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Total 136064 results found since Jan 2013.
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
CONCLUSIONS: Collectively, our study highlights the utility of the dual-reporter system for real-time monitoring and quantitative analysis of protein secretion through conventional ER-Golgi and unconventional exosome pathways. Moreover, our findings unveil distinct features of exosome-mediated protein secretion, shedding light on its differential capacity, dynamics, and regulatory mechanisms compared to ER-Golgi-mediated proteins in human cells.PMID:37726652 | DOI:10.1186/s12575-023-00219-w
Source: Biological Procedures Online - September 19, 2023 Category: Molecular Biology Authors: Christopher Olson Pengyang Zhang Joy Ku Renceh Flojo Darin Boyes Biao Lu Source Type: research
Corrigendum
J Cell Mol Med. 2023 Sep 18. doi: 10.1111/jcmm.17830. Online ahead of print.NO ABSTRACTPMID:37723981 | DOI:10.1111/jcmm.17830
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Source Type: research
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans
CONCLUSION: Our results suggested that in oral epithelial cells, the NLRP3 inflammasome might be one of the target pathways by which CSE attenuates innate immunity and leads to oral disorders.PMID:37723958 | DOI:10.2174/1566524023666230612143038
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Fan Huang Ruiqi Xie Ruowei Li Liu Liu Maomao Zhao Qiong Wang Weida Liu Pei Ye Wenmei Wang Xiang Wang Source Type: research
Emetine dihydrochloride alleviated radiation-induced lung injury through inhibiting EMT
In this study, we demonstrated that emetine dihydrochloride (EDD) alleviated RILI through inhibiting EMT. We found that EDD significantly attenuated EMT-related markers, reduced Smad3 phosphorylation expression after radiation. Then, for the first time, we observed EDD alleviated lung hyperaemia and reduced collagen deposit induced by irradiation, providing protection against RILI. Finally, it was found that EDD inhibited radiation-induced EMT in lung tissues. Our study suggested that EDD alleviated RILI through inhibiting EMT by blocking Smad3 signalling pathways. In summary, our results indicated that EDD is a novel pote...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Xin Wang Mo Li Jizhong Yin Jiayan Fang Yimeng Ying Tianxia Ye Fangxiao Zhang Shumei Ma Hongran Qin Xiaodong Liu Source Type: research
Mutations in CFAP47, a previously reported MMAF causative gene, also contribute to the respiratory defects in patients with PCD
CONCLUSIONS: We describe two hemizygous missense variants of X-linked CFAP47 in two unrelated PCD individuals and prove CFAP47 variants are related to a reduced number of epithelial ciliary cells. Therefore, we suggest that CFAP47 should be known as a novel pathogenic gene of human PCD.PMID:37723893 | DOI:10.1002/mgg3.2278
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Haijun Ge Wangji Zhou Miao He Haixia Zheng Xinyue Zhao Ting Zhang Ying Zhang Chi Shao Chongsheng Cheng Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang Source Type: research
Antimalarial drug discovery against malaria parasites through haplopine modification: An advanced computational approach
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17940. Online ahead of print.ABSTRACTThe widespread emergence of antimalarial drug resistance has created a major threat to public health. Malaria is a life-threatening infectious disease caused by Plasmodium spp., which includes Apicoplast DNA polymerase and Plasmodium falciparum cysteine protease falcipain-2. These components play a critical role in their life cycle and metabolic pathway, and are involved in the breakdown of erythrocyte hemoglobin in the host, making them promising targets for anti-malarial drug design. Our current study has been designed to explore the pote...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Shopnil Akash Guendouzi Abdelkrim Imren Bayil Md Eram Hosen Nobendu Mukerjee Abdullah F Shater Fayez M Saleh Ghadeer M Albadrani Muath Q Al-Ghadi Mohamed M Abdel-Daim Tu ğba Taşkin Tok Source Type: research
An effective disease diagnostic model related to pyroptosis in ischemic cardiomyopathy
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17957. Online ahead of print.ABSTRACTPyroptosis is involved in ischemic cardiomyopathy (ICM). The study aimed to investigate the pyroptosis-related genes and clarify their diagnostic value in ICM. The bioinformatics method identified the differential pyroptosis genes between the normal control and ICM samples from online datasets. Then, protein-protein interaction (PPI) and function analysis were carried out to explore the function of these genes. Following, subtype analysis was performed using ConsensusClusterPlus, functions, immune score, stromal score, immune cell proportio...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Zhankui Jin Fuqiang Liu Guoan Zhang Jingtao Zhang Xiangrong Zhao Xueping Huo Xiaoyan Huang Cuixiang Xu Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
Amphipathic Helical Peptide L37-pA Protects Against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor
Am J Respir Cell Mol Biol. 2023 Sep 19. doi: 10.1165/rcmb.2023-0127OC. Online ahead of print.ABSTRACTGeneration of bioactive truncated oxidized phospholipids (Tr-OxPLs) from oxidation of cell membrane or circulating lipoproteins is a common feature of various pathological states. Scavenger receptor CD36 is involved in lipid transport and acts as a ligand for Tr-OxPLs. Interestingly, both Tr-OxPLs and CD36 are involved in endothelial dysfunction-derived acute lung injury but precise mechanistic connections remain unexplored. In the present study, we investigated the role of CD36 in mediating pulmonary endothelial cell (EC) ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 19, 2023 Category: Molecular Biology Authors: Pratap Karki Yue Li Chen-Ou Zhang Yunbo Ke Kamoltip Promnares Anna A Birukova Thomas L Eggerman Alexander V Bocharov Konstantin G Birukov Source Type: research
corrigendum
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17829. Online ahead of print.NO ABSTRACTPMID:37724039 | DOI:10.1111/jcmm.17829
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Source Type: research
Corrigendum
J Cell Mol Med. 2023 Sep 18. doi: 10.1111/jcmm.17830. Online ahead of print.NO ABSTRACTPMID:37723981 | DOI:10.1111/jcmm.17830
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Source Type: research
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer
Conclusion: Nuclear imaging plays an important role in the diagnosis, staging, and management of thyroid cancer. The use of radioiodine imaging, thyroglobulin imaging, FDG imaging, and somatostatin receptor imaging are all valuable tools in the evaluation of thyroid cancer. With further research and development, nuclear imaging techniques have the potential to improve the diagnosis and management of thyroid cancer and other endocrine malignancies.PMID:37724677 | DOI:10.2174/1566524023666230915103723
Source: Current Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Namit Kant Singh Neemu Hage Balaji Ramamourthy Sushmitha Nagaraju Krishna Medha Kappagantu Source Type: research
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans
CONCLUSION: Our results suggested that in oral epithelial cells, the NLRP3 inflammasome might be one of the target pathways by which CSE attenuates innate immunity and leads to oral disorders.PMID:37723958 | DOI:10.2174/1566524023666230612143038
Source: Current Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Fan Huang Ruiqi Xie Ruowei Li Liu Liu Maomao Zhao Qiong Wang Weida Liu Pei Ye Wenmei Wang Xiang Wang Source Type: research
Pyramiding resistance genes for bacterial leaf blight (Xanthomonas oryzae pv. Oryzae) into the popular rice variety, Pratikshya through marker assisted backcrossing
CONCLUSION: The three-gene pyramided lines showed a high level of resistance to BLB infection and are anticipated to offer a significant yield advantage over the recipient parent Pratikshya. The pyramided lines can further be used for multi-location trial, so as to be released as a variety or can be used as a potential donor for BLB resistance genes.PMID:37725285 | DOI:10.1007/s11033-023-08805-7
Source: Molecular Biology Reports - September 19, 2023 Category: Molecular Biology Authors: Madhuri Pradhan Debendranath Bastia Kailash Chandra Samal Manasi Dash Jyoti Prakash Sahoo Source Type: research
In vitro naive CD4 < sup > + < /sup > T cell differentiation upon treatment with miR-29b-loaded exosomes from mesenchymal stem cells
CONCLUSIONS: In conclusion, AMSC-Exo-based delivery of miR-29b can be considered as a new fascinating avenue for T cell differentiation inhibition and the future treatment of several inflammatory disorders.PMID:37725284 | DOI:10.1007/s11033-023-08767-w
Source: Molecular Biology Reports - September 19, 2023 Category: Molecular Biology Authors: Zohreh Bolandi Seyed Mahmoud Hashemi Mozhgan Abasi Maryam Musavi Shahin Aghamiri Nastaran Miyanmahaleh Hossein Ghanbarian Source Type: research
