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Vaccination: Cervical Cancer Vaccine

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Total 2149 results found since Jan 2013.

Engineering aluminum hydroxyphosphate nanoparticles with well-controlled surface property to enhance humoral immune responses as vaccine adjuvants
This study shows that engineering AAHPs with well-controlled physicochemical properties enable the establishment of a structure-activity relationship that is critical to instruct the design of suitable engineered nanomaterial-based adjuvants within vaccine formulations for the benefits of human health.PMID:34147722 | DOI:10.1016/j.biomaterials.2021.120960
Source: Biomaterials - June 20, 2021 Category: Materials Science Authors: Zhihui Liang Yun Yang Ge Yu Haoru Zhu Xinyu Xia Chen Chen Duo Fu Min Li Gang Cheng Changying Xue Li Shi Hao Zeng Bingbing Sun Source Type: research

Protein vaccination with HPV16 E7/Pep‐1 nanoparticles elicits a protective T‐helper cell‐mediated immune response
In this study, we used a short amphipathic peptide carrier, Pep‐1, for delivery of the full‐length HPV16 E7 protein into mammalian cells and evaluated immune responses and protective effects of different formulations in C57BL/6 tumor mice model. Our results showed that the complexes of E7/Pep‐1 protein form stable nanoparticles through noncovalent binding with an average size of 120 to 250 nm. The efficient delivery of E7 protein by Pep‐1 at molar ratio of 1:20 was detected in HEK‐293T cell line for 1 h and 3 h post‐transfection. Immunization with E7/Pep‐1 nanoparticles at a ratio of 1:20 induced a higher Th1...
Source: IUBMB Life - March 31, 2016 Category: Research Authors: Golnaz Mardani, Azam Bolhassani, Elnaz Agi, Sepideh Shahbazi, Seyed Mehdi Sadat Tags: Research Communication Source Type: research

Broad Neutralization Responses Against Oncogenic Human Papillomaviruses Induced by a Minor Capsid L2 Polytope Genetically Incorporated Into Bacterial Ferritin Nanoparticles
Cervical cancer remains a global health burden despite the introduction of highly effective vaccines for the prophylaxis of causative human papillomavirus infection (HPV). Current efforts to eradicate cervical cancer focus on the development of broadly protective, cost-effective approaches. HPV minor capsid protein L2 is being recognized as a promising alternative to the major capsid protein L1 because of its ability to induce responses against a wider range of different HPV types. However, a major limitation of L2 as a source of cross-neutralizing epitopes is its lower immunogenicity compared to L1 when assembled into VLP...
Source: Frontiers in Immunology - December 4, 2020 Category: Allergy & Immunology Source Type: research

The Role of Pejorative Search Terms and Professional Antivaccine Advocates on Search Engine Results for Human Papillomavirus Vaccine
Fu et al. [1] highlighted important issues relating to the impact of page rankings and search terms on the quality of content that consumers access when seeking information about the human papillomavirus (HPV) vaccine. Of particular importance was recognition that previous articles only used neutral search terms. The authors, thus, utilized a methodology that incorporated non-neutral terms.
Source: Journal of Adolescent Health - May 19, 2016 Category: Child Development Authors: Tracey McDermott, David Hawkes, Joanne Benhamu Tags: Letter to the editor Source Type: research

Heterologous Prime-Boost Vaccination Using Adenovirus and Albumin Nanoparticles as Carriers for Human Papillomavirus 16 E7 Epitope
CONCLUSION: In conclusion, the heterologous nanocomplexes might serve as an effective vaccine strategy against HPV-induced cervical cancer.PMID:36154591 | DOI:10.2174/1389201023666220922122531
Source: Current Pharmaceutical Biotechnology - September 26, 2022 Category: Biotechnology Authors: Momeneh Ghanaat Hami Kaboosi Babak Negahdari Esmail Fattahi Ziba Veisi Malekshahi Source Type: research

Search Engine Ranking, Quality, and Content of Web Pages That Are Critical Versus Noncritical of Human Papillomavirus Vaccine
Online information can influence attitudes toward vaccination. The aim of the present study was to provide a systematic evaluation of the search engine ranking, quality, and content of Web pages that are critical versus noncritical of human papillomavirus (HPV) vaccination.
Source: Journal of Adolescent Health - November 7, 2015 Category: Child Development Authors: Linda Y. Fu, Kathleen Zook, Zachary Spoehr-Labutta, Pamela Hu, Jill G. Joseph Tags: Original article Source Type: research

MPG-based nanoparticle: An efficient delivery system for enhancing the potency of DNA vaccine expressing HPV16E7.
In this study, a peptide-based gene delivery system, MPG, which forms stable non-covalent nanoparticles with nucleic acids, was used for in vitro and in vivo delivery of HPV16 E7 DNA as a model antigen. The results demonstrated that at Nitrogen/Phosphate (N/P) ratio over 10:1, this peptide can effectively condense plasmid DNA into stable nanoparticles with an average size of 180-210nm and a positive surface charge. The transfection efficiency of MPG-based nanoparticles was shown to be comparable with Polyethyleneimine (PEI). The efficient protein expression detected by western blotting and flow cytometry supports the poten...
Source: Vaccine - May 19, 2015 Category: Allergy & Immunology Authors: Saleh T, Bolhassani A, Shojaosadati SA, Aghasadeghi MR Tags: Vaccine Source Type: research

Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform.
Abstract While nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. One such particle is the hepatitis B virus surface antigen (sAg) that exists as nanoparticles. Here we show, using biochemical analysis coupled with electron microscopy, that sAg nanoparticle disassembly requires both reducing agent to disrupt intermolecular disulfide bonds, and detergent to disrupt hydrophobic interact...
Source: Virology - January 2, 2017 Category: Virology Authors: Gallagher JR, Torian U, McCraw DM, Harris AK Tags: Virology Source Type: research

Spontaneous reports of primary ovarian insufficiency after vaccination: A review of the vaccine adverse event reporting system (VAERS)
CONCLUSIONS: POI is rarely reported to VAERS. Most reports contained limited diagnostic information and were submitted after published cases of POI following HPV vaccination. Results of our review do not suggest a safety concern.PMID:36732165 | DOI:10.1016/j.vaccine.2022.12.038
Source: Vaccine - February 2, 2023 Category: Allergy & Immunology Authors: A Patricia Wodi Paige Marquez Adamma Mba-Jonas Faith Barash Kosal Nguon Pedro L Moro Source Type: research

Supercharged green fluorescent protein delivers HPV16E7 DNA and protein into mammalian cells in vitro and in vivo.
In this study, we used a supercharged green fluorescent protein (+36 GFP) for delivery of the full-length HPV16 E7 DNA and protein into mammalian cells and evaluated immune responses, and protective/therapeutic effects of different formulations in C57BL/6 tumor mice model. Our results showed that the complexes of E7 DNA/+36 GFP and also E7 protein/+36 GFP form stable nanoparticles through non-covalent binding with an average size of ∼ 200-300 nm. The efficient delivery of E7 DNA or protein by +36 GFP was detected in HEK-293T cell line for 4 h and 24 h post-transfection. Mice immunization with E7 protein/+36 GFP...
Source: Immunology Letters - December 19, 2017 Category: Allergy & Immunology Authors: Motevalli F, Bolhassani A, Hesami S, Shahbazi S Tags: Immunol Lett Source Type: research

HPV Vaccine Searches on Pinterest: Before and After Pinterest's Actions to Moderate Content.
Conclusions. Pinterest's efforts to moderate vaccination discussions were largely successful. However, the ban also appeared to limit HPV vaccination search results overall, which may contribute to confusion or an information vacuum. PMID: 33001720 [PubMed - in process]
Source: American Journal of Public Health - September 30, 2020 Category: International Medicine & Public Health Authors: Guidry JPD, Vraga EK, Laestadius LI, Miller CA, Occa A, Nan X, Ming HM, Qin Y, Fuemmeler BF, Carlyle KE Tags: Am J Public Health Source Type: research

The Role of Media and the Internet on Vaccine Adverse Event Reporting: A Case Study of Human Papillomavirus Vaccination
Conclusions: We demonstrate that media coverage and Internet search activity, in particular, may promote increased adverse event reporting. Public health officials who have long recognized the importance of proactive engagement with news media must now consider strategies for meaningful participation in Internet discussions.
Source: Journal of Adolescent Health - November 18, 2013 Category: Child Development Authors: Jan M. Eberth, Kimberly N. Kline, David A. Moskowitz, Jane R. Montealegre, Michael E. Scheurer Tags: Original Articles Source Type: research

Bad news: The influence of news coverage and Google searches on Gardasil adverse event reporting.
CONCLUSION: The results suggest that some of the adverse events reported were not related to the vaccination itself, but to news coverage and internet search volumes, which may have contributed to public concerns about potentially unpleasant or harmful outcomes. These findings have implications for the importance of psychological and social factors in adverse event reporting, and the role of the news media in disseminating health information. PMID: 29128382 [PubMed - as supplied by publisher]
Source: Vaccine - November 8, 2017 Category: Allergy & Immunology Authors: Faasse K, Porsius JT, Faasse J, Martin LR Tags: Vaccine Source Type: research