Abdullah Alsrhani Abozer Y. Elderdery Badr Alzahrani Nasser A. N. Alzerwi Maryam Musleh Althobiti Musaed Rayzah Bandar Idrees Ahmed M. E. Elkhalifa Suresh K. Subbiah Pooi Ling Mok Tags: Article Source Type: research

A nanotechnology based strategy to increase the efficiency of cancer diagnosis and therapy: Folate conjugated gold nanoparticles.
CONCLUSION: This review identifies the important roles of F-AuNPs in current cancer researches which are undertaken worldwide. The findings of this review confirm that F-AuNP is a new theranostic agent which has great potentials for simultaneous cancer therapy and diagnosis. PMID: 28799495 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - August 10, 2017 Category: Chemistry Authors: Beik J, Khademi S, Attaran N, Sarkar S, Shakeri-Zadeh A, Ghaznavi H, Ghadiri H Tags: Curr Med Chem Source Type: research

Immunomodulatory roles of selenium nanoparticles: Novel arts for potential immunotherapy strategy development
Front Immunol. 2022 Jul 26;13:956181. doi: 10.3389/fimmu.2022.956181. eCollection 2022.ABSTRACTCurrent chemotherapy strategies used in clinic appear with lots of disadvantages due to the low targeting effects of drugs and strong side effects, which significantly restricts the drug potency, causes multiple dysfunctions in the body, and even drives the emergence of diseases. Immunotherapy has been proved to boost the body's innate and adaptive defenses for more effective disease control and treatment. As a trace element, selenium plays vital roles in human health by regulating the antioxidant defense, enzyme activity, and im...
Source: Cancer Control - August 12, 2022 Category: Cancer & Oncology Authors: Gengshi Chen Fen Yang Shuhao Fan Hua Jin Kangsheng Liao Xuemeng Li Gan-Bin Liu Jing Liang Junai Zhang Jun-Fa Xu Jiang Pi Source Type: research

Electrochemical molecularly bioimprinted siloxane biosensor on the basis of core/shell silver nanoparticles/EGFR exon 21 L858R point mutant gene/siloxane film for ultra-sensing of Gemcitabine as a lung cancer chemotherapy medication
Publication date: Available online 9 September 2019Source: Biosensors and BioelectronicsAuthor(s): Yalda Shoja, Ahmad Kermanpur, Fathallah Karimzadeh, Javad Ghodsi, Amir Abbas Rafati, Siavash AdhamiAbstractIn search for improvements in bioanalysis electrochemical sensors, for better assessment of anti-cancer drugs, it is necessary for their detection limits to be minimized and the sensitivity and selectivity to be surpassed simultaneously; whereas, resolving any probable interfering with other medical treatments are considered. In this work, a novel approach was adopted for detection and assessment of Gemcitabine (GEM) as ...
Source: Biosensors and Bioelectronics - September 10, 2019 Category: Biotechnology Source Type: research