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Nanoparticles On My Mind
By KIM BELLARD Nanoparticles are everywhere!  By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare.   But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger. Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants.  They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
J Nanopart Res. 2023;25(3):43. doi: 10.1007/s11051-023-05690-w. Epub 2023 Feb 27.ABSTRACTRapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this ...
Source: Cell Research - March 6, 2023 Category: Cytology Authors: Reza Abbasi Ghazal Shineh Mohammadmahdi Mobaraki Sarah Doughty Lobat Tayebi Source Type: research

Exosomes as Immunotheranostic Nanoparticles.
CONCLUSION: Exosomes have numerous functions, and their double-edged features make the scope of their clinical applications, as both a diagnostic and therapeutic tool, immense. PMID: 24863261 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - May 23, 2014 Category: Drugs & Pharmacology Authors: Natasha G, Gundogan B, Tan A, Farhatnia Y, Wu W, Rajadas J, Seifalian AM Tags: Clin Ther Source Type: research

Folic acid-decorated PEGylated magnetite nanoparticles as efficient drug carriers to tumor cells overexpressing folic acid receptor
In conclusion, the FA-functionalized magnetic systems can ensure a better internalization of the nanoparticles and can be used to deliver various therapeutic agents, both in cancer treatment and also in the treatment of other inflammation-associated diseases such as rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, Crohn's disease or atherosclerosis.PMID:35952802 | DOI:10.1016/j.ijpharm.2022.122064
Source: Atherosclerosis - August 11, 2022 Category: Cardiology Authors: Codina Movileanu Maria Anghelache Mihaela Turtoi Geanina Voicu Ionela Andreea Neacsu Denisa Ficai Roxana Trusca Ovidiu Oprea Anton Ficai Ecaterina Andronescu Manuela Calin Source Type: research

Mannosylated polylactic-co-glycolic acid (MN-PLGA) nanoparticles induce potent anti-tumor immunity in murine model of breast cancer
Biomed Pharmacother. 2021 Aug 4;142:111962. doi: 10.1016/j.biopha.2021.111962. Online ahead of print.ABSTRACTNanoparticle-based cancer immunotherapy is considered a novel and promising therapeutic strategy aimed at stimulating host immune responses against tumors. To this end, in the present study, mannan-decorated polylactic-co-glycolic acid (PLGA) nanoparticles containing tumor cell lysate (TCL) and poly riboinosinic polycytidylic acid (poly I:C) were used as antigen delivery systems to immunize breast tumor-bearing Balb/c mice. PLGA nanoparticles were fabricated employing a double emulsion solvent evaporation method. Th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2021 Category: Drugs & Pharmacology Authors: Sanaz Sheikhzadeh Nowruz Delirezh Rahim Hobbenaghi Source Type: research

Surface-engineered nanoparticles in cancer immune response and immunotherapy: Current status and future prospects
Biomed Pharmacother. 2022 Nov 15;157:113998. doi: 10.1016/j.biopha.2022.113998. Online ahead of print.ABSTRACTCancer immunotherapy is a therapeutic strategy to inhibit tumor growth and metastasis by intervening in the immune response process. Strategies applied to cancer immunotherapy mainly include blocking immune checkpoints, adoptive transfer of engineered immune cells, cytokine therapy, cancer vaccines, and oncolytic virus infection. However, many factors, such as off-target side effects, immunosuppressive cell infiltration and/or upregulation of immune checkpoint expression, cancer cell heterogeneity, and lack of anti...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 18, 2022 Category: Drugs & Pharmacology Authors: Jun Chen Xiufeng Cong Source Type: research

Polymeric nanoparticles for DNA vaccine-based cancer immunotherapy: a review
Biotechnol Lett. 2023 Jun 19. doi: 10.1007/s10529-023-03383-x. Online ahead of print.ABSTRACTCancer is one of the leading causes of death and mortality in the world. There is an essential need to develop new drugs or therapeutic approaches to manage treatment-resistant cancers. Cancer immunotherapy is a type of cancer treatment that uses the power of the body's immune system to prevent, control, and eliminate cancer. One of the materials used as a vaccine in immunotherapy is DNA. The application of polymeric nanoparticles as carriers for DNA vaccines could be an effective therapeutic approach to activate immune responses a...
Source: Biotechnology Letters - June 19, 2023 Category: Biotechnology Authors: Mohsen Danaeifar Babak Negahdari Houra Mobaleghol Eslam Hamed Zare Momeneh Ghanaat Sekinehe Shokouhi Koushali Ziba Veisi Malekshahi Source Type: research

The biodistribution of self-assembling protein nanoparticles shows they are promising vaccine platforms
Conclusions: The data suggest that the nanoparticles are non-specifically taken up by the reticuloendothelial system. Low uptake in the pancreas and tumor indicate that there is little or no specific targeting. PEGylation or increasing the amount of bombesins per nanoparticle did not significantly improve targeting. In particular, the uptake in the spleen, which is a primary organ of the immune system, highlights the potential of the nanoparticles as vaccine carriers. Also, the decrease in liver and spleen radioactivity with time implies that the nanoparticles are broken down and cleared. This is an important finding, as i...
Source: Journal of Nanobiotechnology - November 12, 2013 Category: Nanotechnology Authors: Yongkun YangTobias NeefChristian MittelholzerElisa Garcia GarayoaPeter BläuensteinRoger SchibliUeli AebiPeter Burkhard Source Type: research

Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug.
CONCLUSION: The findings of this review identified that the biodegradable polymeric nanoparticles were used as delivery carrier for drug currently. It also indicates that the biodegradable polymeric nanoparticles play an important role in the drug delivery. PMID: 27230997 [PubMed - in process]
Source: Current Drug Delivery - May 29, 2016 Category: Drugs & Pharmacology Authors: Zhao K, Li D, Shi C, Ma X, Rong G, Kang H, Wang X, Sun B Tags: Curr Drug Deliv Source Type: research

Nanotechnology in Healthcare: Getting Smaller and Smarter
We are living at the dawn of the nanomedicine age. I believe that nanoparticles and nanodevices will soon operate as precise drug delivery systems, cancer treatment tools or tiny surgeons. Let me introduce you the brave, new world of nanotechnology in healthcare. Nanorobots having nanobreakfast with your red and white blood cells When I was a kid, one of my favorite TV series was a French animation, Il était un fois… la vie (1986). I found it fascinating how the creators imagined the human body as a construction where tiny cars floated through the human veins, grab-cranes worked on teeth and bacteria as tiny monsters tr...
Source: The Medical Futurist - November 3, 2016 Category: Information Technology Authors: nora Tags: Nanotechnology in Medicine cancer treatment drug delivery system future GC1 Healthcare Innovation nanodevices nanoparticles robotics wearables Source Type: blogs

Optimization of large-scale manufacturing of biopolymeric and lipid nanoparticles using microfluidic swirl mixers
In this study, we present a novel microfluidic design (swirl mixer) that helps accelerating the translation of many DDSs from laboratory to clinical application. The new swirl mixer provides high production rate, reproducibility, and precise control of particle size with low polydispersity index (PDI). To assess the performance of the swirl mixer, two different types of nanoformulations were used: silk nanoparticles (SNPs) and lipid nanoparticles (LNPs). The microfluidic device produced NPs efficiently with high productivity and allow for tuning the mean size and size distribution by changing multiple processing parameters...
Source: Cancer Control - April 26, 2022 Category: Cancer & Oncology Authors: Mhd Anas Tomeh Muhamad Hawari Mansor Roja Hadianamrei Weizhen Sun Xiubo Zhao Source Type: research

Glycolysis in human cancers: Emphasis circRNA/glycolysis axis and nanoparticles in glycolysis regulation in cancer therapy
Environ Res. 2023 Apr 27:116007. doi: 10.1016/j.envres.2023.116007. Online ahead of print.ABSTRACTThe metabolism of cancer has been an interesting hallmark and metabolic reprogramming, especially the change from oxidative phosphorylation in mitochondria to glucose metabolism known as glycolysis occurs in cancer. The molecular profile of glycolysis, related molecular pathways and enzymes involved in this mechanism such as hexokinase have been fully understood. The glycolysis inhibition can significantly decrease tumorigenesis. On the other hand, circRNAs are new emerging non-coding RNA (ncRNA) molecules with potential biolo...
Source: Environmental Research - April 29, 2023 Category: Environmental Health Authors: Ali G Alkhathami Ameer S Sahib Majed Saad Al Fayi Ali Abdulhussain Fadhil Mohammed Abed Jawad Sahar Ahmad Shafik Safwan Jassim Sultan Abbas F Almulla Min Shen Source Type: research

The Cooperation of IL-29 and PLGA Nanoparticles Improves the Protective Immunity of the gD-1 DNA Vaccine Against Herpes Simplex Virus Type 1 in Mice
In this study, the pIL-29 encapsulated in PLGA nanoparticles (nanoIL-29) and the pgD1 encapsulated in PLGA nanoparticles (nanoVac) were simultaneously applied to boost immunologic responses against HSV-1. We generated spherical nanoparticles with encapsulation efficiency of 75 ± 5% and sustained the release of plasmids from them. Then, Balb/c mice were subcutaneously immunized twice with nanoVac+nanoIL-29, Vac+IL-29, nanoVac, Vac, nanoIL-29, and/or IL-29 in addition to negative and positive control groups. Cellular immunity was evaluated via lymphocyte proliferation assay, cytotoxicity test, and IFN-γ, IL-4, and IL-2 mea...
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Parisa Amir Kalvanagh Hesam Karimi Hoorieh Soleimanjahi Massoumeh Ebtekar Parviz Kokhaei Zahra Matloubi Roghieh Rahimi Nazanin Atieh Kazemi-Sefat Hajar Rajaei Source Type: research

Poly- γ-glutamic acid nanoparticles as adjuvant and antigen carrier system for cancer vaccination
J Control Release. 2023 Aug 26:S0168-3659(23)00547-3. doi: 10.1016/j.jconrel.2023.08.049. Online ahead of print.ABSTRACTVaccination is an innovative strategy for cancer treatment by leveraging various components of the patients' immunity to boost an anti-tumor immune response. Rationally designed nanoparticles are well suited to maximize cancer vaccination by the inclusion of immune stimulatory adjuvants. Also, nanoparticles might control the pharmacokinetics and destination of the immune potentiating compounds. Poly-γ-glutamic acid (γ-PGA) based nanoparticles (NPs), which have a natural origin, can be easily taken up by...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Vahideh Mohammadzadeh Niloufar Rahiman Horacio Cabral Sabina Quader Mohammad Reza Zirak Mohammad Ehsan Taghavizadeh Yazdi Mahmoud Reza Jaafari Seyedeh Hoda Alavizadeh Source Type: research