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Nanoparticles On My Mind
By KIM BELLARD Nanoparticles are everywhere!  By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare.   But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger. Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants.  They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs

Nanoparticles: The new One True Cause of All Disease?
They're here, they're there, they're everywhere! If you believe certain quacks, nanoparticles are the new One True Cause of All Disease, and the evil food industry and big pharma are trying to poison you with them.
Source: Respectful Insolence - February 8, 2017 Category: Surgery Authors: Orac Tags: Complementary and alternative medicine Pseudoscience Quackery Skepticism/critical thinking antivaccine Antonietta Gatti nanoparticles Sayer Ji Stefano Montanari vaccines Source Type: blogs

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
J Nanopart Res. 2023;25(3):43. doi: 10.1007/s11051-023-05690-w. Epub 2023 Feb 27.ABSTRACTRapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this ...
Source: Cell Research - March 6, 2023 Category: Cytology Authors: Reza Abbasi Ghazal Shineh Mohammadmahdi Mobaraki Sarah Doughty Lobat Tayebi Source Type: research

Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics
Adv Colloid Interface Sci. 2023 Apr 12;315:102903. doi: 10.1016/j.cis.2023.102903. Online ahead of print.ABSTRACTThe respiratory tract is one of the most accessible ones to exogenous nanoparticles, yet drug delivery by their means to it is made extraordinarily challenging because of the plexus of aerodynamic, hemodynamic and biomolecular factors at cellular and extracellular levels that synergistically define the safety and efficacy of this process. Here, the use of inorganic nanoparticles (INPs) for inhalable diagnostics and therapies of the lung is viewed through the prism of the history of studies on the interaction of ...
Source: Advances in Colloid and Interface Science - April 21, 2023 Category: Chemistry Authors: Vuk Uskokovi ć Source Type: research

Exosomes as Immunotheranostic Nanoparticles.
CONCLUSION: Exosomes have numerous functions, and their double-edged features make the scope of their clinical applications, as both a diagnostic and therapeutic tool, immense. PMID: 24863261 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - May 23, 2014 Category: Drugs & Pharmacology Authors: Natasha G, Gundogan B, Tan A, Farhatnia Y, Wu W, Rajadas J, Seifalian AM Tags: Clin Ther Source Type: research

A review on recent trends of antiviral nanoparticles and airborne filters: special insight on COVID-19 virus
AbstractNovel corona virus (COVID-19) pandemic in the last 4  months stimulates the international scientific community to search for vaccine of antiviral agents suitable for in activating the virus inside and outside the human body. More than 4 million people globally are infected by the virus and about 300,000 dead cases until this moment. The ventilation a nd airborne filters are also investigated aiming to develop an efficient antiviral filtration technology. Human secretion of the infected person as nasal or saliva droplets goes as airborne and distributes the virus everywhere around the person. N95 and N98 filters ar...
Source: Air Quality, Atmosphere and Health - June 17, 2021 Category: Environmental Health Source Type: research

Assessment of Exenatide loaded Biotinylated Trimethylated Chitosan/HP-55 Nanoparticles
CONCLUSION: Bio-TMC/HP-55 nanoparticles are feasible as oral drug carriers of exenatide and have the potential to be extended to other drugs that are not readily oral, such as monoclonal antibodies, vaccines, genes, etc., thus, this would be beneficial for pharmaceutical industries. Further research will focus on the biodistribution of Bio-TMC/HP-55 nanoparticles after oral administration.PMID:34126896 | DOI:10.2174/1567201818666210614100603
Source: Current Drug Delivery - June 15, 2021 Category: Drugs & Pharmacology Authors: Hejian Guo Xuehui Yan Hao Tang Xiaoyan Zhang Source Type: research

Potential of < em > Azadirachta indica < /em > as a Capping Agent for Antiviral Nanoparticles against SARS-CoV-2
Biomed Res Int. 2022 Sep 15;2022:5714035. doi: 10.1155/2022/5714035. eCollection 2022.ABSTRACTA rare type of pneumonia later on referred to as COVID-19 was reported in China in December 2019. Investigations revealed that this disease is caused by a coronavirus previously identified as SARS-CoV-2, and since then, it has become a global pandemic with new strains emerging rapidly as a result of genetic mutations. Various therapeutic options are being explored in order to eradicate this pandemic even though approved vaccine candidates are being currently rolled out globally. Most medicinal plant extracts have astonishing prope...
Source: Biomed Res - September 26, 2022 Category: Research Authors: Frank Eric Tatsing Foka Nanabi Manamela Steven Maluta Mufamadi Hazel Tumelo Mufhandu Source Type: research

Hybrid Membrane-Coated Biomimetic Nanoparticles (HM@BNPs): A Multifunctional Nanomaterial for Biomedical Applications
Biomacromolecules. 2021 Jul 6. doi: 10.1021/acs.biomac.1c00440. Online ahead of print.ABSTRACTThe application of nanoparticles in the diagnosis and treatment of diseases has undergone different developmental stages, but phagocytosis and nonspecific distribution have been the main factors restricting the transformation of nanobased drugs into clinical practice. In the past decade, the design of membrane-coated nanoparticles has gained increasing attention. It is hoped that the combination of the cell membrane's natural biological properties and the functional integration of synthetic nanoparticle systems can compensate for ...
Source: Biomacromolecules - July 6, 2021 Category: Biochemistry Authors: Yunan Zhao Aixue Li Liangdi Jiang Yongwei Gu Jiyong Liu Source Type: research

Isolation, characterization and in-vitro antigenicity studies of outer membrane proteins (OMPs) of Salmonella gallinarum coated gold nanoparticles (AuNPs)
Immunobiology. 2021 Aug 24;226(5):152131. doi: 10.1016/j.imbio.2021.152131. Online ahead of print.ABSTRACTThe development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative therapeutic strategies as compared to traditional line of therapeutics. Therefore, the research was conducted to prepare the outer membrane proteins (OMPs) from Salmonella gallinarum and coated on to the surface of synthetic gold nanoparticles (AuNPs). The size of the final product was characterized by Zeta sizer and Zeta potential. The coating of outer membrane proteins onto the g...
Source: Immunobiology - August 30, 2021 Category: Allergy & Immunology Authors: Majid Anwar Faqir Muhammad Bilal Aslam Muhammad Kashif Saleemi Source Type: research

An antigen display system of GEM nanoparticles based on affinity peptide ligands
Int J Biol Macromol. 2021 Oct 23:S0141-8130(21)02293-5. doi: 10.1016/j.ijbiomac.2021.10.135. Online ahead of print.ABSTRACTGram-positive enhancer matrix (GEM) nanoparticles are often used in mucosal immunity, preparation of subunit vaccines or as an immune adjuvant due to its good immunological activities in recent years. Here, we designed and screened out a high affinity peptide ligand PL23, which could specifically target the non-epitope region of Classic Swine Fever Virus (CSFV) E2 protein, by virtual screening technology, enzyme linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR) test. The OD value o...
Source: International Journal of Biological Macromolecules - October 26, 2021 Category: Biochemistry Authors: Man Hu Fangyu Wang Ning Li Guangxu Xing Xuefeng Sun Yunshang Zhang Shuai Cao Ningning Cui Gaiping Zhang Source Type: research