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Nanoparticles to Target Atherosclerotic Plaques
This popular science article takes a look at efforts to develop nanoparticles capable of reducing the size of plaques in blood vessels produced by the processes of atherosclerosis. These plaques narrow and deform blood vessels, ultimately breaking apart to cause blockages and ruptures of blood vessels that are often fatal. Atherosclerosis is caused at root by damaged lipids that enter the circulation and lodge in blood vessel tissue. This is followed by an unfortunate set of self-reinforcing signals sent by cells in the blood vessel wall and then by immune cells that turn up to try to deal with the problem. When immune cel...
Source: Fight Aging! - May 31, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis
Biomed Pharmacother. 2021 Jul 13;141:111900. doi: 10.1016/j.biopha.2021.111900. Online ahead of print.ABSTRACTThe efficiency of cholesterol efflux from cells promoted by high-density lipoproteins (HDLs) depends on HDL concentration and functional properties. The term "dysfunctional HDL" describes HDLs with impaired protective properties. Cholesterol efflux capacity (CEC) of HDL is reduced in patients with atherosclerosis, but the exact mechanisms underlying this impairment are not well characterized. Enriching HDLs with phospholipids (PLs) improves CEC. Herein, we assessed the potential of PL nanoparticles in improving HDL...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Vasily A Kudinov Tatiana I Torkhovskaya Tamara S Zakharova Galina E Morozevich Rafael I Artyushev Marina Yu Zubareva Sergey S Markin Source Type: research
Enhancing the biopharmaceutical attributes of atorvastatin calcium using polymeric and lipid-polymer hybrid nanoparticles: An approach for atherosclerosis treatment
Biomed Pharmacother. 2023 Jan 21;159:114261. doi: 10.1016/j.biopha.2023.114261. Online ahead of print.ABSTRACTAtherosclerosis is associated with inflammation in the arteries, a significant cause of heart attacks and strokes. Although statin therapy can reduce the chances of atherosclerotic plaque formation, they need to be administered in high doses due to low systemic bioavailability and encountered with side effects. To overcome these challenges, we developed nanoparticles using biocompatible and biodegradable lipids and polymers for improving systemic drug absorption and therapeutic response. The polymeric nanoparticles...
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Miao Liu Tingchao Gao Lei Jiang Shunqi Li Bolun Shi Fangxu Li Source Type: research
Inhaled Atorvastatin Nanoparticles For Lung Cancer
CONCLUSION: This study found that atorvastatin micellar nanoparticles for inhalation could potentially be used for lung cancer treatment.PMID:35473526 | DOI:10.2174/1567201819666220426091500
Source: Current Drug Delivery - April 27, 2022 Category: Drugs & Pharmacology Authors: Alaa S Tulbah Source Type: research
Thermosensitive chitosan/poly(N-isopropyl acrylamide) nanoparticles embedded in aniline pentamer/silk fibroin/polyacrylamide as an electroactive injectable hydrogel for healing critical-sized calvarial bone defect in aging rat model
Int J Biol Macromol. 2022 May 28:S0141-8130(22)01166-7. doi: 10.1016/j.ijbiomac.2022.05.176. Online ahead of print.ABSTRACTThermosensitive nanoparticles with phase transition abilities upon temperature change have been considered suitable materials in biomedical fields, especially thermo-sensitive drug delivery systems. Moreover, electroactive injectable hydrogel supporting bone regeneration of the elderly will highly be desired in bone tissue engineering applications. Herein, thermosensitive nanoparticles were fabricated using chitosan/poly(N-isopropyl acrylamide) for simvastatin acid delivery. The nanoparticles were inco...
Source: International Journal of Biological Macromolecules - May 31, 2022 Category: Biochemistry Authors: Negin Khaneh Zarrin Fatemeh Mottaghitalab Rui L Reis Subhas C Kundu Mehdi Farokhi Source Type: research
Pitavastatin loaded nanoparticles: a suitable ophthalmic treatment for Acanthamoeba Keratitis inducing cell death and autophagy in Acanthamoeba polyphaga
Eur J Pharm Biopharm. 2022 Sep 23:S0939-6411(22)00215-6. doi: 10.1016/j.ejpb.2022.09.020. Online ahead of print.ABSTRACTStatins are effective sterol lowering agents with high amoebicidal activity. Nevertheless, due to their poor aqueous solubility, they remain underused especially in eye drop formulation. The aim of the present study is to develop Pitavastatin loaded nanoparticles suitable for ophthalmic administration and designed for the management of Acanthamoeba Keratitis. These nanocarriers are aimed to solve both the ophthalmic route-associated problems and the limited aqueous drug solubility issues of Pitavastatin. ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 26, 2022 Category: Drugs & Pharmacology Authors: Ines Sifaoui Patricia D íaz-Rodríguez Rub én L Rodríguez-Expósito Mar ía Reyes-Batlle Atteneri Lopez-Arencibia Lizbeth Salazar Villatoro Ismael Castelan-Ram írez Maritza Oma ña-Molina Alexis Oliva Jos é E Piñero Jacob Lorenzo-Morales Source Type: research
