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Therapy: Stem Cell Therapy

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Injectable calcium phosphate scaffold with iron oxide nanoparticles to enhance osteogenesis via dental pulp stem cells.
In conclusion, it is highly promising to incorporate γIONPs and αIONPs into CPC scaffold for bone tissue engineering, yielding substantially better stem cell attachment, spreading and osteogenic differentiation, and much greater bone mineral synthesis by the seeded cells. Therefore, novel CPC scaffolds containing γIONPs and αIONPs are promising for dental, craniofacial and orthopaedic applications to substantially enhance bone regeneration. PMID: 29355052 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 24, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Toxicity and health impact of nanoparticles. Basic biology and clinical perspective.
Authors: Olaru DG, Olaru A, Kassem GH, Popescu-Drigă MV, Pinoşanu LR, Dumitraşcu DI, Popescu EL, Hermann DM, Popa-Wagner A Abstract Stroke has limited restorative treatment options. In search of new therapeutic strategies for the ischemic brain, cell-based therapies offered new hope, which has been, in the meanwhile, converted into a more realistic approach recognizing difficulties related to unfavorable environments causing low survival rates of transplanted neuronal precursors. Stem cell therapies are based on the transplantation of neuronal precursor cells (NPCs), adult stem cells propagated in cell culture o...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

In Vivo Efficacy and Toxicity of Curcumin Nanoparticles in Breast Cancer Treatment: A Systematic Review
Breast cancer is one of the most prevalent types of malignant tumors in the world, resulting in a high incidence of death. The development of new molecules and technologies aiming to apply more effective and safer therapy strategies has been intensively explored to overcome this situation. The association of nanoparticles with known antitumor compounds (including plant-derived molecules such as curcumin) has been considered an effective approach to enhance tumor growth suppression and reduce adverse effects. Therefore, the objective of this systematic review was to summarize published data regarding evaluations about effic...
Source: Frontiers in Oncology - March 9, 2021 Category: Cancer & Oncology Source Type: research

Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria
As the threat of antimicrobial-resistant bacteria compromises the safety and efficacy of modern healthcare practices, the search for effective treatments is more urgent than ever. For centuries, silver (Ag) has been known to have antibacterial properties and, over the past two decades, Ag-based nanoparticles have gained traction as potential antimicrobials. The antibacterial efficacy of Ag varies with structure, size, and concentration. In the present study, we examined Ag nanoparticles (AgNPs) for their antimicrobial activity and safety. We compared different commercially-available AgNPs against gram-negative Escherichia ...
Source: Frontiers in Microbiology - January 31, 2023 Category: Microbiology Source Type: research

Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis
Conclusion: This study highlights the therapeutic role of stem cells in stroke and also emphasizes nanotechnology as an important tool for monitoring stem cell migration to the affected neurological locus.
Source: Stem Cell Research and Therapy - March 13, 2015 Category: Stem Cells Authors: Leopoldo NucciHelio SilvaViviana GiampaoliJavier MamaniMariana NucciLionel Gamarra Source Type: research

NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair
In this study, we investigated whether human umbilical cord mesenchymal stem cell (hUCMSC) fibrin patches loaded with nerve growth factor (NGF) poly(lactic-co-glycolic acid) (PLGA) nanoparticles could enhance the therapeutic potency of hUCMSCs for myocardial infarction (MI). In vitro, NGF significantly improved the proliferation of hUCMSCs and mitigated cytotoxicity and apoptosis under hypoxic injury. NGF also promoted the paracrine effects of hUCMSCs on angiogenesis and cardiomyocyte protection. The tyrosine kinase A (TrkA) and phosphoinositide 3-kinase (PI3K)-serine/threonine protein kinase (Akt) signaling pathways in hU...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Wei Luo Yanshan Gong Fan Qiu Yi Yuan Wenwen Jia Zhongmin Liu Ling Gao Source Type: research

Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles
This study would lead to the development of therapies targeting both cancer cells and CSCs simultaneously using nanoformulated drugs, which could bring changes in the current cancer treatment strategies.PMID:35738074 | DOI:10.1016/j.colsurfb.2022.112612
Source: Colloids and Surfaces - June 23, 2022 Category: Biotechnology Authors: Lizha Mary Lazer Yasodha Kesavan Ravi Gor Ilangovan Ramachandran Surajit Pathak Shoba Narayan Muralidharan Anbalagan Satish Ramalingam Source Type: research

Microfluidic synthesis of zoledronic acid loaded chitosan nanoparticles used for osteogenic differentiation of mesenchymal cells
Int J Biol Macromol. 2022 Dec 29:S0141-8130(22)03196-8. doi: 10.1016/j.ijbiomac.2022.12.275. Online ahead of print.ABSTRACTZoledronic acid (ZA) is known as a potent bisphosphonate in osteogenic differentiation, but at high doses, it possesses toxic effects and causes decreased proliferation and differentiation of osteoblasts. Therefore, encapsulation of ZA into nanoparticles and control of its release is expected to promote differentiation of stem cells into osteoblasts. The present work aimed to develop a simple method for synthesis of monodisperse ZA-loaded chitosan (CS) nanoparticles. In this regard, we proposed a micro...
Source: International Journal of Biological Macromolecules - January 1, 2023 Category: Biochemistry Authors: Maryam Khayati Hamidreza Kheiri Manjili Masoud Soleimani Simzar Hosseinzadeh Mohammad Akrami Ismaeil Haririan Seyed Hossein Ahmadi Tafti Source Type: research

Preconditioned human dental pulp stem cells with cerium and yttrium oxide nanoparticles effectively ameliorate diabetic hyperglycemia while combatting hypoxia
CONCLUSION: The achieved results highlight the promising role of the Cerium & Yttrium oxide nanoparticles in promoting the generation of IPCs that have the ability to combat hypoxia and govern diabetes mellitus.PMID:34656024 | DOI:10.1016/j.tice.2021.101661
Source: Tissue and Cell - October 16, 2021 Category: Cytology Authors: Hanaa H Ahmed Hadeer A Aglan Nadia S Mahmoud Riham M Aly Source Type: research