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A review: FDA-approved fluorine-containing small molecules from 2015 to 2022
Eur J Med Chem. 2023 Aug 24;260:115758. doi: 10.1016/j.ejmech.2023.115758. Online ahead of print.ABSTRACTFluorine-containing small molecules have occupied a special position in drug discovery research. The successful clinical use of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s led to an ever-increasing number of approved fluorinated compounds over the last 50 years. They have shown various biological properties such as antitumor, antimicrobial, and anti-inflammatory activities. Fluoro-pharmaceuticals have been considered a strong and practical tool in the rational drug design approach due to t...
Source: European Journal of Medicinal Chemistry - September 1, 2023 Category: Chemistry Authors: Negar Sheikhi Maryam Bahraminejad Mina Saeedi Seyedeh Sara Mirfazli Source Type: research
Tofacitinib versus oral prednisolone for induction of remission in moderately active ulcerative colitis (ORCHID): A prospective, open-label, randomized, pilot study
CONCLUSION: In patients with moderately active ulcerative colitis, there was no difference in the efficacy and safety of tofacitinib and oral prednisolone for induction of remission at 8 weeks.PMID:37656880 | DOI:10.1093/ecco-jcc/jjad153
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Arshdeep Singh Vandana Midha Kirandeep Kaur Ramit Mahajan Dharmatma Singh Ramandeep Kaur Aditya Kohli Avantika Chawla Kriti Sood Namita Bansal Ajit Sood Source Type: research
Bullous cellulitis as an extraordinary manifestation of a Vibrio cholerae O1 Ogawa infection
We describe a case of a 63-year-old Chinese woman with multiple medical comorbidities on corticosteroid therapy who developed fever and a painful swelling on her left leg after being pricked by a branch while gardening. There was no abdominal pain, vomiting or diarrhea. A diagnosis of bullous cellulitis was made clinically, and blood was sent for bacteriological culture. A beta-hemolytic commashaped gram-negative bacillus was isolated from the blood. It was also oxidase-positive and produced an acid/alkaline (A/K) reaction on triple sugar iron agar. It was identified biochemically as Vibrio cholerae. After additional testi...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: S F Ummu C H Ding A A Wahab M N Tzar Source Type: research
Identification and structural characterization of major stress degradation products of halcinonide by liquid chromatography-high-resolution mass spectrometry
Biomed Chromatogr. 2023 Aug 31:e5730. doi: 10.1002/bmc.5730. Online ahead of print.ABSTRACTHalcinonide is a topical corticosteroid approved by the US Food and Drug Administration (FDA), known for its anti-inflammatory and antipruritic properties. The therapeutic benefits of halcinonide have rendered it an effective treatment regimen for various dermatological conditions such as psoriasis, dermatitis, and eczema. However, stability of the drug substance is a prerequisite in determining the therapeutic efficacy and plays a crucial role during formulation development and long-term storage. As corticosteroids are highly suscep...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Shivraj Giri Devendra Badgujar Sree Teja Paritala Nitish Sharma Source Type: research
Bullous cellulitis as an extraordinary manifestation of a Vibrio cholerae O1 Ogawa infection
We describe a case of a 63-year-old Chinese woman with multiple medical comorbidities on corticosteroid therapy who developed fever and a painful swelling on her left leg after being pricked by a branch while gardening. There was no abdominal pain, vomiting or diarrhea. A diagnosis of bullous cellulitis was made clinically, and blood was sent for bacteriological culture. A beta-hemolytic commashaped gram-negative bacillus was isolated from the blood. It was also oxidase-positive and produced an acid/alkaline (A/K) reaction on triple sugar iron agar. It was identified biochemically as Vibrio cholerae. After additional testi...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: S F Ummu C H Ding A A Wahab M N Tzar Source Type: research
Identification and structural characterization of major stress degradation products of halcinonide by liquid chromatography-high-resolution mass spectrometry
Biomed Chromatogr. 2023 Aug 31:e5730. doi: 10.1002/bmc.5730. Online ahead of print.ABSTRACTHalcinonide is a topical corticosteroid approved by the US Food and Drug Administration (FDA), known for its anti-inflammatory and antipruritic properties. The therapeutic benefits of halcinonide have rendered it an effective treatment regimen for various dermatological conditions such as psoriasis, dermatitis, and eczema. However, stability of the drug substance is a prerequisite in determining the therapeutic efficacy and plays a crucial role during formulation development and long-term storage. As corticosteroids are highly suscep...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Shivraj Giri Devendra Badgujar Sree Teja Paritala Nitish Sharma Source Type: research
Bullous cellulitis as an extraordinary manifestation of a Vibrio cholerae O1 Ogawa infection
We describe a case of a 63-year-old Chinese woman with multiple medical comorbidities on corticosteroid therapy who developed fever and a painful swelling on her left leg after being pricked by a branch while gardening. There was no abdominal pain, vomiting or diarrhea. A diagnosis of bullous cellulitis was made clinically, and blood was sent for bacteriological culture. A beta-hemolytic commashaped gram-negative bacillus was isolated from the blood. It was also oxidase-positive and produced an acid/alkaline (A/K) reaction on triple sugar iron agar. It was identified biochemically as Vibrio cholerae. After additional testi...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: S F Ummu C H Ding A A Wahab M N Tzar Source Type: research
Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis
CONCLUSIONS: While early treatment with moderate-dose dexamethasone or late treatment with high-dose dexamethasone may lead to the best effects for survival without BPD, the certainty of the evidence is low. There is insufficient evidence to guide this therapy with regard to plausible adverse long-term outcomes. Further RCTs with direct comparisons between systemic corticosteroid treatments are needed to determine the optimal treatment approach, and these studies should be adequately powered to evaluate survival without major neurosensory disability.PMID:37650547 | DOI:10.1002/14651858.CD013730.pub2
Source: Cochrane Database of Systematic Reviews - August 31, 2023 Category: General Medicine Authors: Susanne Hay Colleen Ovelman John Af Zupancic Lex W Doyle Wes Onland Menelaos Konstantinidis Prakeshkumar S Shah Roger Soll Source Type: research
Identification and structural characterization of major stress degradation products of halcinonide by liquid chromatography-high-resolution mass spectrometry
Biomed Chromatogr. 2023 Aug 31:e5730. doi: 10.1002/bmc.5730. Online ahead of print.ABSTRACTHalcinonide is a topical corticosteroid approved by the US Food and Drug Administration (FDA), known for its anti-inflammatory and antipruritic properties. The therapeutic benefits of halcinonide have rendered it an effective treatment regimen for various dermatological conditions such as psoriasis, dermatitis, and eczema. However, stability of the drug substance is a prerequisite in determining the therapeutic efficacy and plays a crucial role during formulation development and long-term storage. As corticosteroids are highly suscep...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Shivraj Giri Devendra Badgujar Sree Teja Paritala Nitish Sharma Source Type: research
Bullous cellulitis as an extraordinary manifestation of a Vibrio cholerae O1 Ogawa infection
We describe a case of a 63-year-old Chinese woman with multiple medical comorbidities on corticosteroid therapy who developed fever and a painful swelling on her left leg after being pricked by a branch while gardening. There was no abdominal pain, vomiting or diarrhea. A diagnosis of bullous cellulitis was made clinically, and blood was sent for bacteriological culture. A beta-hemolytic commashaped gram-negative bacillus was isolated from the blood. It was also oxidase-positive and produced an acid/alkaline (A/K) reaction on triple sugar iron agar. It was identified biochemically as Vibrio cholerae. After additional testi...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: S F Ummu C H Ding A A Wahab M N Tzar Source Type: research
