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Vaccination: Meningitis Vaccine
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Total 2900 results found since Jan 2013.
Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model.
CONCLUSIONS: The chitosan and liposome nanoparticles as adjuvant codelivery were successfully synthesized. These nanoparticles have different shapes in particle formation, liposome nanoparticle with their unilamellar shape and chitosan nanoparticles in large shape due to the aggregation of small-size particles. Codelivery of chitosan nanoparticles has more effect on the IgG subclass antibody production than that of liposome nanoparticles in a mouse model.
PMID: 28758135 [PubMed - in process]
Source: Journal of Immunology Research - August 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles
In this study, a dry powder vaccine containing an important antigen of S. pneumoniae, pneumococcal surface protein A (PspA) that has shown cross-reactivity amongst serotypes to be delivered via the pulmonary route has been formulated. The formulation contains the antigen PspA adsorbed onto the surface of polymeric nanoparticles encapsulated in l-leucine microparticles that can be loaded into capsules and delivered via an inhaler. We have successfully synthesized particles of ∼150nm and achieved ∼20μg of PspA adsorption per mg of NPs. In addition, the spray-dried powders displayed a FPF of 74.31±1.32% and MMAD of 1.70...
Source: International Journal of Pharmaceutics - October 21, 2015 Category: Drugs & Pharmacology Source Type: research
Effectiveness of the pneumococcal polysaccharide and conjugated vaccines in elderly and high-risk populations in preventing invasive pneumococcal disease: A systematic search and review of the literature
Conclusion: The results from this review indicate a reduction of IPD in elderly and high-risk populations vaccinated with PPV23 and PCV13. The protective effect may be lower in elderly individuals >80 years and in individuals with comorbidities. However, the literature is sparse and large-scale prospective studies are needed to evaluate the effectiveness of PPV23 and PCV13 vaccination in adults in protecting against IPD.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Sikjaer, M., Wik, M. S., Stensholt, S. S., Hilberg, O., Lokke, A. Tags: 10.01 - Respiratory infections and bronchiectasis Source Type: research
Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models.
Abstract
Vaccine design ushered in the era of nanotechnology, as the vaccine is being developed toward particulate formulation. We have previously shown that the attenuated pneumolysin mutant (ΔA146PLY) was a safe and effective pneumococcal vaccine candidate. Here, to further optimize the formulation, we fused calcium phosphate (CaP) binding domains with ΔA146PLY so that the biocompatible CaP can mineralize with the protein automatically, allowing simple production of nanoparticle antigen during preparation. We fabricated four different nanoparticles, and then we compared the characteristics of different CaP-ΔA...
Source: Biomaterials - November 20, 2017 Category: Materials Science Authors: Wu J, Wu K, Xu W, Yuan T, Wang X, Zhang J, Min Y, Yin Y, Zhang X Tags: Biomaterials Source Type: research
Spontaneous reports of primary ovarian insufficiency after vaccination: A review of the vaccine adverse event reporting system (VAERS)
CONCLUSIONS: POI is rarely reported to VAERS. Most reports contained limited diagnostic information and were submitted after published cases of POI following HPV vaccination. Results of our review do not suggest a safety concern.PMID:36732165 | DOI:10.1016/j.vaccine.2022.12.038
Source: Vaccine - February 2, 2023 Category: Allergy & Immunology Authors: A Patricia Wodi Paige Marquez Adamma Mba-Jonas Faith Barash Kosal Nguon Pedro L Moro Source Type: research
The Effectiveness of Disaster Risk Communication: A Systematic Review of Intervention Studies
The objectives of the interventions were to improve the health knowledge and behaviour in relation to disasters, and to decrease the incidence of negative health events. The studies were chosen on that basis, and several studies reported additional outcomes that were outside the scope of this review. The knowledge, behaviour and incidence outcomes are described in detail in Appendix 3 (characteristics and results of included studies).
Results of Individual Studies
1 Effect of Risk Communication Interventions to Promote Disaster Mitigation and Preparedness
1.1 Communication to Promote Mitigation and Preparedness for Infec...
Source: PLOS Currents Disasters - August 22, 2014 Category: Global & Universal Authors: dtbradley Source Type: research
Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome
In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating th...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research
The Role of Media and the Internet on Vaccine Adverse Event Reporting: A Case Study of Human Papillomavirus Vaccination
Conclusions: We demonstrate that media coverage and Internet search activity, in particular, may promote increased adverse event reporting. Public health officials who have long recognized the importance of proactive engagement with news media must now consider strategies for meaningful participation in Internet discussions.
Source: Journal of Adolescent Health - November 18, 2013 Category: Child Development Authors: Jan M. Eberth, Kimberly N. Kline, David A. Moskowitz, Jane R. Montealegre, Michael E. Scheurer Tags: Original Articles Source Type: research
Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease
CONCLUSIONS: The evidence examined was determined to be of low certainty and suggests that prophylactic penicillin significantly reduces risk of pneumococcal infection in children with homozygous SCD, and is associated with minimal adverse reactions. Further research may help to determine the ideal age to safely withdraw penicillin.PMID:33724440 | DOI:10.1002/14651858.CD003427.pub5
Source: Cochrane Database of Systematic Reviews - March 16, 2021 Category: General Medicine Authors: Angela E Rankine-Mullings Shirley Owusu-Ofori Source Type: research
Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.
CONCLUSIONS: Prophylactic penicillin significantly reduces risk of pneumococcal infection in children with homozygous sickle cell disease, and is associated with minimal adverse reactions. Further research may help to determine the ideal age to safely withdraw penicillin.
PMID: 25375222 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 6, 2014 Category: Journals (General) Authors: Hirst C, Owusu-Ofori S Tags: Cochrane Database Syst Rev Source Type: research
Mucosal immunization with PsaA protein, using chitosan as a delivery system, increases protection against acute otitis media and invasive infection by Streptococcus pneumoniae
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - January 6, 2015 Category: Allergy & Immunology Authors: Jiang‐hong Xu, Wen‐jia Dai, Bing Chen, Xiao‐yong Fan, Zheng‐min Wang Tags: Regular Article Source Type: research
Behind the Headlines' Top Five of Top Fives 2015
In this study, researchers wanted to see why this is and if there could be any human applications.Researchers collected white blood cells from African and Asian elephants. They found that elephants have at least 20 copies of a gene called TP53. TP53 is known to encourage cell "suicide" when DNA is damaged, stopping any potential cancer in its tracks. In contrast, humans are thought to have only a single copy of the TP53 gene.Of course the big question – the elephant in the room, if you will – is how we can boost TP53 activity in humans to stimulate a similar protective effect. The simple answer is: we don't k...
Source: NHS News Feed - December 24, 2015 Category: Consumer Health News Tags: QA articles Medical practice Special reports Source Type: news
Behind the Headlines Top Five of Top Fives 2015
In this study, researchers wanted to see why this is and if there could be any human applications.
Researchers collected white blood cells from African and Asian elephants. They found elephants have at least 20 copies of a gene called TP53. TP53 is known to encourage cell "suicide" when DNA is damaged, stopping any potential cancer in its tracks. In contrast, humans are thought to have only a single copy of the TP53 gene.
Of course the big question – the elephant in the room, if you will – is how we can boost TP53 activity in humans to stimulate a similar protective effect. The simple answer is: we don't know...
Source: NHS News Feed - December 24, 2015 Category: Consumer Health News Tags: QA articles Medical practice Special reports Source Type: news
Disparities in PCV impact between different ethnic populations cohabiting in the same region: A systematic review of the literature.
CONCLUSION: While differences in IPD and pneumonia rates between resource-poor and resource-rich populations were decreased following PCV introduction, disparity is still apparent and is not fully eliminated in any of the studies. Younger (<2years) populations in resource-poor populations seem to benefit the most from PCV introduction.
PMID: 27443591 [PubMed - as supplied by publisher]
Source: Vaccine - July 17, 2016 Category: Allergy & Immunology Authors: Segal N, Greenberg D, Dagan R, Ben-Shimol S Tags: Vaccine Source Type: research
